An exact model for a single-electron transistor was developed within the circuit simulation package SPICE. This model uses the orthodox theory of single-electron tunneling and determines the average current through the transistor as a function of the bias voltage, the gate voltage, and the temperature. Circuits including single-electron transistors, field-effect transistors (FETs), and operational amplifiers were then simulated. In these circuits, the single-electron transistors provide the charge sensitivity while the FETs tune the background charges, provide gain, and provide low output impedance.