2010
DOI: 10.1242/jcs.064709
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Costars, aDictyosteliumprotein similar to the C-terminal domain of STARS, regulates the actin cytoskeleton and motility

Abstract: SummaryThrough analysis of a chemotaxis mutant obtained from a genetic screen in Dictyostelium discoideum, we have identified a new gene involved in regulating cell migration and have named it costars (cosA). The 82 amino acid Costars protein sequence appears highly conserved among diverse species, and significantly resembles the C-terminal region of the striated muscle activator of Rho signaling (STARS), a mammalian protein that regulates the serum response factor transcriptional activity through actin bindin… Show more

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Cited by 16 publications
(13 citation statements)
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“…Our functional results are only partly in agreement with published data. The highly conserved C‐terminal domain, termed ABD2, residues 294–375, is part of the previously identified actin binding region ranging from residue 234 to residue 3759 and is highly similar to the recently identified protein COSTARS that is also able to bind weakly to F‐actin 26. It is surprising, though that deletion of each of the two binding sites identified here led to a complete loss of actin binding affinity in a previous work 9.…”
Section: Discussionsupporting
confidence: 61%
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“…Our functional results are only partly in agreement with published data. The highly conserved C‐terminal domain, termed ABD2, residues 294–375, is part of the previously identified actin binding region ranging from residue 234 to residue 3759 and is highly similar to the recently identified protein COSTARS that is also able to bind weakly to F‐actin 26. It is surprising, though that deletion of each of the two binding sites identified here led to a complete loss of actin binding affinity in a previous work 9.…”
Section: Discussionsupporting
confidence: 61%
“…It is clear from our results that ABD1 should be able to provide sufficient affinity to bind full‐length MS1 such that it can fulfill its role in the proposed actin cycling mechanism 9, 12. The observation that COSTARS is localized but not necessarily along thin filaments26 and that the C‐terminus of MS1 also binds to other proteins such as ABLIM‐1 and ‐216 would suggest that it might be responsible for other functions. This could be related to the observation of MS1 in the M‐line9 or the nucleus,9, 13, 14 each of which would require specific interactions of MS1.…”
Section: Discussionmentioning
confidence: 68%
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“…SOLiD-SAGE tags were identified for most of the plant genes reported in the previous two studies to be differentially expressed in the tall fescue- N. coenophialum symbiosis. However, only 1 gene, identified as from a costars family gene [40] and corresponding to TFF17 in the previous study [16], was found to have statistically significant differential expression (up-regulated) in S1139RC. The differences between this study and the previous studies may be due to the different species used as well as the different approaches for identification of differentially expressed genes.…”
Section: Resultsmentioning
confidence: 70%
“…To uncover novel molecular players in the pathways underlying chemotactic cell migration, we previously performed a screen for Dictyostelium mutants defective in chemotactic responses to cAMP ( Pang et al. , 2010 ).…”
Section: Introductionmentioning
confidence: 99%