Costo Utilidad de Colágena Polivinil-Pirrolidona en el Tratamiento de Osteartrosis de Rodilla en México

Burbano-Levy, X.; Cardona, Diana; Act, Elsa Palacios; Rico-Alba, Israel; Qf, León Zapata

doi:10.1016/j.vhri.2014.06.006

Cited by 2 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result is in agreement with the low incidence of AEs attributable to IA therapies reported in clinical trials in knee OA, with the main AEs being postinjection pain and swelling, as in our study [ 38 ]. Moreover, we previously reported that polymerized-type I collagen was a dominant cost-benefit alternative compared with NSAIDs in the treatment of symptomatic knee OA [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study

Borja-Flores¹,

Macías‐Hernández

Hernández-Molina

et al. 2020

Advances in Orthopedics

View full text Add to dashboard Cite

Objective. Polymerized-type I collagen (polymerized-collagen) is a downregulator of inflammation and a tissue regenerator. The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. Patients and Methods. This was a cohort study of 309 patients with knee OA. Patients with mild-to-moderate disease were treated weekly with IAIs of 2 mL of polymerized-collagen for six weeks (n = 309). Follow-up was for 6–60 months. The primary endpoints included the following determinations: (1) therapeutic effect; (2) survival from total knee replacement surgery (TKR); (3) Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and pain (visual analogue scale, VAS). Clinical improvement was defined as a decrease in pain exceeding 20 mm on the VAS and the achievement of at least 20% improvement from baseline with respect to the WOMAC score. Radiographic analysis was performed at baseline and 60 months. The joint space width in the medial, lateral, and patellofemoral compartments was calculated. Results. Patients who received IAIs of polymerized-collagen had a statistically significant improvement in the primary criteria (p<0.05). Kaplan–Meier survival analysis of the therapeutic effect demonstrated 98.8% survival at 60 months with TKR as the endpoint. There was no significant reduction in joint space in any compartment based on the analyzed radiographs. No serious adverse events were recorded. Conclusion. Polymerized-collagen increased the time to TKR by at least 60 months, modifying the disease course, improving functional disability, and decreasing pain.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study

Borja-Flores¹,

Macías‐Hernández

Hernández-Molina

et al. 2020

Advances in Orthopedics

View full text Add to dashboard Cite

show abstract

Clasificación de estados de salud y metodologías de valoración de preferencias para el cálculo de AVAC: una revisión de literatura

Acuña

2020

Ens. Econ.

View full text Add to dashboard Cite

Este trabajo tiene por objetivo identificar los principales instrumentos de medición de estados de salud y las metodologías de valoración de preferencias que se utilizan para calcular los años de vida ajustados por calidad —AVAC—. A partir de una revisión de literatura con una estrategia de búsqueda equilibrada para la identificación de referencias bibliográficas relevantes, se presentan las características técnicas de los sistemas de clasificación en salud, como lo son los conceptos funcionales —sociales, mentales, físicos y sensoriales—, la combinación de atributos, el número de estados de salud diferentes, la duración de la encuesta y su administración. Asimismo, referente a las metodologías de valoración de preferencias, se resumen las particularidades sobre la consistencia con la teoría de los AVAC, la flexibilidad en la descripción de estados de salud, los estados peores que la muerte, entre otros aspectos. Se concluye que no existe un sistema de clasificación de estados de salud o método de valoración de preferencias mejor que otro, por lo que el investigador debe elegir la herramienta que mejor se adapte a la condición bajo análisis y al diseño de estudio en específico.

show abstract

Costo Utilidad de Colágena Polivinil-Pirrolidona en el Tratamiento de Osteartrosis de Rodilla en México

Abstract: This is the first economic evaluation of a new medication developed in Mexico and conducted partially with local data. The results of this study allow concluding that collagen-PVP is deemed as the dominant alternative compared with NSAIDs in the treatment of knee osteoarthritis.

Cited by 2 publications

References 23 publications

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study

Clasificación de estados de salud y metodologías de valoración de preferencias para el cálculo de AVAC: una revisión de literatura

Contact Info

Product

Resources

About