Cough Variant Asthma as a Phenotype of Classic Asthma

Vujnović, Sanela Domuz; Domuz, Adrijana; Petrovic, Slobodanka

doi:10.5772/intechopen.75152

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Asthma sometimes manifests itself as a chronic cough called cough-variant asthma (CVA), and in several cases, it is difficult to be diagnosed. Studies show that about 25% to DOI:10.34172/ipp.2022.31351 30% of these patients experience the signs and symptoms of classic asthma over time (12,13). According to studies, CVA seems to be one of the most important causes of chronic cough worldwide.…”

Section: Key Pointmentioning

confidence: 99%

Evaluation of methacholine challenge test results in patients with chronic unexplained cough

2022

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Introduction: Asthma is one of the most common chronic diseases in adults characterized by variable airway obstruction. Asthma is diagnosed with wheezing and shortness of breath, however it sometimes manifests as a chronic cough that is difficult to diagnose and requires spirometry stimulation tests. Objectives: This study aimed to investigate the relationship between methacholine test results and respiratory symptoms in patients with chronic unexplained cough. Patients and Methods: In this cross-sectional study, 102 patients with chronic cough and normal basal spirometry were included. All patients underwent a methacholine challenge test, and their airway irritabilities were assessed. Then, the relationship between methacholine test results and clinical symptoms and also demographic characteristics were investigated. Results: Of 102 patients, 69 (67.6 %) and 33 (32.4%) were female and male, respectively. Most of patients were non-smoker (90.2%). Around 25 (24.5%) patients had a positive methacholine test. Rhinitis had a statistically significant difference between patients with positive and negative tests (positive test group: 48%, negative test group: 23.4%; P = 0.01). Postnasal discharge was reported in 60% of positive methacholine test patients, which was significant compared to the negative group (36.4%; P = 0.03). Most patients who had positive tests were housewives (76%). Logistic regression showed that female gender (OR: 7.75, 95% CI: 1.7-35.2), postnasal discharge (OR: 3.19, 95% CI: 1.25-8.2), rhinitis (OR: 3.02, 95% CI: 1.17-7.79), and allergy symptoms OR: 3.51, 95% CI: 1.35-9.18) were directly associated with a positive methacholine test. Conclusion: The presence of airway hypersensitivity, postnasal discharge, allergic rhinitis, female gender and the housewife’s job were strongly associated with a positive methacholine test.

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Section: Key Pointmentioning

confidence: 99%

Evaluation of methacholine challenge test results in patients with chronic unexplained cough

2022

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“…Cough variant asthma (CVA) is a cough phenotypic trait which lacks wheezing or dyspnea and is associated with airway hyperresponsiveness ( Table 1 ) and a favorable response to anti-asthma medications. 138 Patients with CVA can account for around 30% of chronic cough referrals 139 and can present solely or predominantly with cough 129 , 140 in response to innocuous triggers such as talking and laughing, allergens and cold air. 141 , 142 Currently there is insufficient data to speculate if CVA is a precursor of classic asthma or a separate cough phenotype.…”

Section: Lower Airway Cough Syndromementioning

confidence: 99%

WAO-ARIA consensus on chronic cough - Part II: Phenotypes and mechanisms of abnormal cough presentation — Updates in COVID-19

Rouadi

Idriss

Bousquet

et al. 2021

World Allergy Organization Journal

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Background: Chronic cough can be triggered by respiratory and non-respiratory tract illnesses originating mainly from the upper and lower airways, and the GI tract (ie, reflux). Recent findings suggest it can also be a prominent feature in obstructive sleep apnea (OSA), laryngeal hyperresponsiveness, and COVID-19. The classification of chronic cough is constantly updated but lacks clear definition. Epidemiological data on the prevalence of chronic cough are informative but highly variable. The underlying mechanism of chronic cough is a neurogenic inflammation of the cough reflex which becomes hypersensitive, thus the term hypersensitive cough reflex (HCR). A current challenge is to decipher how various infectious and inflammatory airway diseases and esophageal reflux, among others, modulate HCR. Objectives:The World Allergy Organization/Allergic Rhinitis and its Impact on Asthma (WAO/ ARIA) Joint Committee on Chronic Cough reviewed the current literature on classification, epidemiology, presenting features, and mechanistic pathways of chronic cough in airway-and reflux-related cough phenotypes, OSA, and COVID-19. The interplay of cough reflex sensitivity

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Cough Variant Asthma as a Phenotype of Classic Asthma

Cited by 2 publications

References 29 publications

Evaluation of methacholine challenge test results in patients with chronic unexplained cough

Evaluation of methacholine challenge test results in patients with chronic unexplained cough

WAO-ARIA consensus on chronic cough - Part II: Phenotypes and mechanisms of abnormal cough presentation — Updates in COVID-19

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