The usual account for the origin of cosmic structure during inflation is not fully satisfactory, as it lacks a physical mechanism capable of generating the inhomogeneity and anisotropy of our Universe, from an exactly homogeneous and isotropic initial state associated with the early inflationary regime. The proposal in [A. Perez, H. Sahlmann, and D. Sudarsky, Classical Quantum Gravity, 23, 2317, (2006)] considers the spontaneous dynamical collapse of the wave function, as a possible answer to that problem. In this work, we review briefly the difficulties facing the standard approach, as well as the answers provided by the above proposal and explore their relevance to the investigations concerning the characterization of the primordial spectrum and other statistical aspects of the cosmic microwave background and large-scale matter distribution. We will see that the new approach leads to novel ways of considering some of the relevant questions, and, in particular, to distinct characterizations of the non-Gaussianities that might have left imprints on the available data.