Cortisol and polycystic ovarian syndrome – a systematic search and meta-analysis of case–control studies

Benjamin, Jiby Jolly; Maheshkumar, K; Koshy, Teena; Narayana, Maruthy Kalburgi; Padmavathi, R

doi:10.1080/09513590.2021.1908254

Cited by 15 publications

(9 citation statements)

References 50 publications

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“…It is well-established that abnormally low testosterone inhibits growth of small growing follicles, which then leads to reductions in granulosa cell mass and AMH levels [ 11 ]. However, this might not be true for women with PCOS, where high AMH is a marker of disease severity and likely the main disruptor of normal ovarian function [ 12 ] and usually higher cortisol levels are found than in controls [ 13 ]. In fact, we will not be sure about the changes which happen in women who develop FHA until we will be able to acquire longitudinal data.…”

Section: Discussionmentioning

confidence: 99%

Stress and polycystic ovarian morphology in functional hypothalamic amenorrhea: a retrospective cohort study

Hager

Dewailly

Marculescu

et al. 2023

Reprod Biol Endocrinol

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Background Women with functional hypothalamic amenorrhea (FHA) reveal polycystic ovarian morphology (PCOM) in up to 50%. If stress sensitivity in women with polycystic ovary syndrome (PCOS) is the reason why PCOS women are prone to develop FHA, patients with FHA caused by stress should reveal PCOM more often. Methods In a retrospective cohort study, 38 stress-associated and 38 excessive exercise-induced FHA women were included. The main outcome parameter was PCOM. In addition, the focus was on general patient characteristics as well as on prolactin, dehydroepiandrosterone-sulphate (DHEAS), and anti-Mullerian hormone (AMH). Results PCOM was found in 34/76 patients (44.7%). The stress group showed a higher prevalence of PCOM than the excessive exercise group (57.9% versus 31.6%, p = 0.019) as well as higher prolactin levels (median 13.2ng/mL versus 11.7ng/mL, p = 0.008) and a trend towards higher DHEAS levels (p = 0.058). Conclusions In FHA women, the PCOM prevalence was significantly higher in the stress-group than in the excessive exercise-group. The well-known stress sensitivity in women with PCOS might explain why PCOS women are prone to develop FHA as well as the high PCOM prevalence in FHA women.

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Section: Discussionmentioning

confidence: 99%

Stress and polycystic ovarian morphology in functional hypothalamic amenorrhea: a retrospective cohort study

Hager

Dewailly

Marculescu

et al. 2023

Reprod Biol Endocrinol

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“…Other stress markers have also been studied under meta-analysis in PCOS. A meta-analysis that linked cortisol with PCOS showed overall elevation of cortisol levels in PCOS subjects [ 15 ]. This suggested that stress was appreciably related to this disease.…”

Section: Discussionmentioning

confidence: 99%

“…As these studies did not depict clear association in any direction, a systematic review and meta-analysis was purposed to study the association of DHEA with PCOS from the existing body of evidence. Similar meta-analyses were also done to find the association of inflammatory genes with female infertility disorders [ 14 ] as well as cortisol with PCOS [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

et al. 2021

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Background Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal. Objective To perform meta-analysis and find the association between stress and the syndrome. Data sources Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms. Study selection Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles. Data extraction Two authors independently extracted the articles and qualified the final studies. Data synthesi Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59–1.71).Heterogeneity was statistically significant as well (I2 = 95%). Conclusion Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.

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“…Yoga treatment expands alpha waves and diminishes serum cortisol levels responsible for stress reduction 29 . In the meta-analysis of forty-one studies on PCOS by Jiby Jolly Benjamin et al, they found significantly higher cortisol levels in PCOS patients than in healthy women 30 . Psychological stress is directly proportional to the glycaemic index.…”

Section: Discussionmentioning

confidence: 99%

Narrative Review on the Role of Yoga on Polycystic Ovary Syndrome

Mirase

Kuchewar

Parwe

2023

Int J Life Sci Pharm Res

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PCOS is an endocrine condition affecting women of reproductive age. It is connected to a specific style of life. If treatment is put off, it lowers fertility and may result in serious new problems. The precise origin of polycystic ovarian syndrome is unknown because it is believed to be a complex metabolic disorder. It demonstrates infertility, obesity, hirsutism, acne, and menstrual disorders specifically. PCOS is treated based on how it presents clinically at different phases of life. Women with polycystic ovarian syndrome reported feeling more anxious than women in good health. The estimated range for PCOS prevalence worldwide is 6-26%. Depending on the menstrual, androgen, and infertility clinical characteristics, a therapeutic strategy is chosen. Current medical practises are unsatisfactory. For polycystic ovarian syndrome, alternative therapies are helpful, including herbal medicine, a nutritious diet, lifestyle changes, exercise, yoga, and techniques for reducing stress. A key component of PCOS treatment is lifestyle management. The best way to change one's lifestyle is to adopt yoga. Through the establishment of homeostasis, yoga helps the individual become healthy. The eight-limbed path of Ashtanga yoga promotes psycho-somatic equilibrium. At present, yoga, entails physical postures called asanas, breathing exercises called pranayam, and meditation called dhyana (Meditation). Yoga has the potential to be both preventative and curative, according to scientific data. It works well as a supportive treatment for PCOS patients to enhance their quality of life. Thus, the focus of this review is on defining the function of yoga in the treatment of PCOS. This review included all of the studies that looked at the impact of yoga on PCOS patients. Data search revealed substantially less literature on yoga and PCOS, although the six original studies indicated support for yoga's importance in PCOS management. It has an impact on overtly contributory factors such stress, insulin resistance, and obesity.

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Cortisol and polycystic ovarian syndrome – a systematic search and meta-analysis of case–control studies

Cited by 15 publications

References 50 publications

Stress and polycystic ovarian morphology in functional hypothalamic amenorrhea: a retrospective cohort study

Stress and polycystic ovarian morphology in functional hypothalamic amenorrhea: a retrospective cohort study

DHEA and polycystic ovarian syndrome: Meta-analysis of case-control studies

Narrative Review on the Role of Yoga on Polycystic Ovary Syndrome

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