Cost Effectiveness of Quetiapine in Patients with Acute Bipolar Depression and in Maintenance Treatment after an Acute Depressive Episode

Ekman, Mattias; Lindgren, Peter; Miltenburger, Carolin; Meier, Genevieve; Locklear, Julie; Chatterton, Mary Lou

doi:10.2165/11594930-000000000-00000

Cited by 19 publications

(70 citation statements)

References 55 publications

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“… satisfied the lowest number of quality criteria (49%), the DES model developed by Ekman et al. fulfilled the highest proportion (94%).…”

Section: Resultsmentioning

confidence: 98%

“…All of the modeling studies in our review had a clear definition of the decision problem, model objectives, and scope. Different modeling approaches were used to address the study question, including one decision tree model , eight cohort‐based Markov models , two DES studies , two publications using the same mathematical model , and two studies that failed to explicitly state their approach or structure . All studies except Klok et al.…”

Section: Resultsmentioning

confidence: 99%

“… specified the primary decision maker and perspective of the study. Nine studies adopted a health care provider perspective , three studies utilized a third‐party payer perspective , one study adopted a societal perspective , and two studies reported results using both third‐party payer and societal perspectives . Six of the modeling studies (40%) compared two alternative treatments; two compared four alternatives, while seven studies (47%) compared more than five alternatives.…”

Section: Resultsmentioning

confidence: 99%

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Economic evaluations in bipolar disorder: a systematic review and critical appraisal

et al. 2014

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The cost-effectiveness of different treatment strategies varied between settings, and transferability of these results across settings remains questionable. Although additional research using a longer time horizon is required to validate the findings for trial-based economic evaluations, discrete event simulation appears to be the most natural and plausible technique for modeling the cost-effectiveness of alternative BD treatment strategies.

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“… satisfied the lowest number of quality criteria (49%), the DES model developed by Ekman et al. fulfilled the highest proportion (94%).…”

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Economic evaluations in bipolar disorder: a systematic review and critical appraisal

et al. 2014

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“…Probabilities of discontinuation and relapse to manic, mixed, and depressive episodes were sourced from published meta-analyses [29, 30]. …”

Section: Methodsmentioning

confidence: 99%

“…As in the UK model, probability of discontinuing treatment with the initial drug during periods of disease stability was calculated by applying a risk ratio from a published meta-analysis of clinical trials [34] to an underlying baseline probability of discontinuing on placebo. The placebo discontinuation rates are based on a published discrete-event simulation model for patients with acute bipolar depression [29]. Again, as ASE-treatment discontinuation risk was not available in the meta-analysis, it was assumed that the treatment discontinuation probability for ASE was the same as for OLA (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Cost-Effectiveness of Asenapine in the Treatment of Patients with Bipolar I Disorder with Mixed Episodes in an Italian Context

Caresano

Sciascio²,

Fagiolini

et al. 2014

Adv Ther

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IntroductionBipolar disorder is a chronic disease characterized by periods of mania or hypomania, depression, or a combination of both (mixed state). Because bipolar disorder is one of the leading causes of disability, it represents an important economic burden on society. Asenapine (ASE) is a new second-generation antipsychotic developed and approved for the treatment of manic or mixed episodes associated with bipolar disorder. The objective of the present study was to assess the cost-effectiveness of ASE compared to olanzapine (OLA) in the treatment of patients experiencing mixed episodes associated with bipolar I disorder in the context of the Italian National Health Service (NHS).MethodsA pharmacoeconomic model was developed to simulate the management of Italian bipolar I patients with mixed episodes over a 5-year time horizon by combining clinical parameters with resource utilization. An expert panel of Italian psychiatrists and health economists was responsible for adapting a UK model to the Italian context. The primary outcome measure of the economic evaluation was the incremental cost effectiveness ratio, where effectiveness is measured in terms of quality adjusted life-years gained. Scenario analyses, sensitivity analyses, and a probabilistic sensitivity analysis were performed to test the robustness of the model.ResultsThis pharmacoeconomic model showed that ASE resulted to be dominant over OLA; in fact, ASE was associated with lower direct costs (derived largely by the savings from hospitalizations avoided) and also generated a better quality of life. Results were robust to changes in key parameters; both scenario analyses and sensitivity analyses demonstrated model reliability.ConclusionsResults from this study suggest that the management of bipolar I patients with mixed episodes using ASE as alternative to OLA can lead to cost saving for the Italian NHS and improve patients quality of life.Electronic supplementary materialThe online version of this article (doi:10.1007/s12325-014-0139-3) contains supplementary material, which is available to authorized users.

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Cost-Effectiveness of Treatment for Bipolar Disorders

Lima

Cruz

Cohen

et al. 2017

Mental Health Economics

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Cost Effectiveness of Quetiapine in Patients with Acute Bipolar Depression and in Maintenance Treatment after an Acute Depressive Episode

Abstract: Compared with olanzapine, the results suggest that quetiapine is cost effective as a maintenance treatment for bipolar depression.

Cited by 19 publications

References 55 publications

Economic evaluations in bipolar disorder: a systematic review and critical appraisal

Economic evaluations in bipolar disorder: a systematic review and critical appraisal

Cost-Effectiveness of Asenapine in the Treatment of Patients with Bipolar I Disorder with Mixed Episodes in an Italian Context

Cost-Effectiveness of Treatment for Bipolar Disorders

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