Could Helium Plasma Treatment be a Novel Approach to Prevent the Biofilm Formation of Candida albicans?

Avukat, Esra Nur; Akay, Canan; Ersöz, Mirac Berke Topcu; Mumcu, Emre; Quan, Li Na; Erdönmez, Demet

doi:10.1007/s11046-023-00747-9

Mycopathologia

2023

DOI: 10.1007/s11046-023-00747-9

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Could Helium Plasma Treatment be a Novel Approach to Prevent the Biofilm Formation of Candida albicans?

Esra Nur Avukat

Canan Akay

Mirac Berke Topcu Ersöz³

et al.

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2024

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Cited by 2 publications

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Disinfection of dental root canals by cold atmospheric plasma: a systematic review and meta-analysis of dental biofilm

Sanesi,

Puca,

Caponio

et al. 2024

Front. Oral. Health

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AimThe intricate structure of the tooth root canals has a role in the colonization and biofilm formation in hidden areas that are hardly reached by standard endodontic treatments. This review aims at summarizing data from in vitro and ex vivo studies for a better understanding of the application of cold atmospheric plasma (CAP) for the disinfection of dental root canals.MethodsPubMed, Scopus, and Web of Science databases were screened. Characteristics of the included studies were extracted, and a meta-analysis on ex vivo studies was carried out to evaluate the effect of CAP on colony forming unit assay of Enterococcus faecalis (E. faecalis). The study was performed following the PRISMA 2020 guidelines.ResultsA total of 31 studies fulfilled the selection criteria. Only 2 investigations reported an indirect plasma treatment, 28 trials used direct CAP administration, while 1 study applied both methods. Most of the studies were conducted on E. faecalis using as carrier gas Helium or Argon alone or in combination with Oxygen as well air. A considerable heterogeneity among studies was found regarding treatments which varied for source type, settings, and protocols of application. Despite this, CAP showed effectiveness in reducing E. faecalis colony forming unit with a standardized mean difference of 4.51, 95% C.I. = 2.55–6.48, p-value < 0.001.ConclusionThe data demonstrated the antimicrobial effect of direct CAP application against microorganisms. In-vitro studies showed an effect that depended on the time and distance of treatment, while the meta-analysis performed on ex vivo studies showed that the effect of CAP was independent of time and distance.Systematic Review Registrationhttps://doi.org/10.17605/OSF.IO/BJ59V, identifier OSF registries.

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Disinfection of dental root canals by cold atmospheric plasma: a systematic review and meta-analysis of dental biofilm

Sanesi,

Puca,

Caponio

et al. 2024

Front. Oral. Health

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Evaluation of the Effects of Dielectric Barrier Discharge Plasma on Candida albicans Strains: An in vitro Study

Najafi,

Lotfali,

Shoorgashti

et al. 2024

Jundishapur J Microbiol

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Background: Antifungal resistance is increasing, posing a challenge for treating candidiasis. Cold atmospheric plasma (CAP) is a potential alternative, but its association with traditional antifungals is poorly understood. Objectives: This study aims to evaluate the effects of dielectric barrier discharge (DBD) plasma on Candida albicans. Methods: In this in vitro study, C. albicans strains were irradiated with DBD plasma for 5, 10, and 15 minutes, both with and without nystatin. The number of colonies was counted, and the MTT method assessed Candida's survival. Data were analyzed with SPSS26. Results: This study showed that in both experimental groups, with and without nystatin, the lowest C. albicans cell viability was observed following a 10 minute DBD exposure within the groups subjected to plasma treatment (P < 0.001). The positive control group (nystatin without plasma exposure) exhibited a diminished count of viable cells in comparison to the group with 10 minute plasma irradiation without nystatin (P < 0.001). The 10 and 15 minute DBD plasma exposures, along with their positive control counterparts, demonstrated a statistically significant reduction in colony count compared to the 5 minute DBD exposure and the negative control groups (P < 0.001). Conclusions: Nystatin was more effective than DBD plasma irradiation in reducing C. albicans cell viability. When used in combination, 10 minute DBD plasma irradiation with nystatin was more effective than 5 or 15 minute irradiation times in reducing the survival rate of C. albicans.

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Could Helium Plasma Treatment be a Novel Approach to Prevent the Biofilm Formation of Candida albicans?

Cited by 2 publications

References 35 publications

Disinfection of dental root canals by cold atmospheric plasma: a systematic review and meta-analysis of dental biofilm

Disinfection of dental root canals by cold atmospheric plasma: a systematic review and meta-analysis of dental biofilm

Evaluation of the Effects of Dielectric Barrier Discharge Plasma on Candida albicans Strains: An in vitro Study

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