Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis

Novembre, Elio; Galli, Elena; Landi, Fabiola; Caffarelli, Carlo; Pifferi, Massimo; Marco, Emanuela De; Burastero, Samuele E.; Calori, Giliola; Benetti, Luca; Bonazza, Paolo

doi:10.1016/j.jaci.2004.07.012

Cited by 445 publications

(326 citation statements)

References 42 publications

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“…Natural course of allergic disease. Sublingual immunotherapy may also impact the natural course of the disease (1730,1731), but more data are needed for confirmation.…”

Section: Sublingual Immunotherapymentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,859

1,761

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“…Natural course of allergic disease. Sublingual immunotherapy may also impact the natural course of the disease (1730,1731), but more data are needed for confirmation.…”

Section: Sublingual Immunotherapymentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,859

1,761

View full text Add to dashboard Cite

“…However, this is yet to be substantiated. Regarding sublingual immunotherapy, some randomized controlled open trials in children have also suggested a preventive asthma effect [85][86][87]. As the quality of pediatric evidence in this area is not optimal, there is a need for well-designed, double-blind, placebo-controlled studies to assess the longterm immunotherapy effects in childhood [88].…”

Section: Allergen-specific Immunotherapymentioning

confidence: 99%

Pediatric Allergic Rhinitis and Asthma: Can the March be Halted?

et al. 2013

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The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of 'united airways disease' or 'respiratory allergy', implying that allergy, in its widest sense, underlies this clinical syndrome. Progression from AR to asthma is frequent and part of the 'atopic march'. Since pediatric immune responses are more adaptable and therefore may be more amenable to treatment, interventions at early childhood are characterized by a higher chance to affect the natural history of respiratory allergy. Although current treatments are quite effective in alleviating respiratory allergy symptoms, it has proven much more difficult to confirm any influence on the progression of the disease. Much more promising is the field of specific allergen immunotherapy, where current evidence, although not yet of ideal robustness, points towards a disease-modifying effect. In addition, newer or emerging, possibly more effective or more targeted interventions are promising in the preventive sense.

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“…The safety profile seems not to be different in very young children (7,8). Similarly to injection immunotherapy, the literature would suggest that SLIT is capable of preventing the onset of new sensitizations and of reducing the risk of asthma onset in pediatric patients with allergic rhinitis (9,10). The most recent controlled trials (11)(12)(13)(14)(15)(16), involving hundreds of subjects, have clearly demonstrated, at least for grass pollen, a clinical efficacy over placebo far greater than the recommended 20% (17), in addition to a dosedependent effect.…”

Section: Introductionmentioning

confidence: 99%

Administration regimens for sublingual immunotherapy to pollen allergens: What do we know?

Lombardi

Incorvaia²,

Braga

et al. 2009

Allergy

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The modalities of administration of sublingual immunotherapy (SLIT), including dosing, build‐up phase, duration of the treatment, and frequency of the maintenance dose are largely variable. In the case of pollen (SLIT), the complexity increases, since preseasonal, coseasonal and pre‐coseasonal regimens can be used. The administration regimens are of relevance from a practical point of view, but can also have economic implications. We review herein the available literature (randomized double blind controlled studies) on pollen SLIT, in order to derive experimentally‐supported suggestions about the regimens of administration that should be preferred.

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Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis

Cited by 445 publications

References 42 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Pediatric Allergic Rhinitis and Asthma: Can the March be Halted?

Administration regimens for sublingual immunotherapy to pollen allergens: What do we know?

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