Cost-Effectiveness of Platelet Glycoprotein IIb/IIIa Inhibition With Eptifibatide in Patients With Non–ST-Elevation Acute Coronary Syndromes

Mark, Daniel B.; Harrington, Robert A.; Lincoff, A. Michael; Califf, Robert M.; Nelson, Charlotte L.; Tsiatis, Anastasios A.; Buell, Hope; Mahaffey, Kenneth W.; Davidson‐Ray, Linda; Topol, Eric J.

doi:10.1161/01.cir.101.4.366

Cited by 102 publications

(88 citation statements)

References 6 publications

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“…These two exceptions isolated one country from the trial and estimated costs, effects and cost-effectiveness solely using patient data from that country. 194,195 Sensitivity analysis Table 12 describes the different sensitivity analysis approaches used in the studies included in the present review. Details of those variables, which have the potential to vary by location, which were assessed in these analysis are also provided.…”

Section: Table 11 Details Of the Basis Of The Cost Analysis In Econommentioning

confidence: 99%

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Generalisability in economic evaluation studies in healthcare: a review and case studies

Sculpher

Fs²,

Manca³

et al. 2004

Health Technol Assess

320

297

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK.We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS, the public,...

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Section: Table 11 Details Of the Basis Of The Cost Analysis In Econommentioning

confidence: 99%

“…First, only two studies 194,195 assessed the representativeness of the study sample to the study population in the trial centres. If only a small proportion of patients are recruited into trials from amongst those eligible (i.e.…”

Section: Study Reportingmentioning

confidence: 99%

Generalisability in economic evaluation studies in healthcare: a review and case studies

Sculpher

Fs²,

Manca³

et al. 2004

Health Technol Assess

320

297

View full text Add to dashboard Cite

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“…The study design proposed in our application involved 3 major components: (1) collection of empirical resource use data (all patients) and hospital cost data (US patients), (2) an intention-to-treat comparison of within-study medical costs, and (3) a lifetime cost-effectiveness analysis. The cost-effectiveness analysis used empirically collected study data to make projections of lifetime costs and life expectancy beyond the end of study follow-up.…”

Section: Overview Of Economic Analysesmentioning

confidence: 99%

Cost-Effectiveness of Defibrillator Therapy or Amiodarone in Chronic Stable Heart Failure

et al. 2006

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cardioverter-defibrillator (ICD) therapy significantly reduced all-cause mortality rates compared with medical therapy alone in patients with stable, moderately symptomatic heart failure, whereas amiodarone had no benefit on mortality rates. We examined long-term economic implications of these results. Methods and Results-Medical costs were estimated by using hospital billing data and the Medicare Fee Schedule. Our base case cost-effectiveness analysis used empirical clinical and cost data to estimate the lifetime incremental cost of saving an extra life-year with ICD therapy relative to medical therapy alone. At 5 years, the amiodarone arm had a survival rate equivalent to that of the placebo arm and higher costs than the placebo arm. For ICD relative to medical therapy alone, the base case lifetime cost-effectiveness and cost-utility ratios (discounted at 3%) were $38 389 per life-year saved (LYS) and $41 530 per quality-adjusted LYS, respectively. A cost-effectiveness ratio Ͻ$100 000 was obtained in 99% of 1000 bootstrap repetitions. The cost-effectiveness ratio was sensitive to the amount of extrapolation beyond the empirical 5-year trial

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“…The effectiveness of eptifibatide was based on all Western European patients: a 0.37% risk difference for survival and a 1.01% risk difference for MI-free survival at 6 months favouring eptifibatide. Using the modelling approach and life expectancy data detailed in a US paper using similar methods, 98 LYG were estimated. Using cost data from UK patients, the cost-effectiveness analysis showed that treatment with eptifibatide was dominant.…”

Section: Comparison With the Results Of Other Studiesmentioning

confidence: 99%

Cost-effectiveness of alternative strategies for the initial medical management of non-ST elevation acute coronary syndrome: systematic review and decision-analytical modelling

Robinson

Palmer²,

Sculpher³

et al. 2005

Health Technol Assess

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined to include all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care, rather than settings of care.The HTA Programme commissions research only on topics where it has identified key gaps in the evidence needed by the NHS. Suggestions for topics are actively sought from people working in the NHS,...

show abstract

Cost-Effectiveness of Platelet Glycoprotein IIb/IIIa Inhibition With Eptifibatide in Patients With Non–ST-Elevation Acute Coronary Syndromes

Cited by 102 publications

References 6 publications

Generalisability in economic evaluation studies in healthcare: a review and case studies

Generalisability in economic evaluation studies in healthcare: a review and case studies

Cost-Effectiveness of Defibrillator Therapy or Amiodarone in Chronic Stable Heart Failure

Cost-effectiveness of alternative strategies for the initial medical management of non-ST elevation acute coronary syndrome: systematic review and decision-analytical modelling

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