Cough reflex in allergic dogs

House, Aileen; Celly, Chander; Skeans, Susan; Lamca, James; Egan, Robert W.; Hey, John A.; Chapman, Richard W.

doi:10.1016/j.ejphar.2004.03.053

Cited by 23 publications

(18 citation statements)

References 30 publications

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“…The cough response consisted of an increase in cough number (number of coughs per stimulus trial) and a transient decrease in oesophageal pressure in the first few minutes post challenge. This pattern was very similar to that produced by challenge with inhaled histamine [24]. Furthermore, the decrease in oesophageal pressure during cough may be due to the increased airways resistance and decreased dynamic compliance that occurred after antigen challenge in this model [24].…”

Section: Allergic Animalssupporting

confidence: 73%

“…This pattern was very similar to that produced by challenge with inhaled histamine [24]. Furthermore, the decrease in oesophageal pressure during cough may be due to the increased airways resistance and decreased dynamic compliance that occurred after antigen challenge in this model [24]. Antigen exposure did not elicit spontaneous cough in this preparation and mechanical stimulation of the trachea did not produce enhanced cough in animals that were sensitized but not challenged.…”

Section: Allergic Animalssupporting

confidence: 71%

“…Anaesthetized dogs sensitized and acutely challenged with aerosol ragweed antigen had an enhanced cough response to mechanical stimulation of the trachea [24]. The cough response consisted of an increase in cough number (number of coughs per stimulus trial) and a transient decrease in oesophageal pressure in the first few minutes post challenge.…”

Section: Allergic Animalsmentioning

confidence: 99%

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Experimental models and mechanisms of enhanced coughing

Bolser

2004

Pulmonary Pharmacology & Therapeutics

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Enhanced coughing can be produced in a variety of animal models, including the guinea pig, cat, dog and pig. Typically, airway inflammation has been produced by sensitization, exposure to cigarette smoke, sulphur dioxide or angiotensin-converting enzyme inhibitors. In some of these models, inflammatory mediators such as bradykinin and tachykinins have been shown to contribute to the enhanced coughing. While most of these studies have focussed on peripheral mechanisms, increases in central excitability of the cough reflex have been shown to occur as a result of airway inflammation. As such, we propose that enhanced coughing in pathological conditions is the result of plastic changes in both peripheral and central neural elements. Furthermore, we present a modified model of the neurogenesis of cough that takes into account peripheral and central plasticity induced by mediators of inflammation.

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Section: Allergic Animalssupporting

confidence: 73%

Section: Allergic Animalssupporting

confidence: 71%

Section: Allergic Animalsmentioning

confidence: 99%

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Experimental models and mechanisms of enhanced coughing

Bolser

2004

Pulmonary Pharmacology & Therapeutics

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“…Tachykinins appear to play a role in the augmented cough response in allergic guinea pigs, since enhanced cough response to capsaicin, following antigen challenge, has been shown to be suppressed by neurokinin (NK) 1 and NK 2 and dual (NK 1 /NK 2 ) receptor antagonists [141]. An enhanced cough response to mechanical stimulation of the trachea has also been seen in anaesthetised dogs sensitised and challenged with ragweed antigen [143].…”

Section: Allergic Modelsmentioning

confidence: 79%

ERS guidelines on the assessment of cough

Morice¹,

Fontana²,

Belvisi³

et al. 2007

Eur Respir J

612

619

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“…Changes in threshold sensitivity or on the number of doses evoking repetitive coughing events may be a more appropriate analysis rather than the cumulative number of coughs over a complete challenge [53]. A similar approach has been employed in studying cough evoked by mechanical stimulation of the airway mucosa in allergic dogs [80]. …”

Section: Introductionmentioning

confidence: 99%

An update and systematic review on drug therapies for the treatment of refractory chronic cough

Ryan

Vertigan

Birring

2018

Expert Opinion on Pharmacotherapy

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Introduction: Chronic Cough (CC) is common and often associated with significant comorbidity and decreased quality of life. In up to 50% of cases, the cough is refractory despite extensive investigation and treatment trials. It is likely that the key abnormality in refractory CC is dysfunctional, hypersensitive sensory nerves, similar to conditions such as laryngeal hypersensitivity and neuropathic pain.Areas covered: The aim of this systematic review is to assess drug therapies for refractory CC. The authors review the current management of CC and provide discussion of the similarities between neuropathic pain and refractory CC. They review repurposed and new pharmacological treatments. Several meta-analyses were performed to compare the efficacy of treatments where possible.Expert opinion: Repurposed pain medications such as gabapentin and pregabalin reduce the frequency of cough and improve quality of life. Along with speech pathology, they are important and alternate treatments for refractory CC. However, more treatments are needed and the P2X3 ion channel receptor antagonists show the most promise. With a better understanding of neuronal activation and sensitisation and their signal processing in the brain, improved animal models of cough, and the use of validated cough measurement tools, more effective treatments will develop.

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Cough reflex in allergic dogs

Cited by 23 publications

References 30 publications

Experimental models and mechanisms of enhanced coughing

Experimental models and mechanisms of enhanced coughing

ERS guidelines on the assessment of cough

An update and systematic review on drug therapies for the treatment of refractory chronic cough

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