Could Neutrophil Extracellular Traps Be the New Prognostic Markers of Cancer?

Rivera-Franco, Mónica M.; Sevilla-González, María de la Luz

doi:10.24875/ric.19003155

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…The pro-tumoral effects of NETs are suggestive of their potential as a novel prognostic predictor of cancers ( 123 ), which has been reported in several studies. Elevated levels of NETs are strongly associated with a higher risk of metastasis.…”

Section: Potential Value Of Nets For Clinical Applicationmentioning

confidence: 72%

The Significance of Neutrophil Extracellular Traps in Colorectal Cancer and Beyond: From Bench to Bedside

Shao

Cao

et al. 2022

Front. Oncol.

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Neutrophil extracellular traps (NETs), products of neutrophil death when exposed to certain stimuli, were first proposed as a type of response to bacterial infection in infectious diseases. Since then, extensive studies have discovered its involvement in other non-infectious inflammatory diseases including thromboembolism, autoimmune diseases, and cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. NET formation is closely associated with tumorigenesis, progression, and metastasis in CRC. Therefore, the application of NETs in clinical practice as diagnostic biomarkers, therapeutic targets, and prognostic predictors has a promising prospect. In addition, therapeutics targeting NETs are significantly efficient in halting tumor progression in preclinical cancer models, which further indicates its potential clinical utility in cancer treatment. This review focuses on the stimuli of NETosis, its pro-tumorigenic activity, and prospective clinical utility primarily in but not limited to CRC.

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Section: Potential Value Of Nets For Clinical Applicationmentioning

confidence: 72%

The Significance of Neutrophil Extracellular Traps in Colorectal Cancer and Beyond: From Bench to Bedside

Shao

Cao

et al. 2022

Front. Oncol.

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“…86 Other common sites where cancer cells spread include the liver, lungs, etc. 87 The quantity of NETs correlates with the degree of breast cancer lung metastasis. 61 Xiao et al 88 discovered that cathepsin C (CTSC) secreted by tumors promoted the lung metastasis of breast cancer cells by regulating the infiltration of neutrophils and the formation of NETs in the metastatic microenvironment.…”

Section: Nets Promote Tumor Metastasismentioning

confidence: 99%

Regulation of neutrophil extracellular traps in cancer

Xia,

Zhang,

Huang

et al. 2023

Intl Journal of Cancer

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Neutrophil extracellular trap (NET) is one of the defense functions of neutrophils, which has a rapid ability to kill infections and is also crucial in a variety of immune‐associated diseases including infections, tumors and autoimmune diseases. Recent studies have shown that NETs are closely related to the development of tumors. The regulatory role of NETs in tumors has been of interest to researchers. In addition to awakening latent tumor cells, NETs can also promote the proliferation and development of tumor cells and their metastasis to other sites. At the same time, NETs also have the effect of inhibiting tumors. At present, there are some new advances in the impact of NETs on tumor development, which will provide a more theoretical basis for developing NET‐targeted drugs. Therefore, this review just summarized the formation process of NETs, the regulation of tumor development and the treatment methods based on NETs.

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“…Neutrophils guard against pathogens through phagocytosis, the production of reactive oxygen species (ROS), the formation of neutrophil extracellular traps (NETs), etc., contributing to the host‘s defense system [ 10 , 11 , 12 , 13 ]. NETs, consisting of chromatin DNA scaffolds coated with granular proteins, promote BC metastasis by enhancing tumor cell migration to distant organs, including lung tissue [ 13 , 14 , 15 ]. Moreover, the content of NETs is positively associated with the lung metastasis of BC [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Dihydrotanshinone I Inhibits the Lung Metastasis of Breast Cancer by Suppressing Neutrophil Extracellular Traps Formation

Zhao

Liang

Sun

et al. 2022

IJMS

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Breast cancer (BC) is a common female malignancy, worldwide. BC death is predominantly caused by lung metastasis. According to previous studies, Dihydrotanshinone I (DHT), a bioactive compound in Salvia miltiorrhiza Bunge (S. miltiorrhiza), has inhibitory effects on numerous cancers. Here, we investigated the anti-metastatic effect of DHT on BC, where DHT more strongly inhibited the growth of BC cells (MDA-MB-231, 4T1, MCF-7, and SKBR-3) than breast epithelial cells (MCF-10a). Additionally, DHT repressed the wound healing, invasion, and migration activities of 4T1 cells. In the 4T1 spontaneous metastasis model, DHT (20 mg/kg) blocked metastasis progression and distribution in the lung tissue by 74.9%. DHT reversed the formation of neutrophil extracellular traps (NETs) induced by phorbol 12-myristate 13-acetate, as well as ameliorated NETs-induced metastasis. Furthermore, it inhibited Ly6G+Mpo+ neutrophils infiltration and H3Cit expression in the lung tissues. RNA sequencing, western blot, and bioinformatical analysis indicated that TIMP1 could modulate DHT acting on lung metastasis inhibition. The study demonstrated a novel suppression mechanism of DHT on NETs formation to inhibit BC metastasis.

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Could Neutrophil Extracellular Traps Be the New Prognostic Markers of Cancer?

Cited by 4 publications

References 8 publications

The Significance of Neutrophil Extracellular Traps in Colorectal Cancer and Beyond: From Bench to Bedside

The Significance of Neutrophil Extracellular Traps in Colorectal Cancer and Beyond: From Bench to Bedside

Regulation of neutrophil extracellular traps in cancer

Dihydrotanshinone I Inhibits the Lung Metastasis of Breast Cancer by Suppressing Neutrophil Extracellular Traps Formation

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