Cost-effectiveness of chronic kidney disease mass screening test in Japan

Kondo, Masahide; Yamagata, Kunihiro; Hoshi, Shu Ling; Saito, Chie; Asahi, Koichi; Moriyama, Toshiki; Tsuruya, Kazuhiko; Yoshida, Hiroyuki; Iseki, Kunitoshi; Watanabe, Tsuyoshi

doi:10.1007/s10157-011-0567-1

Cited by 66 publications

(53 citation statements)

References 39 publications

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“…74 Systematic population-based CKD screening should be considered by societies around the world to determine the portion of the population at risk versus those affected by CKD. [75][76][77] Currently, few societies implement systematic screening for adults unless they have risk factors, such as diabetes mellitus or advanced age. 78 Considering that early-to moderate stage CKD is relatively asymptomatic, screening has multiple advantages.…”

Section: Population-level Ckd Screeningmentioning

confidence: 99%

Maintenance Dialysis throughout the World in Years 1990 and 2010

Thomas

Wulf

Bikbov

et al. 2015

Journal of the American Society of Nephrology

174

137

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Rapidly rising global rates of chronic diseases portend a consequent rise in ESRD. Despite this, kidney disease is not included in the list of noncommunicable diseases (NCDs) targeted by the United Nations for 25% reduction by year 2025. In an effort to accurately report the trajectory and pattern of global growth of maintenance dialysis, we present the change in prevalence and incidence from 1990 to 2010. Data were extracted from the Global Burden of Disease 2010 epidemiologic database. The results are on the basis of an analysis of data from worldwide national and regional renal disease registries and detailed systematic literature review for years 1980-2010. Incidence and prevalence estimates of provision of maintenance dialysis from this database were updated using a negative binomial Bayesian metaregression tool for 187 countries. Results indicate substantial growth in utilization of maintenance dialysis in almost all world regions. Changes in population structure, changes in aging, and the worldwide increase in diabetes mellitus and hypertension explain a significant portion, but not all, of the increase because increased dialysis provision also accounts for a portion of the rise. These findings argue for the importance of inclusion of kidney disease among NCD targets for reducing premature death throughout the world.

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Section: Population-level Ckd Screeningmentioning

confidence: 99%

Maintenance Dialysis throughout the World in Years 1990 and 2010

Thomas

Wulf

Bikbov

et al. 2015

Journal of the American Society of Nephrology

174

137

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“…Other studies combine eGFR evaluation with microalbuminuria and/or proteinuria [11,12,13,14]. However, there is some debate whether these full tests are economically viable on a large scale [7,9,15]. CKD screening may be cost effective only in high-risk populations or general populations that have a high prevalence of CKD; otherwise simpler testing might be needed to reduce costs [16,17].…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Use of Urinalysis for Screening Early-Stage Renal Insufficiency

Xue

Zhang

Teng

et al. 2016

Nephron

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Background/Aims: Proteinuria and hematuria detected by routine urinalysis can indicate impaired renal function. This study evaluated the effect of routine urinalysis in screening out patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m² at an early stage and investigated its associated factors. Methods: Healthy adults who underwent physical examination between September 2008 and September 2013 were enrolled in the study (n = 43,516). Urine was analyzed for protein, and red and white blood cells. Ten milliliter blood samples were collected for serum creatinine, urea, albumin and other parameters for the estimation of eGFR and renal function. Results: Abnormal routine urinalysis was found in 7.1% and eGFR <60 ml/min/1.73 m² was found in 0.9% of subjects. Age and gender were similar in the overall and abnormal urinalysis populations (43 vs. 43 years and 36.7 vs. 38.2% females, respectively), but the eGFR <60 ml/min/1.73 m² group were older (64 years, p < 0.001) with increased females (46.4%, p = 0.002). Sensitivity for predicting eGFR <60 ml/min/1.73 m² was 0.110 and specificity was 0.928. Univariate and multivariate analyses in 6,318 subjects with more detailed clinical data suggested significant associations of sex (OR 0.058, 95% CI 0.030-0.113), age (OR 1.045, 95% CI 1.027-1.064), and high density lipoprotein (HDL) (OR 0.158, 95% CI 0.043-0.587) with eGFR <60 ml/min/1.73 m². Conclusion: Routine urinalysis showed a poor performance in the screening for early-stage renal insufficiency. In future, other screening methods should be considered. Age, gender and HDL were associated with eGFR <60 ml/min/1.73 m².

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“…Results of previous studies showed that use of dipstick urinalysis to detect proteinuria but was inadequate in the routine screening for the detection of early stage CKD due to insufficient sensitivity and specificity (6). In the general population, screening combined with serum concentrations of creatinine or other biomarkers is therefore likely to be appropriate and cost-effective for the stratification of high-risk individuals (7). Identification of genetic variants that confer susceptibility to CKD may thus be important in determining which patients are recommended for frequent checkup.…”

Section: Introductionmentioning

confidence: 99%

Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals

Oguri¹,

Fujimaki

Horibe

et al. 2013

Biomedical Reports

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Abstract.Results of recent studies have shown that the C→T polymorphism (rs6929846) of the butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction. The aim of the current study was to examine the association of rs6929846 of BTN2A1 with chronic kidney disease (CKD) in community-dwelling individuals. Study subjects comprised 1,709 community-dwelling individuals, including 435 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m 2 ] and 1,274 controls (eGFR≥90 ml/min per 1.73 m 2 ) who were recruited to a population-based cohort study. Genotype distributions (P=0.0010) and allele frequencies (P=0.0002) of rs6929846 were significantly associated with CKD. Multivariate logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (P=0.0002; odds ratio, 2.02; dominant model) associated with CKD, with the minor T allele representing a risk for this condition. The serum concentrations of creatinine were significantly (P= 0.0107) higher for all the individuals, whereas eGFR was significantly (P=0.0468) lower for individuals in the combined group of CT and TT genotypes compared to those with the CC genotype. BTN2A1 may therefore be a susceptibility gene for CKD.

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Cost-effectiveness of chronic kidney disease mass screening test in Japan

Cited by 66 publications

References 39 publications

Maintenance Dialysis throughout the World in Years 1990 and 2010

Maintenance Dialysis throughout the World in Years 1990 and 2010

A Cross-Sectional Study on the Use of Urinalysis for Screening Early-Stage Renal Insufficiency

Association of a polymorphism of BTN2A1 with chronic kidney disease in community-dwelling individuals

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