Corticosteroid therapy of alcoholic hepatitis

Accuracy of MELD Scores in Predicting Mortality in Decompensated Cirrhosis from Variceal Bleeding, Hepatorenal Syndrome, Alcoholic Hepatitis, or Acute Liver Failure As Well As Mortality After Non-transplant Surgery or TIPS

“…The most common age of presentation is age 40-50, with most patients presenting before age 60 [79]. The Discriminant Function (DF) was traditionally used to predict mortality in patients with alcoholic hepatitis [80], but its value is somewhat limited because it relies primarily upon prothrombin time, which varies somewhat among different medical laboratories [81]. Recent reports suggest that MELD score can predict mortality among patients hospitalized for alcoholic hepatitis ( (Table 6).…”

Prevalence of Septic Events, Type 1 Hepatorenal Syndrome, and Mortality in Severe Alcoholic Hepatitis and Utility of Discriminant Function and MELD Score in Predicting These Adverse Events

“…Although studies have addressed the prevalence and outcome of SE and type 1 HRS in patients with cirrhosis, there are no similar studies in those with advanced AH. Furthermore, although DF has been shown to predict mortality in AH [6][7][8][9][10][11], the utility of the MELD score has not been extensively studied in this regard. The aims of this study were therefore to assess the (a) prevalence of SE, type 1 HRS, and short-term mortality in patients with severe AH compared to those with advanced cirrhosis in absence of AH, and (b) predictors of these adverse events in patients with AH with special reference to the DF and the MELD score…”

“…Its clinical severity is assessed by discriminant function (DF) and those with a DF of ≥32 at presentation have a 50% in-hospital mortality rate [6][7][8][9][10][11]. Drug therapy of AH remains controversial, with some advocating steroids, and others, tumor necrosis factor (TNF) inhibitors like pentoxifylline.…”

Serum Levels of Keratin-18 Fragments [Tissue Polypeptide-Specific Antigen (TPS)] Are Correlated with Hepatocyte Apoptosis in Alcoholic Hepatitis

“…AST aspartate aminotransferase, ALT alanine aminotransferase, GGT glutamyltransferase a Spearman rank correlation. All 53 cases were included in analyses b Maddrey's discriminant function = 4.6 9 prolongation of prothrombin time (in seconds) + serum bilirubin (in mg/dl) [20] 0-5 6-10 11-20 >20…”

“…Median and (interquartile range) serum levels in alcoholics were: AST 79 IU/l (39-108 IU/l), ALT 42 IU/l (32-76 IU/l), GGT 242 IU/l (118-806 IU/l), and bilirubin 1.2 mg/dl (0.6-2.4 mg/dl). Maddrey's discriminant function (4.6 9 prolongation of prothrombin time [in seconds] + serum bilirubin [in mg/dl]) was used to assess the severity of alcoholic liver disease [20]. Only two patients showed discriminant function values [32, which are indicative of severe alcoholic hepatitis [20].…”