Cosmeceuticals: peptides, proteins, and growth factors

Abstract

Recent research advances in the molecular and biochemical processes involved in wound healing and skin aging have led to the development of innovative cosmeceuticals that rely on peptides, proteins, and growth factors to enhance skin health. Although the long-term benefits of these products have not been fully tested and evaluated, evidence of the benefits derived from their use is steadily growing. This study describes the peptides, proteins, and growth factors that are most frequently used in cosmeceuticals and discusses their potential benefits and practical use in dermatology.

Applications and efficacy of platelet‐rich plasma in dermatology: A clinical review

“…As the name implies, PRP is an autologous blood‐derived product with a moderated platelet concentration and few leukocyte, avoiding the proinflammatory effects of the proteases and acid hydrolases contained in the white blood cells . And the growth factors in PRP can slow down skin aging with the mechanisms of chemoattractant for fibroblasts and macrophages, mitogen for fibroblasts, and synthesis of extracellular matrix components . The application and efficacy of PRP on musculoskeletal and maxillofacial injury repair, orthopedic surgery, and bone graft are experimented more than once; now, an increasing number of dermatological indications are proved to be feasible and effective.…”

The efficacy study of the combination of tripeptide‐10‐citrulline and acetyl hexapeptide‐3. A prospective, randomized controlled study

“…The acetyl hexapeptide‐3 mimics the N‐terminal end of SNAP‐25 protein. It competes with the natural protein for a position in the SNARE complex, which is essential for muscle contraction . Due to its high toxicity, botulin toxin is under strict medical control.…”

Cosmecéuticos. Indispensable para otorrinolaringólogos y cirujanos plásticos faciales.

“…La piel envejecida es más frágil y seca, susceptible a irritantes pero también a la penetración de moléculas más grandes. Los estudios sugieren que los factores de crecimiento de uso tópico si tienen un efecto de rejuvenecimiento cutáneo (3). Finalmente la fotoprotección promueve una piel más joven y menos foto-envejecida.…”

“…A pesar de no ser sometidos a evaluaciones tan exhaustivas como la industria farmacéutica, la evidencia científica sobre el beneficio del uso de cosmecéuticos continua en aumento (3). Estos tratamientos pueden disminuir la hiperpigmentación, las irregularidades en la textura de la piel y las arrugas que acompañan el fotoenvejecimiento.…”