Could a bacteria-stuffed pill cure autoimmune diseases?

Abstract

the day a women he was treating for lupus was visited by her identical twin sister was a watershed moment. The sister was a picture of health, with a one-year-old child in her arms. Silverman's patient, meanwhile, was receiving kidney dialysis and, despite his best efforts, her condition was getting worse. "Genetics was not going to explain this difference," says Silverman. The revelation launched him on a decades-long quest to seek out other factors that drive the puzzling autoimmune disease. Researchers investigating other autoimmune diseases have also been looking beyond genetics. In the case of type 1 diabetes, the epidemiological evidence for doing so is overwhelming, says Jayne Danska, a geneticist at the Hospital for Sick Children in Toronto, Canada. Genetics "doesn't explain why the incidence of the disease has been rising over Micrograph of a spinal cord affected by multiple sclerosis. "We want to understand the rules that regulate the bacterial society in the gut." RICCARDO CASSIANI-INGONI/SPL

Impact of Gut Microbiota and Microbiota-Related Metabolites on Hyperlipidemia

“…The total amount of gut microbiota genes is 100 times that of human genes and is known as the “second genome” of humans ( Moeller et al., 2012 ; Komaroff, 2018 ). Gut microbiota serves several functions in host metabolism, such as supplementing body nutrition ( Du Toit, 2016 ), promoting immunity ( Bender, 2020 ), and protecting the intestinal barrier ( Shin and Kim, 2018 ). Given its regulatory role in host lipid metabolism, gut microbiota has been highly associated with hyperlipidemia and related diseases ( He et al., 2016 ).…”

Herbal medicine and its impact on the gut microbiota in colorectal cancer

“…It is estimated that the total amount of GM genes is 100 times that of human genes ( Komaroff, 2018 ). GM serves several functions in host metabolism, such as promoting immunity and protecting the intestinal barrier ( Shin and Kim, 2018 ; Bender, 2020 ). Intestinal dysbiosis reduces the function of the intestinal mucosal barrier and enhances bacterial translocation, leading to inflammation and infection.…”

Electroacupuncture at Lower He-Sea and Front-Mu Acupoints Ameliorates Insulin Resistance in Type 2 Diabetes Mellitus by Regulating the Intestinal Flora and Gut Barrier

“…4 The gut microbiome is a complex system of trillions of bacteria, fungi and viruses. 5 The intestinal microbiota plays a variety of roles in host metabolism, such as promoting immunity 6 and maintaining lipid metabolism homeostasis, 7 which contribute to the occurrence and development of diabetes. 8 The human intestine is an important barrier, and the intestinal flora, as a relatively complete ecosystem, can affect the function of the intestinal mucosal barrier.…”