CoSe₂ Nanoparticles with Multienzymic Activities for Antibacterial Applications

Abstract

Increasing bacterial resistance has led to the aggravation of diseases caused by microbial infections, posing a significant threat to human health. The multicascade approach is more efficient than a single treatment for resistant bacteria. Here, we describe the simple method of fabricating CoSe 2 nanoparticles, which operate as a single-component, multienzyme-mimicking nanoplatform for multiple ROS production. The nanoplatform simultaneously exhibits multienzymatic activities that mimic intrinsic catalase, peroxidase, and oxidase. Furthermore, under the synergistic action of 808 nm NIR, the multienzyme cascade action and ROS produced by photodynamics play a stronger role against drug-resistant extended-spectrum β-lactamase-producing Escherichia coli. Therefore, this study reveals the potential of CoSe 2 nanoparticles as efficient antimicrobial reagents, providing a promising alternative nanozyme for biomedical use.

Vancomycin-Loaded Porphyrinic MOF Nanoparticles for Killing Pathogenic Bacteria

“…Bacterial infection has become one of the most serious threats to human health in the world, which induces a huge medical and financial burden to our society. − Antibiotics are considered a good choice to combat bacterial infection. Undoubtedly, the application of antibiotics has reduced morbidity and mortality significantly. − However, in the past few decades, the overuse and abuse of antibiotics has led to the constant emergence of drug-resistant bacterial strains, − and antibiotics have become less effective .…”

Ultralow Loading Copper-Intercalated MoO3 Nanobelts with High Activity against Antibiotic-Resistant Bacteria

“…The catalase activity of MoO 3−x /Cu was assessed by the change in fluorescence intensity of EuTc-HP at 620 nm produced by the combination of H 2 O 2 and europium tetracycline (EuTc). 47 In addition, oxygen produced by CAT-like activity in the presence of nanoenzymes was further assayed using a dissolved oxygen instrument. 48 Supporting Information provides detailed information.…”

“…48 EuTc-based fluorometric assay was used to study the catalase-like activity of the samples. 47 EuTc and H 2 O 2 can generate a europium tetracycline-hydrogen peroxide complex (EuTc-HP) with enhanced fluorescence intensity at 620 nm. Nanoenzymes with CAT-like activity can decompose H 2 O 2 , and the synthesis of EuTc-HP decreases, which leads to a weakening of the fluorescence intensity.…”

Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences

“…However, recent studies have revealed that Co‐based nanozymes can possess photothermal properties that respond to NIR (808 nm), which have already been shown to be effective in more efficient antibacterial applications. [ 99 ] Nonetheless, the photothermal conversion performance of these nanozymes is currently insufficient to realize photothermal therapy (PTT) of tumors. Consequently, exploring the mechanisms and enhancing the photothermal properties of these nanozymes can pave the way for expanding their applications.…”

“…In this context, CoSe 2 nanoparticles synthesized by Xu and colleagues exhibited simultaneous CAT‐like, POD‐like, and OXD‐like activities. [ 99 ] Furthermore, the photodynamic multienzyme cascade and ROS generated by these nanoparticles significantly inhibit drug‐resistant, broad‐spectrum β ‐lactamase‐producing Escherichia coli under the synergistic influence of 808 nm near‐infrared radiation.…”