Coumarin and Flavone Derivatives from Estragon and Thyme as Inhibitors of Chemical Mediator Release from RBL-2H3 Cells

Watanabe, Jun; Shinmoto, Hiroshi; Tsushida, Tojiro

doi:10.1271/bbb.69.1

Cited by 49 publications

(24 citation statements)

References 20 publications

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“…Although no constituents could be linked to the immunomodulatory properties of the plant at this stage, studies have shown that different types of lignans may stimulate human peripheral blood leukocyte proliferation [25]. Coumarins and polyacetylenes have reported to cause the inhibition of macrophages, T lymphocytes, eosinophils, mast cells, and mucus secretion; hence they are useful in several diseases of immune dysfunction [26,27].…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Pozharitskaya¹,

Shikov²,

Косман³

et al. 2015

Synergy

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Pozharitskaya¹,

Shikov²,

Косман³

et al. 2015

Synergy

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“…Numerous hydroxylated polymethoxyflavones have been isolated primarily from orange juice, citrus peel, and dried tangerine peels (Takanaga et al, 2000;Hirata et al, 2009;Sun et al, 2009;Xiao et al, 2009;Zheng et al, 2009;Dong et al, 2010), including nobiletin, tangeretin, artemetin (Ahmed et al, 1988;Sertié et al, 1990), and sinensetin (Choi et al, 2002). Besides citrus, PMF analogs have also been identified from the spice thyme and estragon (Watanabe et al, 2005). The compound isolated from Gardenia species and used in our studies is 5, 3Ј-dihydroxy-3,6,7,8,4Ј-pentamethoxyflavone.…”

Section: Discussionmentioning

confidence: 99%

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

Phromnoi

Reuter

Sung

et al. 2011

Molecular Pharmacology

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Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3Ј-dihydroxy-3,6,7,8,4Ј-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-B (NF-B) pathway is linked to inflammation and tumorigenesis, we investigated the effect of PMF on this pathway. We found that PMF suppressed NF-B activation induced by inflammatory agents, tumor promoters, and carcinogens. This suppression was not specific to the cell type. Although PMF did not directly modify the ability of NF-〉 proteins to bind to DNA, it inhibited IB␣ (inhibitory subunit of NF-B) kinase, leading to suppression of phosphorylation and degradation of IB␣, and suppressed consequent p65 nuclear translocation, thus abrogating NF-B-dependent reporter gene expression.Suppression of the NF-B cell signaling pathway by the flavone led to the inhibition of expression of NF-B-regulated gene products that mediate inflammation (cyclooxygenase-2), survival (XIAP, survivin, Bcl-xL, and cFLIP), proliferation (cyclin D1), invasion (matrix metalloproteinase-9), and angiogenesis (vascular endothelial growth factor). Suppression of antiapoptotic gene products by PMF correlated with the enhancement of apoptosis induced by tumor necrosis factor-␣ and the chemotherapeutic agents cisplatin, paclitaxel, and 5-flurouracil. Overall, our results indicate that PMF suppresses the activation of NF-B and NF-B-regulated gene expression, leading to the enhancement of apoptosis. This is the first report to demonstrate that this novel flavone has anti-inflammatory and anticancer effects by targeting the IKK complex.

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“…The inhibitory activity against the release of β-hexosaminidase from RBL-2H3 cells was evaluated by a modifying of the method of Watanabe et al 17) RBL-2H3 cells were purchased from the JCRB Cell Bank (Osaka, Japan). Dulbecco's-modified Eagle's medium containing 10% heat-inactivated fetal bovine serum was used as a growth medium.…”

Section: Evaluation Of Degranulation-inhibiting Activitymentioning

confidence: 99%

Syntheses and biological activities of the proposed structure of apteniol A and its derivatives

Nishikawa

Noshita

Tai

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester derivative of the proposed apteniol A was found to enhance neurite outgrowth in PC12 cells and inhibit antigen-induced degranulation in RBL-2H3 cells.

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Coumarin and Flavone Derivatives from Estragon and Thyme as Inhibitors of Chemical Mediator Release from RBL-2H3 Cells

Cited by 49 publications

References 20 publications

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

RETRACTION: A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of IκB Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

Syntheses and biological activities of the proposed structure of apteniol A and its derivatives

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