Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes

Zhou, Chun-Lei; Yu, Xiao-Jing; Chen, La-Mei; Jiang, Hong; Li, Chunyang

doi:10.1016/j.regpep.2009.10.001

Cited by 18 publications

(8 citation statements)

References 58 publications

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“…) (Zhou et al . ), and this was consistent with our data which showed that P38 inhibitor significantly enhanced VEGF production in LA and RA fibroblasts, whereas ERK inhibitor significantly increased the VEGF production ability in RA fibroblasts only. These results suggested that the MAPK signalling pathway may be a negative upstream regulator of VEGF production in RA and LA (especially RA) fibroblasts.…”

Section: Discussionsupporting

confidence: 93%

A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress‐induced mitogen‐activated protein kinase signalling in rats

et al. 2017

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Section: Discussionsupporting

confidence: 93%

A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress‐induced mitogen‐activated protein kinase signalling in rats

et al. 2017

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“…It also stimulates mast cells and plays a role as a pro-inflammatory agent [ 60 , 66 ]. In contrast to its role of proinflammatory effects, CRH also shows its anti-inflammatory characteristics by modulating vascular permeability, angiogenesis, and cytokine production [ 65 , 67 , 68 ]. Through CRH-R1 activation, keratinocytes reduce the expression of vascular endothelial growth factor [ 68 ].…”

Section: The Peripheral Hpa Axismentioning

confidence: 99%

Association between Stress and the HPA Axis in the Atopic Dermatitis

Lin

Zhong

Santiago

2017

IJMS

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The hypothalamic–pituitary–adrenal (HPA) axis is one of the body’s neuroendocrine networks that responds to psychological stress (PS). In the skin, there exists a peripheral HPA axis similar to the central axis. Glucocorticoids (GCs) are key effector molecules of the HPA axis and are essential for cutaneous homeostasis. Atopic dermatitis (AD) is a condition typically characterized by a chronic relapsing course that often results in PS. HPA dysfunction is present in AD patients by the decreased response of GCs elevation to stress as compared to those unaffected by AD. Nevertheless, in skin, acute PS activates several metabolic responses that are of immediate benefit to the host. During the acute phase of PS, increased endogenous GCs have been shown to provide benefit rather than by aggravating cutaneous inflammatory dermatoses. However, a chronic T helper cell type 2 (Th2) predominant cytokine profile acts as a negative feedback loop to blunt the HPA axis response in AD. In this article, we reviewed the role of CRF, pro-opiomelanocortin (POMC)-derived peptides, GCs of the HPA, and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in AD, with a discussion of the pathogenetic mechanisms of inflammation and skin barrier functions, including antimicrobial defense, and their association with PS.

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“…In epidermal keratinocytes, CRH inhibits proliferation by arresting cells at the G0/1 cycle, and induces differentiation by calcium influx and AP-1 transcription pathway [30, 31]. MAPK pathway and VEGF down-regulation was proposed to be a possible mechanism [32]. In dermal fibroblasts and melanocytes CRH acts as growth factor stimulating proliferation.…”

Section: Stress Mediators and Effector Cellsmentioning

confidence: 99%

Brain-Skin Connection: Stress, Inflammation and Skin Aging

Chen

Lyga²

2014

IADT

186

161

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The intricate relationship between stress and skin conditions has been documented since ancient times. Recent clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases. However, the exact underlying mechanisms have only been studied and partially revealed in the past 20 years or so. In this review, the authors will discuss the recent discoveries in the field of “Brain-Skin Connection”, summarizing findings from the overlapping fields of psychology, endocrinology, skin neurobiology, skin inflammation, immunology, and pharmacology.

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Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes

Cited by 18 publications

References 58 publications

A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress‐induced mitogen‐activated protein kinase signalling in rats

A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress‐induced mitogen‐activated protein kinase signalling in rats

Association between Stress and the HPA Axis in the Atopic Dermatitis

Brain-Skin Connection: Stress, Inflammation and Skin Aging

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