Cost–Benefit Analysis of Human Papillomavirus Vaccine in Iran

Sargazi, Nasrin; Takian, Amirhossein; Daroudi, Rajabali; Nahvijou, Azin; Yaseri, Mehdi; Motlagh, Ali Ghanbari; Zendehdel, Kazem

doi:10.1007/s10935-022-00697-w

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…Some studies reported that the quadrivalent vaccine has a higher cost-benefit ratio compared to the bivalent vaccine in Iran. However, it is important to consider other factors, such as vaccine efficacy and coverage rates, when making decisions about vaccination strategies in the country ( 48 , 77 ).…”

Section: Resultsmentioning

confidence: 99%

Cervical Cancer Prevention, Its Challenges and Solutions in Iran and Worldwide: A Systematic Review

Pirani,

Jafari,

Bagherzadeh

et al. 2023

ijph

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Background: Widespread use of screening in high-income countries has led to significant reductions in mortality from cervical cancer. However, in Iran, the main reason for the late diagnosis of cervical cancer was the failure to perform a Pap smear (Papanicolaou). We aimed to investigate the status of cervical cancer prevention and its challenges and solutions in Iran. Method: We conducted a systematic review of literature published from 1974 to 2021 in the electronic databases, including PubMed, Web of Science, Embase, Scopus, and Google Scholar, and retrieved all English-language articles. Following the application of the inclusion and exclusion criteria, full-text articles were identified and evaluated for eligibility. Finally, these publications were analyzed as part of the synthesis. Results: Lower social-economic level, inadequate knowledge of screening tests and health centers for Pap test performance leading to worse outcomes such as lower screening participation or coverage. Conclusion: By addressing these challenges through increasing education, increasing service accessibility, expanding screening programs, improving public awareness, improving insurance coverage, and establishing a control protocol for follow-up, it is possible to reduce cervical cancer incidence and mortality.

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Section: Resultsmentioning

confidence: 99%

Cervical Cancer Prevention, Its Challenges and Solutions in Iran and Worldwide: A Systematic Review

Pirani,

Jafari,

Bagherzadeh

et al. 2023

ijph

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“…We used the health care costs of treated and untreated persons in the CC states, which involved costs of hospitalization, medicaments, and CC treatments in Iran. Costs of vaccination consist of a two-dose quadrivalent vaccination and administration costs and was set at USD 152, which included an assumed USD 1 for administration [22]. Total health care treatment costs were estimated by dividing the total costs of CC treatment in Iran by the number of treated CC cases, and was set at USD 26,850 [22].…”

Section: Costsmentioning

confidence: 99%

“…Costs of vaccination consist of a two-dose quadrivalent vaccination and administration costs and was set at USD 152, which included an assumed USD 1 for administration [22]. Total health care treatment costs were estimated by dividing the total costs of CC treatment in Iran by the number of treated CC cases, and was set at USD 26,850 [22]. Costs were discounted with a rate of 3.5% [21].…”

Section: Costsmentioning

confidence: 99%

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Using a Dynamic Model to Estimate the Cost-Effectiveness of HPV Vaccination in Iran

Hagens,

Sloof,

Janghorban

2024

Vaccines

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This study aimed to determine the cost-effectiveness of vaccination against HPV. An age–sex structured dynamic disease transmission model was created to estimate the spread of HPV and the HPV-related incidence of cervical cancer (CC) in Iran. Sixteen age groups of men and women were incorporated to reflect the differences in sexual preferences, vaccination uptake, and disease-related outcomes. Three scenarios were evaluated by using an Incremental Cost-Effectiveness Ratio (ICER) with gained quality-adjusted life years (QALYs). ICER values below one gross domestic product (GDP) per capita are evaluated as highly cost-effective. Vaccination reduces the number of infections and CC-related mortality. Over time, the vaccinated group ages and older age groups experience protection. An initial investment is required and savings in treatment spending reduce the impact over time. Vaccinating girls only was found to be cost-effective, with an ICER close to once the GDP per capita. Vaccinating both sexes was shown to be less cost-effective compared to girls only, and vaccinating boys only was not found to be cost-effective, with an ICER between once and three times, and greater than three times the GDP per capita, respectively. The estimates are conservative since societal cost-saving and the impact of other HPV-related illnesses were not considered and would likely reduce the ICERs.

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The effect of education based on planned behavior theory on women’s knowledge and attitudes about human papillomavirus

Rafeie,

Vizeshfar,

Nick

2024

Sci Rep

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Human papillomavirus is the most common sexually transmitted infection in the world. Improving knowledge and attitude is the key to controlling and preventing, but women’s knowledge about this virus is not enough. This study aimed to determine the effect of educational intervention based on planned behavior theory on knowledge and attitude toward HPV and its vaccination in women of reproductive age. The study was a single-blind, randomized clinical trial study with a control group was done in 2022, which was conducted on 85 women referred to selected comprehensive health centers in Shiraz, Iran. In this study, the sampling was performed is a multi-stage random way. Eighty-three women who met the inclusion criteria were randomly divided into two intervention and control groups. The data collection tool was the knowledge and attitude questionnaire about HPV and its vaccine, which was confirmed to be valid and reliable. Data analysis was performed with descriptive and analytic statistics at a significance level of P < 0.05 with SPSS (22) software. The results showed that the educational intervention has caused a significant increase in the components of knowledge, attitude, social norms, perceived behavior control, and willingness to receive the HPV vaccine in the intervention group. So that in both stages after the intervention, there was a significant difference between the intervention group and the control group in the studied components ( P < 0.05). The educational intervention based on the planned behavior theory significantly affected the knowledge, attitude, social norms, and intention for HPV vaccination in women of reproductive age. Therefore, educational intervention recommended as awareness-raising programs and strategies for women. Trial registration: (RCT code: IRCT20220131053891N1). First Registration date: 28/04/2022.

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Cost–Benefit Analysis of Human Papillomavirus Vaccine in Iran

Cited by 3 publications

References 33 publications

Cervical Cancer Prevention, Its Challenges and Solutions in Iran and Worldwide: A Systematic Review

Cervical Cancer Prevention, Its Challenges and Solutions in Iran and Worldwide: A Systematic Review

Using a Dynamic Model to Estimate the Cost-Effectiveness of HPV Vaccination in Iran

The effect of education based on planned behavior theory on women’s knowledge and attitudes about human papillomavirus

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