Cost-Effectiveness of Adjuvant Chemotherapy in the Treatment of Early-Stage Colon Cancer

Soni, Amy; Chu, Edward

doi:10.1016/j.clcc.2015.05.002

Cited by 7 publications

(4 citation statements)

References 55 publications

(93 reference statements)

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“…Cost-effectiveness studies are widely conducted in a variety of conditions to assess the use of a specific medication, e.g., the use of fruquintinib in colorectal carcinoma [ 18 ], or the value of an added intervention, e.g., the use of adjuvant therapy in early-stage colon cancer [ 19 ]. However, cost-effectiveness studies focused entirely on CBC are lacking.…”

Section: Discussionmentioning

confidence: 99%

The Cost-Effectiveness of Requesting a Complete Blood Count (CBC) in the Management of COVID-19 in Saudi Arabia

Sayed

2022

Healthcare

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Background: Since the beginning of the COVID-19 pandemic, studies have attempted to determine the value of the different laboratory investigations. This study aims to assess the cost-effectiveness of requesting a complete blood count (CBC) for COVID-19 patients, as opposed to ordering a COVID-19 antibody titer in Saudi Arabia. Methods: The prices of a CBC, COVID-19 PCR, and antibody titer were obtained from 40 healthcare establishments in Saudi Arabia, between January and February 2022. Results: Requesting a CBC is significantly cheaper than requesting a COVID-19 antibody titer, which was available in almost all of the establishments, as compared to COVID-19 PCR and antibody titer testing. The investigation prices did not differ significantly between hospitals and private laboratories, nor across cities in Saudi Arabia. Conclusions: CBC, which provides valuable information on the patient’s condition and prognosis, is a cost-effective and widely available tool for managing COVID-19. The price and availability of CBC warrant it to be included in the COVID-19 management protocols.

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Section: Discussionmentioning

confidence: 99%

The Cost-Effectiveness of Requesting a Complete Blood Count (CBC) in the Management of COVID-19 in Saudi Arabia

Sayed

2022

Healthcare

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“…However, cost effectiveness and quality of life of adjuvant chemotherapy are major concerns in the "real world" [13,14]. Uncertainty remains regarding the optimal treatment of elderly patients and patients with comorbidities [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…For patients received FOLFOLX regimen, another surgery for Port implantation is needed, and some of them need in hospital stay 2 days for continuous 5-Fu infusion. Obviously, oral chemotherapy either capecitabine or tegafur-uracil regimen is superior to FOLFOX in terms of quality of life [13,14].…”

Section: Discussionmentioning

confidence: 99%

“Real World” Effectiveness of Different Postoperative Adjuvant Chemotherapy Regimens in Stage III Colon Cancer Patients

Jm¹,

Hy²,

Sf³

et al. 2016

Chemotherapy

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“…From a study reviewed the outcomes of randomized clinical trials (RCTs) and CEA, capecitabine-based regimens were less costly and more effective than 5-FUbased regimens. The combination of oxaliplatin leads to modestly improved effectiveness and at an acceptable incremental cost (Soni & Chu, 2015) as shown in Table 16.…”

Section: Cost-effectiveness Analysis Of Colorectal Cancer Treatmentmentioning

confidence: 99%

Patient preference and cost-effectiveness analysis of colorectal cancer screening and treatment

Phisalprapa

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Background/Aims: Colorectal cancer (CRC) screening and treatment have been reported to be cost-effective in many high-income countries. However, there was no such study in low- and middle-income countries (LMICs). This study aimed to assess the factors determine individuals' preferences and cost-effectiveness of CRC screening and treatment. Methods: This study consists of three parts. The first part focused on the factors determine individuals' preferences for CRC screening using discrete choice experiment and multinomial logit model. The second part investigated the cost-effectiveness and budget impact analyses of CRC screening comparing between annual fecal immunochemical test (FIT) and colonoscopy every 10 years. The results from the first part can be used to improve patients' participation rate which is the key factor for the cost-effectiveness analysis of the screening tests. Finally, the last part evaluated the cost-effectiveness and budget impact analyses of CRC stage III treatment. This part aimed to identify the most cost-effective treatment regimen in Thailand. The input parameters were obtained from�Siriraj CRC screening and treatment projects, health care costs and databases of Thailand, and systematic literature review. Results: A total of 400 respondents preferred screening with high risk reduction of CRC-related mortality, no complication, 5-year interval, less bowel preparation, and lower cost. FIT is the preferred choice of screening with the highest willingness-to-pay and uptake rate. From cost-effectiveness analysis results, both FIT and colonoscopy were cost-effective when compared to no screening. Colonoscopy was cost-effective when compared to FIT. However, colonoscopy required 8-times higher budget and more human resource than FIT. In addition, for CRC stage III, the new regimens of capecitabine and irinotecan will be cost-effective if the prices were reduced about 50-80%. The budget impact of early screening was lower than treatment due to the preventing of premature deaths. Conclusions: This study provides real-world patients' preference and cost-effectiveness evidence of CRC screening and treatment. Annual FIT was preferred to other screening tests and it could be implemented with no human resource and financial constraint. The new drugs for CRC stage III treatment were not cost-effective. Policy makers can use these findings to improve the success rate of CRC screening and appropriate treatment in Thailand.�

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Cost-Effectiveness of Adjuvant Chemotherapy in the Treatment of Early-Stage Colon Cancer

Cited by 7 publications

References 55 publications

The Cost-Effectiveness of Requesting a Complete Blood Count (CBC) in the Management of COVID-19 in Saudi Arabia

The Cost-Effectiveness of Requesting a Complete Blood Count (CBC) in the Management of COVID-19 in Saudi Arabia

“Real World” Effectiveness of Different Postoperative Adjuvant Chemotherapy Regimens in Stage III Colon Cancer Patients

Patient preference and cost-effectiveness analysis of colorectal cancer screening and treatment

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