ERS guidelines on the assessment of cough

Morice, Alyn H.; Fontana, Giovanni; Belvisi, Maria G.; Birring, Surinder S.; Chung, Kian Fan; Dicpinigaitis, Peter V.; Kastelik, Jack A.; McGarvey, Lorcan; Smith, Jaclyn A.; Tatár, M.; Widdicombe, J. G.

doi:10.1183/09031936.00101006

Cited by 613 publications

(671 citation statements)

References 147 publications

(242 reference statements)

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“…The testing of cough sensitivity with capsaicin inhalation is otherwise often performed with a "single-breath" technique using increasing concentrations of capsaicin until the individual coughs, for example, two or five times (C2 or C5), which has shown a good reproducibility [41,42]. Others, who used both techniques, found that the tidal breathing method with a fixed time and concentration showed good reproducibility and dose-response relationship in the short term, as well as in the long term [8,43].…”

Section: Discussionmentioning

confidence: 99%

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Millqvist

Ternesten-Hasséus

Bende

2008

Pulmonary Pharmacology & Therapeutics

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To cite this version:Eva Millqvist, Ewa Ternesten-Hasséus, Mats Bende. Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity. Pulmonary Pharmacology & Therapeutics, 2008, 21 (5) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d m a n u s c r i p t 4

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Section: Discussionmentioning

confidence: 99%

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Millqvist

Ternesten-Hasséus

Bende

2008

Pulmonary Pharmacology & Therapeutics

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“…Most of the information concerning the likely receptors (nociceptors) involved in cough (physiological and pathological) has come from work with capsaicin (8-methyl-n-vanillyl-6-nomamide), the chemical extract from hot chilli peppers which readily evokes cough in humans and animals [34,35][36]. Capsaicin is believed to activate the transient receptor potential vanilloid 1 (TRPV1) channel which is one of the transient receptor potential (TRP) family of ion channels.…”

Section: Airway Cough Receptorsmentioning

confidence: 99%

Are there clinical features of a sensitized cough reflex?

McGarvey

McKeagney²,

Polley

et al. 2009

Pulmonary Pharmacology & Therapeutics

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Key words: sensory hyperresponsiveness, hyperreactivity, cough reflex, receptor AbstractCough reflex hypersensitization is a key feature in patients with troublesome cough. The clinical consequence of this hypersensitive state is typified by bouts of coughing often triggered by low threshold stimuli encountered by the patient during normal daily activities including exposure to aerosols, scents and odours, a change in air temperature and when talking or laughing. These features are often perceived by cough patients to be the most disruptive aspect of their condition and undoubtedly contribute to impaired quality of life.Patients with troublesome cough may describe a range of additional symptoms and sensations including an 'urge to cough' or the feeling of an 'itch' at the back of the throat, or a choking sensation and occasionally chest pain or breathlessness. It is uncertain if these features arise due to the processes responsible for cough reflex sensitisation or as a direct consequence of the underlying cough aetiology. In an attempt to understand the clinical features of a sensitized cough reflex, the spectrum of symptoms typically described by cough patients will be reviewed and possible underlying mechanisms considered. Since an intact cough reflex is crucial to airway protection, anti-tussive treatment that attenuates the hypersensitive cough state rather than abolishing the cough reflex completely would be preferable. Identifying such agents remains a clinical, scientific and pharmacological challenge.

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“…The ACCP guidelines [14] evaluate each component of the ADP and provide a set of user-friendly guides for clinical practice on the major causes of cough and treatment recommendations. The European Respiratory Society guidelines [15] suggest two pathways, one using an empirical approach or recommended investigations that can be used in parallel. The British Thoracic Society guidelines [16] cover not only CC but also acute cough and the organization of cough clinics.…”

Section: Introductionmentioning

confidence: 99%

An update and systematic review on drug therapies for the treatment of refractory chronic cough

Ryan

Vertigan

Birring

2018

Expert Opinion on Pharmacotherapy

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Introduction: Chronic Cough (CC) is common and often associated with significant comorbidity and decreased quality of life. In up to 50% of cases, the cough is refractory despite extensive investigation and treatment trials. It is likely that the key abnormality in refractory CC is dysfunctional, hypersensitive sensory nerves, similar to conditions such as laryngeal hypersensitivity and neuropathic pain.Areas covered: The aim of this systematic review is to assess drug therapies for refractory CC. The authors review the current management of CC and provide discussion of the similarities between neuropathic pain and refractory CC. They review repurposed and new pharmacological treatments. Several meta-analyses were performed to compare the efficacy of treatments where possible.Expert opinion: Repurposed pain medications such as gabapentin and pregabalin reduce the frequency of cough and improve quality of life. Along with speech pathology, they are important and alternate treatments for refractory CC. However, more treatments are needed and the P2X3 ion channel receptor antagonists show the most promise. With a better understanding of neuronal activation and sensitisation and their signal processing in the brain, improved animal models of cough, and the use of validated cough measurement tools, more effective treatments will develop.

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ERS guidelines on the assessment of cough

Cited by 613 publications

References 147 publications

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Inhaled ethanol potentiates the cough response to capsaicin in patients with airway sensory hyperreactivity

Are there clinical features of a sensitized cough reflex?

An update and systematic review on drug therapies for the treatment of refractory chronic cough

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