Cough in Allergic Rhinitis

Abstract

Allergic Rhinitis 82 study and to define them separately quite difficult. By gross dividing, however, these physiological and morphological attributes can be used to identify at least three broad classes of afferent nerve fibers: rapidly adapting mechanoreceptors (RARs), slowly adapting mechanoreceptors (SARs) and unmyelinated C-fibers (C-fibers) (Mazzone et al., 2003). 2.1.1 Rapidly adapting receptors (RARs) While the anatomical arrangement of RARs termination is unknown, functional studies suggest that these receptors terminate within or beneath the epithelium and are localized to both intra-and extrapulmonary airways (Bergren & Sampson, 1982; Riccio et al., 1996c, Ho et al., 2001). RARs, as its name implies, is differentiated from the other airway afferent nerves by their rapid (1-2sec) adaptation to sustained lung inflations (

Relationship between rhinitis and nocturnal cough in school children

“…In particular, histamine applied into the nose caused sensitization of the cough reflex in healthy subjects (13). The cough sensitivity of patients with allergic rhinitis was higher than that of healthy subjects and was further increased among patients with pollen allergy during the pollen season compared with out‐of‐pollen season (14). Our findings show that children whose nasal symptoms more severely impaired their daily activities had a significantly higher prevalence of nocturnal cough.…”

Chronic cough in subjects with upper airway diseases - analysis of mechanisms and clinical applications

“…Cough reflex was sensitized in subjects with allergic rhinitis particularly during the pollen season [24]. Cough threshold in subjects with rhinitis measured by C2 and C5 parameters was significantly lower comparing to healthy volunteers [25].…”

“…Most published data suggest that nasal sensory nerves are involved in sensitization and 'up-regulation' of the cough by nasal inflammation and trigeminal afferent stimulation [18, 19, 22, 24]. In contrast to other sites-such as mouth, pharynx, respiratory tract and lungs, cerebral cortex and somatic tissues, or hypercapnia and/or hypoxia, that may down-regulate cough center [49], little evidence is available to support desensitization of cough from the nose.…”

Workshop: Tuning the ‘cough center’

“…We next evaluated sensitization of the cough reflex inpatients with allergic rhinitis but without nasal histamine. We found that the cough reflex was more sensitive in patients with allergic rhinitis compared with healthy subjects [26]. …”