Cosinor Analysis of Feed Intake Cycle of Rats Fed a Zinc-Deficient Diet and the Effect of Zinc Supplementation.

Aiba, Keisuke; Kimura, Masahiro; Sakata, Shigeko Fujimoto; Matsuda, Koichi; Kaneko, Masae; Onosaka, Satomi; Yamaoka, Yumiko; Tamaki, Nanaya

doi:10.3177/jnsv.43.327

Cited by 11 publications

(19 citation statements)

References 21 publications

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“…The amplitude of the food intake cycle is correlated and inversely correlated to the addition of Zn to a Zn-deficient diet (1, 13) and a subcutaneous injection (14), respectively. The level of values (MϪA) on the bottom of the feed intake cycles is decreased but the values of the average food intake (M) are increased by addition of various concentrations of Zn (13,14). These results suggest that the ability to perceive a negative energy balance following action for food intake may depend on the level of Zn in rats and may relate to a retardation of growth in the Zn-deficient rats.…”

Section: Discussionmentioning

confidence: 72%

“…The daily food intake of Zn-deficient rats is lower than that of control rats and the reduced food intake is the result of the failure of the rats to eat food and not the result of a reduction in the amount consumed when the rats eat ( 7 ). The cyclical variation in food intake in rats was accompanied by a cyclical variation in body-weight in rats fed a Zn-deficient diet, which also occurred in pair-fed control rats ( 13 ).…”

mentioning

confidence: 85%

“…The daily food intake of rats fed a Zn-deficient diet shows a characteristic variation and fits well to a cosine curve (12)(13)(14). But force-feeding Zn-deficient rats with 140% of their voluntary intake rapidly induces severe signs of illness ( 5 ).…”

mentioning

confidence: 94%

“…Daily food intake and body weight change data from Zn-deficient rats were analyzed by the Cosinor method (12)(13)(14). Food intake ( F ) and body weight change ( ⌬ B ) on day t were determined using the following equation:…”

Section: Methodsmentioning

confidence: 99%

“…A reduction of the protein content of the Zn-deficient diet from 20 to 5% results in no effect on food intake and disappearance of the cyclical pattern of intake ( 5 , 7 , 21 ). The value of the amplitude is decreased and the mesor is increased with increasing Zn supplementation by oral feeding ( 13 ) and subcutaneous injection ( 14 ) in the food intake cycle of Zn-deficient rats. When Zn deficient rats selected a diet from glucose and fructose diets with a two-choice method ( 22 ) and from dextrin, maltose and glucose diets with a three choice method ( 23 ), some rats changed their preference in the course of the experimental periods but the total daily food intake of the rats continued to show a 3.5-4.0 d-cycle ( 22 , 23 ).…”

mentioning

confidence: 99%

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Change to a Preference for Maltose from Sucrose over Days in Zn-Deficient Rats Selecting from Maltose and Sucrose Diets

Horikawa

Yamamoto

Matsuda

et al. 2009

J Nutr Sci Vitaminol

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Summary This paper describes a preference for two disaccharides in the diets of Zn-adequate and Zn-deficient rats. Maltose and sucrose were used as a source of carbohydrate in the diet and the selection patterns of rats were analyzed for 28 d by a two-choice selection method. Diets provided as a set of two either Zn-adequate or Zn-deficient diets were changed in position daily. Control Zn-adequate and Zn-deficient rats both exclusively selected the sucrose diet at days 1 and 2, after onset of the feeding experiment, and then gradually selected the maltose-diet. After changing their preference from sucrose to maltose, the Znadequate control rats selected widely from both the maltose and sucrose diets, while the Zndeficient rats exclusively and continuously selected the maltose diet from the two diets over the experimental period. The level of selection of sucrose-diet on day 28 had a correlation with the intestinal sucrase activity in the control rats. The sum of daily maltose and sucrose diet intake in rats fed a Zn-deficient diet showed a characteristic variation with the cyclic period of 3.6 Ϯ 0.2 d. The daily body-weight change of rats fed a Zn-deficient diet was well synchronized with their own food intake cycle. The day before changing preference from sucrose to maltose in rats fed a Zn-deficient diet represented a trough in their own food intake and body-weight cycles. These results suggest that one sign of a change in preference from sucrose to maltose in Zn-deficient rats is caused by a stage of negative energy balance.

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Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 85%

mentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Change to a Preference for Maltose from Sucrose over Days in Zn-Deficient Rats Selecting from Maltose and Sucrose Diets

Horikawa

Yamamoto

Matsuda

et al. 2009

J Nutr Sci Vitaminol

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Stickstoffdetoxifikation bei kunstlich ernahrten Zn-Mangelratten

Roth

2001

J Anim Physiol Anim Nutr

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Development of Alimentary Zinc Deficiency in Growing Rats Is Retarded at Low Dietary Protein Levels

Roth

2003

The Journal of Nutrition

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The aim of the present study was to determine whether the level of dietary protein would influence the onset of zinc deficiency in rats because zinc-deprived rats have problems metabolizing dietary protein. Young male Sprague-Dawley rats were fed isoenergetic Zn-deficient diets (0.8 mg Zn/kg diet) or control diets substituted with zinc sulfate (54 mg Zn/kg diet) and protein levels of 2, 5, 8, 10, 15, 20 or 25 g/100 g for 21 d to determine whether changing the protein level of Zn-deficient diets affects the Zn status of the rats. In rats fed low dietary protein levels of 2 and 5%, feed intake, growth and appearance did not differ between the Zn-deficient rats and the control rats because the low zinc requirement was met by mobilization of zinc from the skeleton. At higher dietary protein levels, the Zn-depleted rats developed marked signs of Zn deficiency and had reduced feed intake, growth, alkaline phosphatase activity in the serum and Zn concentrations in serum and femur compared with the control rats. The reduced feed intakes and decreased growth of Zn-depleted rats fed high dietary protein levels (20 and 25%) compared with control rats may be due to disturbed protein synthesis, as demonstrated by the increased activities of alanine aminotransferase, glutamate dehydrogenase and carbamoylphosphate synthetase in the liver. Zinc as an essential component of the diet is thus vital for the efficient utilization of dietary protein.

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Cosinor Analysis of Feed Intake Cycle of Rats Fed a Zinc-Deficient Diet and the Effect of Zinc Supplementation.

Cited by 11 publications

References 21 publications

Change to a Preference for Maltose from Sucrose over Days in Zn-Deficient Rats Selecting from Maltose and Sucrose Diets

Change to a Preference for Maltose from Sucrose over Days in Zn-Deficient Rats Selecting from Maltose and Sucrose Diets

Stickstoffdetoxifikation bei kunstlich ernahrten Zn-Mangelratten

Development of Alimentary Zinc Deficiency in Growing Rats Is Retarded at Low Dietary Protein Levels

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