Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

Makrigiannakis, Antonis; Zoumakis, Emmanouil; Kalantaridou, Sophia Ν.; Coutifaris, Christos; Margioris, Andrew N.; Coukos, George; Rice, Kenner C.; Gravanis, Achille; Chrousos, George P.

doi:10.1038/ni719

Cited by 225 publications

(232 citation statements)

References 46 publications

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“…These fi ndings suggest that CRH binding to its cognate receptor is involved in both implantation and early pregnancy immune tolerance [116] . CRH levels increase during gestation and at term; high concentrations of placental CRH (pCRH) are present in maternal and fetal blood, including the amniotic fl uid [113,116] . CRH activity in maternal plasma is attenuated by the presence of a circulating CRH-binding protein (CRH-BP) produced by the liver and placenta.…”

Section: Placental Crhmentioning

confidence: 84%

Section: Placental Crhmentioning

confidence: 99%

“…Furthermore, animal studies have shown that the rat endometrium and the adjacent trophoblast-implantation site contain CRH concentrations 3.5-fold higher than the inter-implantation regions during early pregnancy [116] . These fi ndings suggest that CRH binding to its cognate receptor is involved in both implantation and early pregnancy immune tolerance [116] .…”

Section: Placental Crhmentioning

confidence: 99%

“…Cellular studies show that epithelial cells constitute the primary source of endometrial CRH [113] and its cognate receptor, CRH-R1 [114] , is widely distributed in epithelial and stromal cells of the human endometrium [113,115] and myometrium [111] . During stromal decidualization, progestins stimulate the expression of endometrial CRH in a cAMP-dependent manner [115] , resulting in the production of large amounts of CRH [114,116] .Furthermore, animal studies have shown that the rat endometrium and the adjacent trophoblast-implantation site contain CRH concentrations 3.5-fold higher than the inter-implantation regions during early pregnancy [116] . These fi ndings suggest that CRH binding to its cognate receptor is involved in both implantation and early pregnancy immune tolerance [116] .…”

mentioning

confidence: 99%

“…During stromal decidualization, progestins stimulate the expression of endometrial CRH in a cAMP-dependent manner [115] , resulting in the production of large amounts of CRH [114,116] .…”

mentioning

confidence: 99%

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Hypothalamic-pituitary-adrenal axis function during perinatal depression

et al. 2015

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Abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.Keywords: brain; depression; neuroendocrine; pregnancy; stress; glucocorticoids Extensive studies have demonstrated that early life stressors produce changes in behavior and enhance the sensitivity of the stress response systems [1][2][3][4] . Although the genetic background has been implicated in the development of mood-related disorders, and genetic research has identified some chromosomal regions and genes that are involved in susceptibility to mood disorders, the etiology of anxiety and depressive disorders is still not clear in humans, particularly in women with major depressive disorder (MDD) [1] .The pathogenesis of perinatal depression is an emerging field. Although considerable progress has been made in this area in the last few years, there still remain unanswered questions and gaps in our knowledge of the underlying pathogenesis, the long-term impact of perinatal depression on the developing fetus, and the best methods for counseling pregnant women concerning the risks of untreated MDD versus the risks of psychopharmacologic treatment during pregnancy and lactation [5] . Meta-analysis studies have reported that the mean prevalence rate of prenatal depression is ~12% (this varies greatly according to location, mode of assessment, and socioeconomic conditions), and show that a large percentage of pregnant women displaying major depression remain depressed in the postpartum period and/or continuously [6,7] . Anxiety, depressive disorder, and stress during pregnancy are risk Phillipe Leff Gelman, et al. HPA axis in perinatal depression 339 factors for negative outcomes in newborns, like preterm birth or low birth weight; also, insecure attachment and impaired child development could be a consequence of mental disorders during pregnancy [6,[8][9][10] . The mechanisms by which maternal depression impacts fetal and neonatal development are currently under investigation; there is some evidence that depressive symptoms impact the infant's hypothalamic-pituitary-adrenal (HPA) axis, enhancing the ...

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Section: Placental Crhmentioning

confidence: 84%

Section: Placental Crhmentioning

confidence: 99%

Section: Placental Crhmentioning

confidence: 99%

mentioning

confidence: 99%

“…During stromal decidualization, progestins stimulate the expression of endometrial CRH in a cAMP-dependent manner [115] , resulting in the production of large amounts of CRH [114,116] .…”

mentioning

confidence: 99%

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Hypothalamic-pituitary-adrenal axis function during perinatal depression

et al. 2015

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Maternal Tolerance

2004

Encyclopedic Dictionary of Genetics, Genomics and Proteomics

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An insight into the role of the death receptor CD95 throughout pregnancy: Guardian, facilitator, or foe

Sagrillo-Fagundes¹,

Bienvenue-Pariseault²,

Legembre

et al. 2019

Birth Defects Research

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The prototype death receptor CD95 (Fas) and its ligand, CD95L (FasL), have been thoroughly studied due to their role in immune homeostasis and elimination of infected and transformed cells. The fact that CD95 is present in female reproductive cells and modulated during embryogenesis and pregnancy has raised interest in its role in immune tolerance to the fetoplacental unit. CD95 has been shown to be critical for proper embryonic formation and survival. Moreover, altered expression of CD95 or its ligand causes autoimmunity and has also been directly involved in recurrent pregnancy losses and pregnancy disorders. The objective of this review is to summarize studies that evaluate the mechanisms involved in the activation of CD95 to provide an updated global view of its effect on the regulation of the maternal immune system. Modulation of the CD95 system components may be the immune basis of several common pregnancy disorders.

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Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

Cited by 225 publications

References 46 publications

Hypothalamic-pituitary-adrenal axis function during perinatal depression

Hypothalamic-pituitary-adrenal axis function during perinatal depression

Maternal Tolerance

An insight into the role of the death receptor CD95 throughout pregnancy: Guardian, facilitator, or foe

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