Cortisol levels in human pregnancy in relation to parity and age

Vleugels, M.P.H.; Eling, W.M.C.; Rolland, R.; Graaf, Robin de

doi:10.1016/0002-9378(86)90092-x

Cited by 36 publications

(20 citation statements)

References 10 publications

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“…This might be explained by the relative youthfulness of our sample, ranging from 16 to 44 years of age, in which the proposed 'age-related increase in HPA axis activity' is not apparent yet. We also found higher cortisol levels in nulliparous women compared to multiparous women, which is a replication of earlier findings (Vleugels et al 1986;Conde & Figueiredo 2014). Self-reported pre-pregnancy BMI was inversely associated with cortisol.…”

Section: Biological Factorssupporting

confidence: 89%

“…Pregnancy itself has been stated a 'controlled inflammatory process' in which cortisol and CRP levels are correlated, allowing an appropriate environment to allow pregnancy, and dysregulation might result in adverse obstetric outcomes (Wilder 1998, Mor & Cardenas 2010. In pregnancy, higher cortisol levels were found in nulliparous women compared to multiparous women (Vleugels et al 1986;Conde & Figueiredo 2014), and lower cortisol levels were reported in women with a higher body mass index (BMI) . Furthermore, environmental factors such as smoking behavior also appear to influence cortisol levels (Dušková et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…The current study aimed to include several maternal biological, lifestyle and psychosocial factors in our analysis, possibly identify novel determinants, and assess the contribution of psychosocial stress when all other factors are taken into account. We looked at different subgroups to compare directions and effect sizes according to ethnicity, employment and parity, which may interact with HPA-axis activity (Vleugels et al 1986;Rasheed 1993). We hypothesized that biological and environmental factors are more strongly associated with maternal cortisol levels than psychosocial factors, and that this may differ per subgroup.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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Please cite this article as: Bleker, Laura S., Roseboom, Tessa J., Vrijkotte, Tanja G., Reynolds, Rebecca M., de Rooij, Susanne R., Determinants of Cortisol During Pregnancy − the ABCD Cohort.Psychoneuroendocrinology http://dx.doi.org/10. 1016/j.psyneuen.2017.05.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. later adverse health consequences. However, evidence linking maternal stress to maternal cortisol values during pregnancy is inconclusive. A possible explanation for this is that other maternal factors overshadow any potential effects of stress on cortisol levels. We studied a large cohort of pregnant women with extensive data on pregnancy characteristics to determine the respective contributions of biological, environmental and psychosocial stress factors to cortisol levels in pregnancy. Methods:We used data from 3039 women from the Amsterdam Born Children and their Development-study cohort. Serum cortisol was measured in blood, collected at the first prenatal visit, at different gestational ages (median=91 days, range=40-256 days), and at various time points during the day (median=11:45h, range=08:00 -18:30h). We assessed associations between maternal serum cortisol in pregnancy and biological factors, lifestyle factors and stress factors, including depression, anxiety, pregnancy-related anxiety, work stress, parenting stress and fatigue. Results:In multivariable analysis, variables that were associated with higher cortisol levels in pregnancy were lower maternal age [1.5 nmol/l, 95%CI (0.6 to 2. Conclusions: Our data suggest that maternal cortisol during pregnancy is mainly affected by biological and lifestyle factors, but not by psychosocial factors. We suggest that psychosocial stress in Laura S. Bleker 3 pregnancy might program the fetus through other mechanisms than through altering maternal cortisol levels.

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Section: Biological Factorssupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Determinants of cortisol during pregnancy – The ABCD cohort

Bleker

Roseboom

Vrijkotte

et al. 2017

Psychoneuroendocrinology

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“…Experimental studies comparing gestating and non-gestating infected mice confirm that gestation promotes inflammatory response to infection (such as TNF␣ production; Rivera et al, 1995) without modifying the course of infection (Carlier et al, 1987;Cardoni and Antunez, 2004a). However, as observed by our team but not by others (Salas et al, 2007), primiparity might be an additional factor contributing to parasite transmission, since, higher levels of cortisol (an immunosuppressive hormone) and lower levels of prolactin (an immunostimulatory hormone) are produced in primiparas compared to multiparas (Vleugels et al, 1986). Of interest, infected mothers with fewer previous pregnancies produced less IFN-␥ than did infected mothers with more previous pregnancies (Hermann et al, 2004), which might contribute to increase parasitemia and congenital transmission.…”

Section: 3supporting

confidence: 79%

Congenital Chagas disease as an ecological model of interactions between Trypanosoma cruzi parasites, pregnant women, placenta and fetuses

2015

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The aim of this paper is to discuss the main ecological interactions between the parasite Trypanosoma cruzi and its hosts, the mother and the fetus, leading to the transmission and development of congenital Chagas disease. One or several infecting strains of T. cruzi (with specific features) interact with: (i) the immune system of a pregnant woman whom responses depend on genetic and environmental factors, (ii) the placenta harboring its own defenses, and, finally, (iii) the fetal immune system displaying responses also susceptible to be modulated by maternal and environmental factors, as well as his own genetic background which is different from her mother. The severity of congenital Chagas disease depends on the magnitude of such final responses. The paper is mainly based on human data, but integrates also complementary observations obtained in experimental infections. It also focuses on important gaps in our knowledge of this congenital infection, such as the role of parasite diversity vs host genetic factors, as well as that of the maternal and placental microbiomes and the microbiome acquisition by infant in the control of infection. Investigations on these topics are needed in order to improve the programs aiming to diagnose, manage and control congenital Chagas disease.

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“…Non-specific immunosuppression and hormonal changes such as increased cortisol levels in primigravidae women have been implicated. 4 Although there is some evidence of a general immunosuppression in cellular immunity in pregnant women, 5 two studies have shown no difference in antibody responses to malaria antigens between pregnant and non-pregnant women. 6,7 Recent evidence suggest that gravidity-dependent changes in cytokine levels, 8 and the acquisition of antibodies that block parasite binding to the placenta could play an important role in protection against placental malaria.…”

Section: Introductionmentioning

confidence: 99%

Effects of Permethrin-Treated Bed Nets on Immunity to Malaria in Western Kenya I. Antibody Responses in Pregnant Women and Cord Blood in an Area of Intense Malaria Transmission

Kariuki¹,

Kuile²,

Wannemuehler³

et al. 2003

Am J Trop Med Hyg

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Abstract. As part of a community-based group-randomized trial on the impact of permethrin-treated bed nets (ITNs) on malaria in pregnancy in a holoendemic area of western Kenya, we assessed their effects on antibody responses to Plasmodium falciparum pre-erythrocytic antigens (recombinant circumsporozoite protein [CSP] and peptides complimentary to the repeat region of the liver stage antigen-1 [LSA-1]) and blood stage antigen (recombinant C-terminal domain of the merozoite surface protein-1 [MSP-1 19 kD]) in paired maternal/cord plasma samples obtained from 296 deliveries (157 from ITN villages and 139 control villages). Levels of total IgG and IgG subclasses 1−3 to LSA-1 and total IgG and IgG3 to MSP-1 were lower, whereas those of total IgG to CSP were significantly higher in women from ITN villages than those from control villages. In cord plasma, levels of total IgG and IgG2 to LSA-1 and IgG3 to MSP-1 were lower in ITN villages than in control villages, but antibody responses to CSP were similar. Our results suggest that the use of ITNs decreases antibody responses to LSA-1 and MSP-1 antigens in pregnant women with associated reductions in levels of the same antibodies in cord blood. In contrast, ITN use was found to be associated with increased antibody responses to CSP in pregnant women, but had no effect on antibody levels to CSP in cord blood.

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Cortisol levels in human pregnancy in relation to parity and age

Cited by 36 publications

References 10 publications

Determinants of cortisol during pregnancy – The ABCD cohort

Determinants of cortisol during pregnancy – The ABCD cohort

Congenital Chagas disease as an ecological model of interactions between Trypanosoma cruzi parasites, pregnant women, placenta and fetuses

Effects of Permethrin-Treated Bed Nets on Immunity to Malaria in Western Kenya I. Antibody Responses in Pregnant Women and Cord Blood in an Area of Intense Malaria Transmission

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