Corticosteroid therapy for AIDS patients with Mycobacterium avium-intracellulare infection

Steven, Neil; Pithie, AlanD.; Wood, Matthew P.; Innes, J A

doi:10.1097/00002030-199401000-00027

Cited by 4 publications

(2 citation statements)

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“…Anti-inflammatory actions, including inhibition of transcription of certain cytokines presumably released during MAC infection, may explain the favorable results we observed (16). This hypothesis is consistent with the beneficial results observed anecdotally in other AIDS patients with disseminated MAC who were treated adjunctively with either prednisolone (16) or thalidomide (2).…”

Section: Discussionsupporting

confidence: 89%

Low-dose dexamethasone as adjunctive therapy for disseminated Mycobacterium avium complex infections in AIDS patients

Wormser

Horowitz

Dworkin

1994

Antimicrob Agents Chemother

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Five human immunodeficiency virus-infected patients with disseminated Mycobacterium avium complex infection had progressive weight loss and persistent fever despite multidrug antimycobacterial therapy. These patients were given daily low-dose oral dexamethasone (typically 2 mg/day) as adjunctive therapy. All had substantial and sustained weight gain (12 to 50%o of pre-steroid treatment body weight [P < 0.03]), reduction in fever, and an improved sense of well-being. The serum albumin level increased during dexamethasone therapy (from 3.06 ± 0.59 g/dl [mean + standard deviation] to 3.9 ± 0.22 g/dl [P < 0.01]), while the serum alkaline phosphatase level fell (from 368 ± 247 U/liter to 128 + 43.6 U/liter [P < 0.04]). Further studies of the potential role for corticosteroids in the management of disseminated M. avium complex infections in human immunodeficiency virus-infected patients are warranted.

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Section: Discussionsupporting

confidence: 89%

Low-dose dexamethasone as adjunctive therapy for disseminated Mycobacterium avium complex infections in AIDS patients

Wormser

Horowitz

Dworkin

1994

Antimicrob Agents Chemother

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“…Some authors have reported the usefulness of adjuvant therapy with corticosteroids for the control of untreatable fever in some patients with disseminated MAC infection (120). In our experience, nonsteroidal anti-inflammatory drugs have been useful both for control of fever and diagnostic orientation in patients with tumoral fever.…”

Section: T H E Undiagnosed Hiv-fuomentioning

confidence: 79%

Fever of Unknown Origin in the HIV-infected Patient: New Scenario for an Old Problem

Mayo¹,

Collazos²,

Martínez³

1997

Scandinavian Journal of Infectious Diseases

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Many conditions may present as fever of unknown origin in the HIV-infected patient, and their relative frequency is influenced by multiple factors. The history and physical examination may provide some useful clues for the diagnosis. Haematological, biochemical, and conventional radiological tests are rarely diagnostic; even serological and/or microbiological tests have some limitations in these patients. The geographical setting and the local prevalence of diseases are of the utmost importance. Infections that have a world-wide distribution, such as tuberculosis, should be intensively searched for, particularly in areas of high prevalence. The measurement of the CD4+ cell count is essential, as there is a strong association between this count and certain opportunistic diseases that may manifest as fever of unknown origin. Imaging procedures, such as CT and radionuclide scans, are useful for the location of inflammatory and neoplastic lesions. Liver and bone marrow biopsies are helpful in certain subsets of patients and the efficacy of empirical treatments has been clearly documented in certain infections. Some HIV-infected patients with fever of unknown origin remain undiagnosed after a thorough investigation; these individuals should be managed conservatively. Finally, symptomatic treatment is the best option for terminally ill patients in whom benefit from a detailed investigation of the cause of fever is not expected.

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Episodios oportunistas en pacientes infectados por el virus de la inmunodeficiencia humana durante los primeros 6 meses de la terapia antirretroviral de gran actividad

González-Castillo¹,

Blanco²,

Soriano³

et al. 2001

Medicina Clínica

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Corticosteroid therapy for AIDS patients with Mycobacterium avium-intracellulare infection

Cited by 4 publications

References 0 publications

Low-dose dexamethasone as adjunctive therapy for disseminated Mycobacterium avium complex infections in AIDS patients

Low-dose dexamethasone as adjunctive therapy for disseminated Mycobacterium avium complex infections in AIDS patients

Fever of Unknown Origin in the HIV-infected Patient: New Scenario for an Old Problem

Episodios oportunistas en pacientes infectados por el virus de la inmunodeficiencia humana durante los primeros 6 meses de la terapia antirretroviral de gran actividad

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