Cost and Effectiveness Evaluation of Prophylactic HPV Vaccine in Developing Countries

Termrungruanglert, Wichai; Havanond, Piyalamporn; Khemapech, Nipon; Lertmaharit, Somrat; Pongpanich, Sathirakorn; Khorprasert, Chonlakiet; Taneepanichskul, Surasak

doi:10.1016/j.jval.2011.11.007

Cited by 46 publications

(56 citation statements)

References 38 publications

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“…This local threshold is below the thresholds put forward by the WHO and has been used as a reference value in some vaccine evaluations for Thailand [13]. However, other studies evaluating HPV and rotavirus vaccination in Thailand have used the 'WHO-CHOICE thresholds' instead of the local threshold [14][15][16]. Again, these studies have often made a distinction between interventions that represent value for money (i.e.…”

Section: How Have the Who-choice Thresholds Been Used For Vaccines Inmentioning

confidence: 99%

Are Current Cost-Effectiveness Thresholds for Low- and Middle-Income Countries Useful? Examples from the World of Vaccines

2014

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The World Health Organization's CHOosing Interventions that are Cost Effective (WHO-CHOICE) thresholds for averting a disability-adjusted life-year of one to three times per capita income have been widely cited and used as a measure of cost effectiveness in evaluations of vaccination for low-and middle-income countries (LMICs). These thresholds were based upon criteria set out by the WHO Commission on Macroeconomics and Health, which reflected the potential economic returns of interventions. The CHOICE project sought to evaluate a variety of health interventions at a subregional level and classify them into broad categories to help assist decision makers, but the utility of the thresholds for within-country decision making for individual interventions (given budgetary constraints) has not been adequately explored. To examine whether the 'WHO-CHOICE thresholds' reflect funding decisions, we examined the results of two recent reviews of cost-effectiveness analyses of human papillomavirus and rotavirus vaccination in LMICs, and we assessed whether the results of these studies were reflected in funding decisions for these vaccination programmes. We found that in many cases, programmes that were deemed cost effective were not subsequently implemented in the country. We consider the implications of this finding, the advantages and disadvantages of alternative methods to estimate thresholds, and how cost perspectives and the funders of healthcare may impact on these choices.

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Section: How Have the Who-choice Thresholds Been Used For Vaccines Inmentioning

confidence: 99%

Are Current Cost-Effectiveness Thresholds for Low- and Middle-Income Countries Useful? Examples from the World of Vaccines

2014

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“…Recent studies on the use and efficacy of the HPV vaccine in developing countries have suggested that vaccine distribution could be an effective way to mitigate cervical cancer in low-and middle-income countries (Fesenfeld et al, 2013;Termrungruanglert et al, 2012). Demonstration projects in Peru, India, Uganda, and Vietnam have shown high levels of vaccination coverage using schoolbased programs targeting teen girls (LaMontagne et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Awareness of Human Papillomavirus (HPV), Cervical Cancer and HPV Vaccine among Women in Two Distinct Nepali Communities

Johnson

Bhatta²,

Gurung³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…With the goal to increase the HPV vaccination in mind, it is essential to set up HPV vaccination interventions which are well tailored for the young female population. Lastly, while the financial cost has been the major prohibitive factor to add the vaccine on the national vaccination program [31], more evidence has shown that the vaccine is cost effective compared to the cost of HPV and anogenital cancer treatments and damage to the quality of life [32,33]. In Thailand, the series of HPV vaccines cost between US$ 180 and US$ 340, while the gross national income per capita was approximately US$ 3,900 [33].…”

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confidence: 99%

Human papillomavirus (HPV) vaccination and factors related to intention to obtain the vaccine among young college women in Thailand

Ratanasiripong

Sriumporn

Kathalae

et al. 2018

JHR

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Purpose Most cervical cancers are caused by genital human papillomavirus (HPV). However, it can be prevented if females receive an HPV vaccine. Nevertheless, there is limited evidence of HPV vaccination and predictors of intention to obtain the vaccine among young women in Thailand. The paper aims to discuss this issue. Design/methodology/approach This cross-sectional study examined HPV vaccination and factors influencing intention to vaccinate among a convenient sample of college women in Thailand. The data collection was conducted via a self-administered “HPV and HPV vaccine-related knowledge, attitudes, and behaviors” questionnaire. Findings Out of 1,030 participants, 309 (30.0 percent) were aware of HPV and the HPV vaccine. Out of these, 257 participants reported that they had not obtained the vaccine and 18 participants were unsure if they had already obtained the vaccine or not. Only 34 participants confirmed that they had received the vaccine. Among those who were aware of HPV and the HPV vaccine, 56.4 percent of them did not know that most HPV-infected persons do not show any signs or symptoms, and 53.3 percent thought that the vaccine provided protection against other sexually transmitted infections as well. Most had positive attitudes toward vaccination and subjective norms. Among the participants who had not received the vaccine, the intention to obtain the vaccine was predicted by age, knowledge, attitudes toward vaccination, and subjective norms. The reasons for not being vaccinated included the cost of the vaccine, lack of knowledge, and perception of themselves being at low risk. Originality/value This study found low HPV vaccination among college women. However, those who had not received the vaccine intended to obtain the vaccine at some point in the future. An HPV vaccination campaign may be well tailored in order to increase the intention to obtain the vaccine which, in turn, may increase the HPV vaccination. Vaccination cost sharing should be discussed among Thai policy makers in order to alleviate the financial burden for women.

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Cost and Effectiveness Evaluation of Prophylactic HPV Vaccine in Developing Countries

Abstract: Compared with commonly accepted standard thresholds recommended by the World Health Organization Commission on Macroeconomics and Health, the nationwide coverage of HPV vaccination in girls is likely to be cost-effective in Thailand.

Cited by 46 publications

References 38 publications

Are Current Cost-Effectiveness Thresholds for Low- and Middle-Income Countries Useful? Examples from the World of Vaccines

Are Current Cost-Effectiveness Thresholds for Low- and Middle-Income Countries Useful? Examples from the World of Vaccines

Knowledge and Awareness of Human Papillomavirus (HPV), Cervical Cancer and HPV Vaccine among Women in Two Distinct Nepali Communities

Human papillomavirus (HPV) vaccination and factors related to intention to obtain the vaccine among young college women in Thailand

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