Could<i>Helicobacter pylori</i>play a role in the aetiopathogenesis of tympanosclerosis?

İriz, Ayşe; Eryılmaz, Adil; Göçer, Celil; Acar, Ali; Boynueğri, Süleyman; Dursun, Engin

doi:10.1017/s0022215111002301

Cited by 13 publications

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“…Although there are many studies concerning TS, the pathogenesis of TS is still poorly understood. Infection, trauma, genetic tendency, immunological reaction and Helicobacter pylori have been suggested as possible causative factors for TS [13][14][15][16][17] Because of the similar pathological mechanism between TS and AS, the incidence of TS was investigated in patients with AS. Koç and Uneri [14] found a high incidence rate of TS in atherosclerotic patients.…”

Section: Discussionmentioning

confidence: 99%

Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels

Doğan¹

2016

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Bu çalışmada yaygın timpanosklerozis ile serum kalsiyum, fosfor, D vitamini ve paratiroid hormonu düzeyleri arasındaki ilişki araştırıldı. Hastalar ve Yöntemler: Bu çalışma, Ekim 2014-Mayıs 2015 tarihleri arasında, Kayseri Eğitim Araştırma Hastanesi Kulak Burun Boğaz ve Baş Boyun Cerrahisi Bölümü'nde yürütüldü. Yaygın timpanosklerozis tanısı konulan 37 hasta (18 erkek, 19 kadın; ort. yaş 35.4 yıl; dağılım 18-77 yıl) ile çalışma grubu oluşturuldu. Otuz iki sağlıklı birey (15 erkek, 17 kadın; ort. yaş 32.2 yıl; dağılım 18-67 yıl) kontrol grubu olarak alındı. Çalışmaya katılan her bireyin serum total kalsiyum, fosfor, D vitamini, paratiroid hormonu ve albümin düzeyleri analiz edildi. Serum albümin ile düzeltilmiş kalsiyum değerlerini elde etmek için, total kalsiyum seviyeleri serum albümin seviyelerine göre düzeltildi. Bulgular: Ortalama serum fosfor, D vitamini ve paratiroid hormonu değerleri çalışma grubunda anlamlı oranda yüksek iken, serum total kalsiyum ve albümin ile düzeltilmiş kalsiyum değerleri bakımından iki grup arasında anlamlı fark yoktu. Sonuç: Her ne kadar bu çalışma grubunda serum fosfor, D vitamini ve paratiroid hormonu düzeyleri ile yaygın timpanosklerozis arasında ilişki bulunsa da bu serum parametrelerinin, timpanosklerozis gelişiminin hücresel mekanizmalarındaki potansiyel rolü üzerine ileri çalışmalara ihtiyaç vardır.

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Section: Discussionmentioning

confidence: 99%

Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels

Doğan¹

2016

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“…Iriz et al ( 26 ) showed that there are similar risk factors, such as increased homocysteine levels, between coronary artery atherosclerosis and tympanosclerosis. Although tympanosclerosis and atherosclerosis are two separate pathologies, they have similar histological and pathophysiologic elements and the same genetic reason has been proposed for both ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…Iriz et al ( 26 ) carried out a case-control study and found that 100% of the patients with tympanosclerosis were H. Pylori -positive while only 26.9% of the patients not suffering from tympanosclerosis were H. Pylori -positive (P < 0.01) ( 21 ). Results of our study, while confirming those of Iriz et al ( 26 ), were different. This difference could be due the method used in the identification of H. Pylori .…”

Section: Discussionmentioning

confidence: 99%

“…This difference could be due the method used in the identification of H. Pylori . Iriz et al ( 26 ) used the campylobacter-like organism (CLO) test in H. Pylori identification, while we employed the PCR method. Since the PCR method is more accurate than the CLO test, our results are probably more acceptable than those Iriz et al ( 26 ) found.…”

Section: Discussionmentioning

confidence: 99%

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Correlation Between Tympanosclerosis and Helicobacter pylori

Saki

Jahani

Samarbaf

et al. 2015

Jundishapur J Microbiol

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Background:Tympanosclerosis is a condition caused by calcification of tissues in the middle ear mucosa that sometimes results hearing loss. Helicobacter pylori is one of the pathological and etiologic factors in the development of tympanosclerosis.Objectives:The purpose of this study was to show the role of H. pylori in the different aspects of chronic suppurative otitis media using the polymerase chain reaction (PCR) technique.Patients and Methods:This case-control and cross-sectional study was performed on all patients with chronic otitis media, candidates for surgical operations, in 2013. They were allocated into the case group with tympanosclerosis and the control group without tympanosclerosis. During the surgical operation, biopsy was done from middle ear and the samples were studied to see if they contained H. pylori using the PCR method.Results:From a total of 19 patients with tympanosclerosis , 16 cases (84.2%) were H. pylori positive, while in the control group 15 (45.4%) cases out of the 37 cases were H. pylori positive, which showed a significant difference (P = 0.002). Age and gender of the patients, ear dryness and perforation size were not correlated with the presence or absence of H. pylori.Conclusions:There is a significant correlation between tympanosclerosis and H. pylori (P = 0.002). This correlation can single out H. pylori as a pathological factor in the development of tympanosclerosis; however, further studies are needed to prove this correlation.

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“…This disease could be the complication of chronic otitis media [23]. Iriz et al, have demonstrated that H. pylori could be one of the reasons of tympanosclerosis [24]. Although otitis media is more common in children, Yazdi et al, have found a relationship between chronic otitis media and gastroesophageal reflux in adults [25].…”

Section: Hypothesismentioning

confidence: 99%

Associations between peripheral vertigo and gastroesophageal reflux disease

et al. 2015

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CouldHelicobacter pyloriplay a role in the aetiopathogenesis of tympanosclerosis?

Abstract: This study represents a preliminary investigation of the association between H pylori and tympanosclerosis development.

Cited by 13 publications

References 19 publications

Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels

Association between extensive tympanosclerosis and serum calcium, phosphorus, vitamin D, and parathyroid hormone levels

Correlation Between Tympanosclerosis and Helicobacter pylori

Associations between peripheral vertigo and gastroesophageal reflux disease

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