Cost-Effectiveness Analysis of Romiplostim for The Treatment of Adult Chronic Immune Thrombocytopenic Purpura (Itp) In Brazil

Santos, RF dos; Vargas-Valencia, J; Giannopoulou, Andromachi; Campioni, Marco

doi:10.1016/j.jval.2015.09.2438

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 13 Several studies have assessed the cost of ROMI per patient who responded to treatment. 14 – 16 However, these studies did not consider pediatric patients in a US setting and costs were not compared to the costs for EPAG treatment. One study compared EPAG and ROMI to “watch-and-rescue” (W&R) in a cost per response analysis: the TPO-R agonists proved cost-effective.…”

Section: Introductionmentioning

confidence: 99%

Cost-consequence model comparing eltrombopag and romiplostim in pediatric patients with chronic immune thrombocytopenia

Tremblay¹,

Dolph²,

Bhor³

et al. 2018

CEOR

View full text Add to dashboard Cite

BackgroundImmune thrombocytopenia (ITP) is an auto-immune disorder characterized by enhanced platelet destruction and, subsequently, the potential for increased bleeding. Thrombopoietin receptor (TPO-R) agonists have recently emerged as promising therapies for ITP patients who are refractory to other treatments. While eltrombopag (EPAG) is the only TPO-R agonist US Food and Drug Administration approved for use in pediatric patients, romiplostin (ROMI) has been used in Phase III clinical studies.MethodsA cost-consequence model (CCM) was developed to evaluate the costs of EPAG, ROMI, and watch-and-rescue (W&R) in relation to their respective treatment outcomes in previously-treated pediatric chronic ITP (cITP) over a 26-week time horizon. The costs of drugs, administration, routine care, rescue medications, adverse events, and mortality were included. Data on platelet count response rate, bleeding events, and adverse events were derived from all relevant identified Phase III-registered clinical trials, health outcomes were compared via indirect treatment comparison.ResultsThe overall estimated cost of EPAG per patient was US$66,550, compared to US$101,056 for ROMI and US$32,720 for W&R. EPAG’s lower cost compared to ROMI was largely due to lower drug costs (US$62,202 vs US$84,396), administration costs (US$0 vs US$1,955), and significantly lower costs due to severe bleeding (US$354 vs US$10,191). When assessing cost per severe bleeding event avoided, EPAG was dominant over ROMI (less expensive and more effective). EPAG was again dominant over ROMI when assessing the cost per responder and per bleeding event (any grade). Sensitivity analysis was consistent with the base case findings.ConclusionEPAG was the preferred TPO-R agonist to treat cITP when indirectly compared to ROMI, largely driven by its favorable severe bleeding outcomes and lower drug and administration costs.

show abstract

Section: Introductionmentioning

confidence: 99%