Corynebacterium Jeikeium Endocarditis

Gupta, Rahul; Popli, Tarun; Ranchal, Purva; Khosla, Jagjit; Aronow, Wilbert S.; Frishman, William H.; Khoury, Marc El

doi:10.1097/crd.0000000000000355

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…The genus Corynebacterium could be part of the human commensal flora that may or may not be responsible for bacteremia in an opportunistic manner. While this genus includes the agent responsible for diphtheria ( Corynebacterium diphteriae complex, responsible for a potentially fatal infection caused by this toxigenic strain) and while C. jeikeium and C. urealyticum are involved mainly in bacteremia and urinary tract infections, C. gottingense has been reported in only one case of bacteremia [ 15 , 16 , 17 , 18 ]. The context of the infection has not been described in the clinical data either.…”

Section: Discussionmentioning

confidence: 99%

First Bacteremia Due to Corynebacterium gottingense in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

et al. 2023

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Corynebacterium gottingense is a Gram-positive bacillus that has not been reported as pathogenic in pediatric patients. Herein, a case of catheter-associated bloodstream infection by C. gottingense in a 13-year-old immunocompromised child with febrile neutropenia induced for osteosarcoma is reported. The species was identified by Sanger sequencing of the 16s rRNA sequence of the bacterial strain and was compared phylogenetically with published sequences. As suggested in the literature, the presented strain was multi-susceptible, particularly to amoxicillin. The patient was treated with piperacillin/tazobactam for seven days in the context of a urinary co-infection, resulting in resolution of fever within 48 h and then relaunched with oral amoxicillin for 3 days (for a total of 10 days of antibiotic therapy). Phylogenetic analyses based on 16S rDNA demonstrated the complexity of the genus Corynebacterium spp. but failed to demonstrate a direct benefit in predicting clinical outcome based on this single information.

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Section: Discussionmentioning

confidence: 99%

First Bacteremia Due to Corynebacterium gottingense in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

et al. 2023

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“…In previous studies Corynebacterium spp. have been associated with CIED-associated endocarditis [7,8,[11][12][13][14][15]. In a study examining 30 IE episodes due to Corynebacterium spp., the median age of the patients was 71 years and 77% of them were male.…”

Section: Discussionmentioning

confidence: 99%

“…In a study examining 30 IE episodes due to Corynebacterium spp., the median age of the patients was 71 years and 77% of them were male. C. striatum (n=11) and C. jeikeium (n=5) were the most common species [12].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, Corynebacterium spp. defined into subtypes by using the VITEK 2 Compact (Biomerioux, France) automated system and the 16S rDNA sequence analysis methods [7,8,[11][12][13][14][15]. Our patient was a 55-year old man and the subspecies analysis could not be performed because such examinations could not be performed in our center.…”

Section: Discussionmentioning

confidence: 99%

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Corynebacterium endocarditis in a patient with a cardiac implantable electronic device

Alkan¹,

Küçük²,

ŞAHİN³

et al. 2022

Iberoam J Med

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Cardiac implantable electronic device (CIED) infections have been rising around the world. Many microorganisms can lead to this disease. Corynebacterium species are catalase-positive Gram-positive bacilli, also known as "diphtheroids" or "coryneform" bacteria, were once almost universally dismissed as contamination when recovered from patients, but they are now increasingly being linked to serious infections and have the ability to form biofilms and rarely cause CIED infections and this can be complicated as infective endocarditis. Corynebacterium spp. are frequently overlooked as contaminants in blood cultures, yet they can cause a serious infective endocarditis (IE). Antibiotic resistance is increasing among Corynebacterium spp., and this makes treatment more challenging. There are few reports of IE caused by Corynebacterium spp., and more research is needed. Here, we report a case of 55- year old man with Corynebacterium spp. cardiac device-related infective endocarditis.

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“…2,7,[11][12][13][14][15][16] There are also increasing reports on non-diphtheriae Corynebacterium-related UTIs, but most studies were case reports or focused on one species only. 8,14,[17][18][19][20][21] Very few studies have identified non-diphtheriae Corynebacterium involving infections at the species level. 13,22 The increase of clinical relevance, unpredictable antimicrobial susceptibilities to the currently available agents, as well as little understanding of potential drug resistance mechanisms all make it necessary to move forward in this line of research.…”

Section: Introductionmentioning

confidence: 99%

In vitro Studies of Non-Diphtheriae Corynebacterium Isolates on Antimicrobial Susceptibilities, Drug Resistance Mechanisms, and Biofilm Formation Capabilities

Sun¹,

Ma²,

Li³

et al. 2022

IDR

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Objective This study aimed to investigate the antimicrobial susceptibilities, drug resistance mechanisms, and biofilm formation capacities of non-diphtheriae Corynebacterium strains isolated from sterile midstream urine of hospitalized patients with clinical urinary tract infections (UTIs). Methods A total of 45 non-diphtheriae Corynebacterium isolates were recovered from sterile midstream urine. The available data of 45 patients were collected. Minimum inhibitory concentrations (MICs) of 10 commonly used antibiotics were determined. Meanwhile, the molecular resistance mechanisms of each agent were performed through PCR with specific primers. Moreover, the biofilm formation capability of each isolate on abiotic surfaces was detected with the MTT method. Results In this study, the most prevalent three species were C. striatum (15/45, 33.3%), C. glucuronolyticum (9/45, 20.0%) and C. urealyticum (8/45, 17.8%). These three species also accounted for most renal and ureteral calculi cases. Male patients older than 50 years, especially those with underlying diseases, were more susceptible to non-diphtheriae Corynebacterium infection. All the 45 isolates were 100% susceptible to vancomycin and linezolid, but highly resistant to macrolide–lincosamide–streptogramin B (MLSB), fluoroquinolones, tetracyclines and β-lactams with corresponding mechanisms. The detection rate of multidrug–resistant (MDR) non-diphtheriae Corynebacterium is 91.1%. All isolates are able to form biofilm on abiotic surfaces, except those of C. urealyticum, C. tuberculostearicum and C. jeikeium . Isolates of C. glucuronolyticum and C. Striatum possessed the strongest biofilm formation capacity. C. amycolatum could form biofilm, but varied greatly among different isolates. Conclusion C. striatum, C. glucuronolyticum and C. urealyticum were the most prevalent species relevant to UTIs. The high occurrence of MDR isolates and high diversities in resistance profiles, and the distinctive abilities of biofilm formation highlighted the urgency for identification to species level. We should pay more attention to the drug resistance profiles of non-diphtheriae Corynebacterium , which would help improve empirical antibiotic therapy and reduce drug resistance transmission.

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Corynebacterium Jeikeium Endocarditis

Cited by 10 publications

References 34 publications

First Bacteremia Due to Corynebacterium gottingense in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

First Bacteremia Due to Corynebacterium gottingense in an Immunocompromised Child: A Case Report, 16S rDNA-Based Phylogenetic Analyses and Review of the Literature

Corynebacterium endocarditis in a patient with a cardiac implantable electronic device

In vitro Studies of Non-Diphtheriae Corynebacterium Isolates on Antimicrobial Susceptibilities, Drug Resistance Mechanisms, and Biofilm Formation Capabilities

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