“…Activation of nAChRs promotes the expression of synaptic proteins in the brain and enhances cognition in animal models (Buccafusco & Terry, ; Terry et al ., , ; McKay et al ., ; Grizzell et al ., ). For example, cotinine treatment restored impaired memory in mouse and monkey models of impaired hippocampal function (Echeverria et al ., ; Terry et al ., ; Gao et al ., ; Grizzell et al ., ; Patel et al ., ), ameliorated impaired cognition in mouse models of Alzheimer's disease, including working memory (Echeverria et al ., ; Patel et al ., ), memory deficits in animal models of schizophrenia (Buccafusco & Terry, ; Buccafusco et al ., ; Terry et al ., ) and stress‐related memory impairments (Zeitlin et al ., ; Grizzell et al ., ).…”