Cost-Effectiveness of Recombinant Activated Factor VII as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients in Germany

Rossaint, Rolf; Christensen, Michael Cronquist; Choong, Philip Iau Tsau; Boffard, Kenneth D.; Riou, Bruno; Rizoli, Sandro; Kluger, Yoram; Lefering, Rolf; Morris, Stephen

doi:10.1007/s00068-007-6210-x

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…Figure 2 shows that 21 studies (60.0%) evaluated health care programs such as disease management programs which were assessed in 8 studies (22.9%) alone [ 21 , 25 – 27 , 37 , 39 , 43 , 49 ]. Evaluations were also performed on pharmaceuticals in 8 studies (22.8%) [ 30 , 35 , 41 , 44 – 48 ] and medical products or procedures in 6 studies (17.1%) [ 2 , 3 , 23 , 24 , 36 , 50 ]. Funding can mainly be ascribed to industry ( n = 15, 42.9%) – generally the involved health insurance fund or product manufacturer – or public sources ( n = 8, 22.9%).…”

Section: Resultsmentioning

confidence: 99%

“…With regard to the study design of the identified economic evaluations, no study used monetary values to measure effects and can therefore be classified as a cost-benefit analysis. Two studies (5.7%) measured health benefits in quality-adjusted life years (QALY) as well as life years gained and are categorized here as cost-utility analysis [ 41 , 44 ]. A total of 13 studies (37.1%) are cost-effectiveness analysis as they measured consequences in natural units such as life years gained [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…Finally, two studies (5.7%) did not specify which individual fund supplied the data [ 34 , 37 ]. Of the five studies (14.3%) not based on insurance data, three studies (8.6%) obtained hospital data [ 23 , 48 , 50 ], one study (2.9%) used the German Trauma Registry [ 41 ], and one study (2.9%) referenced the International Marketing Services Health (IMS) database as a source [ 44 ]. Detailed information on study characteristics can be found in Additional file 1 .…”

Section: Resultsmentioning

confidence: 99%

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Health economic evaluations based on routine data in Germany: a systematic review

Gansen

2018

BMC Health Serv Res

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BackgroundImproved data access and funding for health services research have promoted the application of routine data to measure costs and effects of interventions within the German health care system. Following the trend towards real world evidence, this review aims to evaluate the status and quality of health economic evaluations based on routine data in Germany.MethodsTo identify relevant economic evaluations, a systematic literature search in the databases PubMed and EMBASE was complemented by a manual search. The included studies had to be full economic evaluations using German routine data to measure either costs, effects, or both. Study characteristics were assessed with a structured template. Additionally, the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) were used to measure quality of reporting.ResultsIn total, 912 records were identified and 35 studies were included in the further analysis. The majority of these studies was published in the past 5 years (n = 27, 77.1%) and used insurance claims data as a source of routine data (n = 30, 85.7%). The most common method used for handling selection bias was propensity score matching. With regard to the reporting quality, 42.9% (n = 15) of the studies satisfied at least 80% of the criteria on the CHEERS checklist.ConclusionsThis review confirms that routine data has become an increasingly common data source for health economic evaluations in Germany. While most studies addressed the application of routine data, this analysis reveals deficits in considering methodological particularities and in reporting quality of economic evaluations based on routine data. Nevertheless, this review demonstrates the overall potential of routine data for economic evaluations.Electronic supplementary materialThe online version of this article (10.1186/s12913-018-3080-3) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Health economic evaluations based on routine data in Germany: a systematic review

Gansen

2018

BMC Health Serv Res

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“…13 It is commonly used in cost effectiveness analyses to calculate qualityadjusted life years 14 and consists of five dimensions that assess mobility, self-care, usual activities, pain, and anxiety or depression. Each dimension is scored based on three levels of severity (no problems, moderate problems, and extreme problems).…”

Section: Hrqol Assessmentmentioning

confidence: 99%

Quality of Life After Severe Trauma: Results From the Global Trauma Trial With Recombinant Factor VII

Christensen

Banner

Lefering

et al. 2011

Journal of Trauma: Injury, Infection &Amp; Critical Care

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Three months after severe trauma injury, survivors report very poor HRQOL. Physical wellbeing is generally more negatively affected than mental wellbeing. A trauma-specific HRQOL instrument reveals more diverse mental health problems than generic instruments. In a global trauma population, postinjury HRQOL is predicted by demographic and socioeconomic characteristics, type of injury, and treatment received.

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“…The most commonly applied instruments were the SF-36 and EQ-5D; both are so-called generic instruments, suitable for assessing HRQoL in a broad range of patient populations. Of these instruments, the validity is well recognized [102][103][104][105][106][107], leading to extensive use in trauma populations for baseline and follow up assessment of HRQoL; available country specific population norms for all subscales make meaningful comparisons possible. The TOP, QOLIBRI, HASPOC, T-QoL and St. George's Respiratory Questionnaire were the only disease-specific instruments that were used in the included articles, the first four assessing specifically the impact of trauma on HRQoL.…”

Section: Summary Of Main Resultsmentioning

confidence: 99%

Health-related quality of life after severe trauma and available PROMS: an updated review (part I)

Lotfalla

Halm

Schepers

et al. 2022

Eur J Trauma Emerg Surg

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Introduction Throughout the years, a decreasing trend in mortality rate has been demonstrated in patients suffering severe trauma. This increases the relevance of documentation of other outcomes for this population, including patient-reported outcome measures (PROMs), such as health-related quality of life (HRQoL). The aim of this review was to summarize the results of the studies that have been conducted regarding HRQoL in severely injured patients (as defined by the articles’ authors). Also, we present the instruments that are used most frequently to assess HRQoL in patients suffering severe trauma. Methods A literature search was conducted in the Cochrane Library, EMBASE, PubMed, and Web of Science for articles published from inception until the 1st of January 2022. Reference lists of included articles were reviewed as well. Studies were considered eligible when a population of patients with major, multiple or severe injury and/or polytrauma was included, well-defined by means of an ISS-threshold, and the outcome of interest was described in terms of (HR)QoL. A narrative design was chosen for this review. Results The search strategy identified 1583 articles, which were reduced to 113 after application of the eligibility criteria. In total, nineteen instruments were used to assess HRQoL. The SF-36 was used most frequently, followed by the EQ-5D and SF-12. HRQoL in patients with severe trauma was often compared to normative population norms or pre-injury status, and was found to be reduced in both cases, regardless of the tool used to assess this outcome. Some studies demonstrated higher scoring of the patients over time, suggesting improved HRQoL after considerable time after severe trauma. Conclusion HRQoL in severely injured patients is overall reduced, regardless of the instrument used to assess it. The instruments that were used most frequently to assess HRQoL were the SF-36 and EQ-5D. Future research is needed to shed light on the consequences of the reduced HRQoL in this population. We recommend routine assessment and documentation of HRQoL in severely injured patients.

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Cost-Effectiveness of Recombinant Activated Factor VII as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients in Germany

Abstract: Based on preliminary evidence from a phase II trial, we conclude that, relative to placebo, rFVIIa may be a cost-effective therapy from the thirdparty payer perspective in Germany.

Cited by 4 publications

References 29 publications

Health economic evaluations based on routine data in Germany: a systematic review

Health economic evaluations based on routine data in Germany: a systematic review

Quality of Life After Severe Trauma: Results From the Global Trauma Trial With Recombinant Factor VII

Health-related quality of life after severe trauma and available PROMS: an updated review (part I)

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