2020
DOI: 10.33549/physiolres.934399
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Cough Reflex Sensitivity in Asthmatic Children

Abstract: New knowledge about the neural aspects of cough has revealed a complex network of pathways that initiate cough. The effect of inflammation on cough neural processing occurs at multiple peripheral and central sites within the nervous system. Evidence exists that direct or indirect neuroimmune interaction induces a complex response, which can be altered by mediators released by the sensory or parasympathetic neurons and vice versa. The aim of this study was to clarify changes of cough reflex sensitivity – the ac… Show more

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Cited by 7 publications
(5 citation statements)
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“…Further, in children (unlike adults), persistent cough sensitivity has not been found in the common causes e.g., viral infections in children with asthma [22], to significantly change post intervention e.g., post adenoidectomy [43], or in situations where cough is expected to occur (post-exercise in children with asthma [44]). Additionally, cough sensitivity has been shown to be not consistently elevated in children, e.g., C5 (concentration of capsaicin that trigger five or more coughs) was no different between children with asthma and controls (though C2 was significantly different) [45], whereas the reverse was described in children with cystic fibrosis [37].…”
Section: Why Assigning Cough Hypersensitivity Syndrome As a Diagnosti...mentioning
confidence: 99%
“…Further, in children (unlike adults), persistent cough sensitivity has not been found in the common causes e.g., viral infections in children with asthma [22], to significantly change post intervention e.g., post adenoidectomy [43], or in situations where cough is expected to occur (post-exercise in children with asthma [44]). Additionally, cough sensitivity has been shown to be not consistently elevated in children, e.g., C5 (concentration of capsaicin that trigger five or more coughs) was no different between children with asthma and controls (though C2 was significantly different) [45], whereas the reverse was described in children with cystic fibrosis [37].…”
Section: Why Assigning Cough Hypersensitivity Syndrome As a Diagnosti...mentioning
confidence: 99%
“…Typically, mediators released during inflammation in allergic airway diseases can alter the function of the sensory and parasympathetic nervous systems, innervating the airways (19). The effect of inflammation on cough neural processing occurs at multiple peripheral and central sites within the nervous system (20). Moreover, allergen-induced bronchoconstriction and airway eosinophilia are associated with increased cough reflex sensitivity to capsaicin (21).…”
Section: Aetiological Causes Of Chronic Coughmentioning
confidence: 99%
“…Some subjects report transient throat irritation. 4 33 34 35 36 There are several studies applying single-breath, dosimetric capsaicin tests in large groups of healthy subjects. 1 3 18 21 30 35 37 Prudon et al .…”
Section: Cough Reflex Sensitivity In Healthy Subjectsmentioning
confidence: 99%
“… 29 A recent study reported a lower capsaicin C2, but not C5, in asthmatic children than in the control subjects. 36 The capsaicin sensitivity in asthma may be associated with the subjective cough severity 18 and poor asthma control. 63 It is possible that the distinction between healthy and asthmatic subjects is better if maximum cough responses are used instead of threshold values to describe the cough responsiveness.…”
Section: Cough Reflex Sensitivity In Respiratory Diseases and Comparison With Healthy Subjectsmentioning
confidence: 99%