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Background Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal. Objective To perform meta-analysis and find the association between stress and the syndrome. Data sources Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms. Study selection Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles. Data extraction Two authors independently extracted the articles and qualified the final studies. Data synthesi Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59–1.71).Heterogeneity was statistically significant as well (I2 = 95%). Conclusion Thismeta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.

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Background: Blood group plays a unique role in revealing the identity of an individual. Several studies have expressed variations in bleeding tendencies among individuals with various ABO blood groups. Hence a study was done to the find association of bleeding and clotting time with this blood group. Materials and Methods: This study had a cross-sectional study design and was done among 250 young adults. Slide agglutination method was used to assess ABO blood group; while Dukes and capillary tube method were used to determine bleeding and clotting time respectively. Chi-square analysis was done to analyze its association with blood group. Results: Blood group O (38.4%) was found to be the major blood group among both genders, followed by B (34%), A (19.2%), AB (0.08%). Bleeding time of more than 4 minutes was found in both O and B group but the result was statistically not significant (p=0.85). Clotting time of more than 6 minutes was found again in both O and B groups and the difference was not significant (p=0.96). Bleeding time was found to be higher in males while Clotting time was found to be more prolonged in females however the difference was statistically less significant (p>0.05). Conclusion: In this study, results have shown that blood group O was the predominant blood group among the study population and blood group O and B had prolonged bleeding and clotting time compared to other groups. Based on gender, females had higher clotting time compared to males.

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