Cosmetical treatments of connective tissue disorders

Arıca, Deniz Aksu

doi:10.1111/dth.12935

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…Its main advantage is the identical structure of the molecule in any living being, which minimizes the probability of immunogenicity [ 21 , 22 ]. So far, no single case of reactivation or stimulation of morphea was reported after administration of purified HA biosynthesized via bacterial fermentation [ 15 ]. The widespread use of HA in orthopaedics for intra-articular injections for many years serves as evidence of its safety profile [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…The isolated columns of ablated skin do not disrupt proper healing and they stimulate collagen remodelling and decrease the level of fibrosis marker transforming growth factor beta-1 (TGFβ1). This therapy leads to the degradation of the abnormal collagen in morphea lesions and the induction of normal collagen synthesis [ 15 , 41 ]. The superiority of this method in comparison with low dose UVA-1 was observed in 17 patients in the study by Shalaby et al [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…The literature provides reports on correction of facial defects in localized scleroderma (morphea, en coup de sabre, hemiatrophia faciei Parry-Romberg) using hyaluronic acid (HA) [ 10 – 12 ], polymethylmethacrylate [ 13 ], poly- l -lactic acid [ 14 ] and autologous fat [ 15 – 17 ] performed successfully and with no delayed type hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

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The Correction of Facial Morphea Lesions by Hyaluronic Acid: A Case Series and Literature Review

Owczarczyk‐Saczonek¹,

Kasprowicz-Furmańczyk²,

Kruszewska³

et al. 2020

Dermatol Ther (Heidelb)

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Introduction: The aim of the study is to assess the long-term safety and efficacy of hyaluronic acid (HA) administration in correction of facial morphea lesions and to review the literature on the subject. Morphea is a chronic inflammatory disease of the connective tissue which may lead to serious deformations. The lesions located on the face particularly affect patients' quality of life and self-esteem; thus, there is a demand for safe and effective methods of treatment. Case Presentation: The paper presents three female patients aged 16, 17 and 70 with facial morphea lesions who had HA preparation Juvéderm Ò Voluma or Volux, Vycross Ò technology, Allergan, injected. One of the patients had additionally fractional ablative CO 2 laser (FAL) therapy. Discussion: The literature provides reports on successful use of HA, polymethylmethacrylate and poly-L-lactic acid for the correction of facial defects in localized scleroderma. HA is a natural component of the extracellular matrix and it therefore minimizes the probability of immunogenicity. The application technique also plays an important role. On the other hand, FAL therapy leads to the degradation of the abnormal collagen and the induction of normal collagen synthesis. Conclusions: HA injection and combination of HA application with FAL are minimally invasive, effective and safe therapeutic options for patients suffering from morphea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Correction of Facial Morphea Lesions by Hyaluronic Acid: A Case Series and Literature Review

Owczarczyk‐Saczonek¹,

Kasprowicz-Furmańczyk²,

Kruszewska³

et al. 2020

Dermatol Ther (Heidelb)

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“…2). The authors then read each publication, and 5 were deemed irrelevant, only mentioning BT injection use in passing 45–49 . Authors were unable to obtain access to 1 publication through their institutions 50 .…”

Section: Methods Of Reviewmentioning

confidence: 99%

Long-term Effects of Repeated Botulinum Toxin Injection in Cosmetic Therapeutics

2021

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Background: Botulinum toxin (BT), a potent neurotoxin, has been used in clinical medicine since the 1970s for cosmetic and therapeutic purposes. Studies have consistently shown positive outcomes with a very limited adverse effect profile and a conventional understanding that results dissipate after 3 to 5 months. However, more recent evidence suggests that changes in muscle composition, function, and appearance persist for much longer, even years. To examine the potential implications of these findings on cosmetic use of BT injections in reduction of skin lines and wrinkles, we first needed to further our understanding of the current literature on long-term outcomes after repeated BT injections. Methods: A comprehensive review of the literature on long-term outcomes after repeated BT injections for cosmetic indications was performed. We evaluated the study designs, and results were compared. Results: A total of 22 publications met our inclusion criteria, of which 14 were clinical trials. Few studies extended outcome measurement past 6 months postinjection, and many were funded or supported by industry. However, the studies that extended follow-up saw persistent changes after BT injection, in some cases as far as 4 years postinjection. Conclusion:The current body of knowledge on the long-term results after repeated cosmetic BT injections is very limited, and the available literature provides insufficient evidence on how prolonged effects could alter clinical use of BT. Further clinical studies with extended follow-up periods with inclusion of both subjective and objective measured outcomes of appearance and muscle function are required to better understand the long-term impacts of repeated BT injections.

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“…In this field, medical treatments have often proved unsatisfactory and do not meet patients’ expectations of cosmetic outcome. Thus, it seems obvious that looking for safe and effective practices that correct aesthetic and functional deficits is highly desirable [ 10 , 11 ]. Due to advances in the application of lasers and their possible beneficial effects, the aim of this study is to review the reported usage of lasers in treating morphea.…”

Section: Introductionmentioning

confidence: 99%

Laser Therapy for the Treatment of Morphea: A Systematic Review of Literature

Szczepanik-Kułak

Michalska-Jakubus

Krasowska

2021

JCM

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Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients’ quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects. Due to the advances in the application of lasers and their possible beneficial effects, the aim of this study is to review the reported usage of laser in morphea. We present a systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, Web of Science, and Google Scholar databases. We identified a total of twenty relevant studies (MEDLINE n = 10, Cinahl n = 1, Central n = 0, Scopus n = 2, Web of Science n = 5, Google Scholar n = 2) using laser therapy for LoS. Eight studies were focused on the use of PDL, six on fractional lasers (CO2 and Er:YAG), four on excimer, and two on either alexandrite or Nd:YAG.

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Cosmetical treatments of connective tissue disorders

Cited by 5 publications

References 14 publications

The Correction of Facial Morphea Lesions by Hyaluronic Acid: A Case Series and Literature Review

The Correction of Facial Morphea Lesions by Hyaluronic Acid: A Case Series and Literature Review

Long-term Effects of Repeated Botulinum Toxin Injection in Cosmetic Therapeutics

Laser Therapy for the Treatment of Morphea: A Systematic Review of Literature

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