Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats?

Pereira, Olga; Bernardi, Maria Martha; Gerardin, Daniela Cristina Ceccatto

doi:10.1016/j.lfs.2005.10.035

Cited by 38 publications

(18 citation statements)

References 38 publications

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“…Disturbances during this phase may alter reproductive physiology and behavior (Gerardin et al 2005;Pereira et al 2006;Reznikov and Tarasenko 2007;Ward and Weisz 1980). Sexual differentiation in the brain occurs during the late gestational and early postnatal days.…”

Section: Introductionmentioning

confidence: 99%

Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression

et al. 2011

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Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of this study was to investigate the effect of gestational maternal glyphosate exposure (50 mg/kg, NOAEL for reproductive toxicity) on the reproductive development of male offspring. Sixty-day-old male rat offspring were evaluated for sexual behavior and partner preference; serum testosterone concentrations, estradiol, FSH and LH; the mRNA and protein content of LH and FSH; sperm production and the morphology of the seminiferous epithelium; and the weight of the testes, epididymis and seminal vesicles. The growth, the weight and age at puberty of the animals were also recorded to evaluate the effect of the treatment. The most important findings were increases in sexual partner preference scores and the latency time to the first mount; testosterone and estradiol serum concentrations; the mRNA expression and protein content in the pituitary gland and the serum concentration of LH; sperm production and reserves; and the height of the germinal epithelium of seminiferous tubules. We also observed an early onset of puberty but no effect on the body growth in these animals. These results suggest that maternal exposure to glyphosate disturbed the masculinization process and promoted behavioral changes and histological and endocrine problems in reproductive parameters. These changes associated with the hypersecretion of androgens increased gonadal activity and sperm production.

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Section: Introductionmentioning

confidence: 99%

Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression

et al. 2011

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“…It has been hypothesized that prenatal stress disrupts the normal maternal hormonal milieu and suppresses the fetal testosterone peak on gestational days (GD) 18 and 19, a peak necessary for later expression and maintenance of male sexual behavior [3,24] . In addition, the critical period for the organizational actions of the gonadal hormones on the sexual differentiation of the rat brain extends from approximately the last week of prenatal life through the first postnatal week [23,25,26] .…”

Section: Introductionmentioning

confidence: 99%

Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood

Bernardi

Kirsten

Matsuoka

et al. 2009

Neuroimmunomodulation

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Objective: This study investigates the effects of prenatal lipopolysaccharide (LPS) exposure on the maternal behavior of pregnant rats and the physical development and sexual behavior of their male offspring in adulthood. Methods: For two experiments, pregnant rats were injected with LPS (250 μg/kg, i.p.) on gestation day (GD) 21. In the first experiment, the maternal behavior (postnatal day, PND, 6) and the dam’s open-field general activity (PND7) were evaluated. In the second experiment, the maternal pre- and postnatal parameters, the pup’s development, the offspring’s sexual behavior in adulthood, and the pup’s organ weights were assessed. Results: Compared to the control group, the LPS-treated dams presented reduced maternal behavior, decreased general activity, a smaller body weight difference between GD21 and PND1, a greater number of perinatal deaths, and smaller litters. For the male pups, LPS treatment resulted in a decreased body weight on PND2, whereas the anogenital distance and the day of testis descent were not modified. The male sexual behavior was impaired by prenatal LPS. Particularly the number of ejaculating animals was reduced. The testis weight was also lower in the prenatally LPS-treated rats than in the control rats. Conclusion: We propose that prenatal LPS exposure on GD21 acts as an imprinting factor that interferes with the programming of brain sexual determination in offspring.

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“…In our hands, we have shown that prenatal stress induced long-term imbalance of male sexual hormons concentrations in serum, advanced the spermatogenesis development and exerted an age-dependent misbalance on alpha receptor expression on PFC and HPC brain areas (Pallares et al, 2013a,b). Moreover, it was observed that physiological and behavioral damage caused by prenatal stress was prevented by replacement with neonatal testosterone (Pereira et al, 2006), corroborating the importance of neonatal testosterone surge during the sexual differentiation process of the brain. The fetal rat brain expresses androgen receptors (ARs) as early as GD 12 with a peak expression at GD 17-18 (Brannvall et al, 2005).…”

Section: Introductionmentioning

confidence: 54%

Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring

et al. 2014

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Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats?

Cited by 38 publications

References 38 publications

Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression

Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression

Prenatal Lipopolysaccharide Exposure Affects Maternal Behavior and Male Offspring Sexual Behavior in Adulthood

Maternal administration of flutamide during late gestation affects the brain and reproductive organs development in the rat male offspring

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