Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Pozharitskaya, Olga N.; Shikov, Alexander N.; Косман, В. М.; Selezneva, Arina I.; Уракова, И. Н.; Макарова, М.Н.; Makarov, Valery G.

doi:10.1016/j.synres.2015.07.001

Cited by 11 publications

(10 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The discovery of the impact of individual compounds/fractions on the antioxidant activities of natural extracts is challenging [36,72]. The mixture effect (ME) is one of the common approaches for expressing the synergistic or antagonistic effects occurring between pairs of antioxidants in a mixture [72,73]. To investigate ME, solutions of AA and phloroglucinol and their mixture were prepared and their ability to scavenge DPPH radicals was studied.…”

Section: Determination Of the Mixture Effectmentioning

confidence: 99%

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

et al. 2021

Self Cite

View full text Add to dashboard Cite

The impact of the composition of natural deep eutectic solvents (NADES) and extraction conditions on the simultaneous extraction of hydrophilic ascorbic acid (AA), phlorotannins (TPhC), and lipophilic fucoxanthin (FX) from Fucus vesiculosus was investigated for the first time. In biological tests, the NADES extracts showed the promising ability to scavenge DPPH radicals. A positive correlation was observed between DPPH scavenging activity and AA, TPhC, and FX contents. We calculate the synergistic effect of antioxidants extracted by NADES from F. vesiculosus based on the mixture effect (ME). The addition of 30% water to the NADES and the prolongation of sonication time from 20 min up to 60 min were favorable for the ME. The ME for extracts with the NADES was increased by two folds (ME > 2). In contrast, conventional extraction by maceration with steering at 60 °C does not lead to the synergistic effect (ME = 1). It is notable that the NADES provides high stability and preserves the antioxidant activity of the extracts from F. vesiculosus during storage.

show abstract

Section: Determination Of the Mixture Effectmentioning

confidence: 99%

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Oil from fish waste was also successfully applied at microbiological level both as bacterial growth substrate and as antimicrobial. The antioxidant as well as the immunomodulatory properties of the combination of fish (salmon) oil with plant extracts was reported by [ 250 ], demonstrating that the synergistic effect lead to an increasing of bioactivity compared with fish oil extract alone.…”

Section: Fish Byproducts As Source Of High Added-value Compoundsmentioning

confidence: 98%

Fish Waste: From Problem to Valuable Resource

et al. 2021

View full text Add to dashboard Cite

Following the growth of the global population and the subsequent rapid increase in urbanization and industrialization, the fisheries and aquaculture production has seen a massive increase driven mainly by the development of fishing technologies. Accordingly, a remarkable increase in the amount of fish waste has been produced around the world; it has been estimated that about two-thirds of the total amount of fish is discarded as waste, creating huge economic and environmental concerns. For this reason, the disposal and recycling of these wastes has become a key issue to be resolved. With the growing attention of the circular economy, the exploitation of underused or discarded marine material can represent a sustainable strategy for the realization of a circular bioeconomy, with the production of materials with high added value. In this study, we underline the enormous role that fish waste can have in the socio-economic sector. This review presents the different compounds with high commercial value obtained by fish byproducts, including collagen, enzymes, and bioactive peptides, and lists their possible applications in different fields.

show abstract

“…Several authors also used preclinical studies to test the effects of the combination of polyphenols, marine omega-3 PUFAs, and other biologically active substances. Fish oil supplemented with plant oil extracts (from Schisandra chinensis and Matricaria chamomilla ), rich in tocopherols, cholecalciferol, retinol, lignans, coumarins, and dicyclo esters, [ 50 ] demonstrated synergistic effects as free radical scavengers compared to controls in mice animal models. Brown seaweed lipids extracts (rich in polyphenols, omega-3, and fucoxanthin) resulting in less lipid peroxidation in the liver of female KK-Ay mice, although the hepatic percentage of PUFAs (especially DHA and AA) increased [ 51 ].…”

Section: Combined Polyphenols and Fish Oils Intake For Improving Metabolic Healthmentioning

confidence: 99%

Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects

Méndez

Medina

2021

Molecules

View full text Add to dashboard Cite

Polyphenols and omega-3 polyunsaturated fatty acids from fish oils, i.e., eicosapentaenoic and docosahexaenoic acids, are well-recognized nutraceuticals, and their single antioxidant and anti-inflammatory properties have been demonstrated in several studies found in the literature. It has been reported that the combination of these nutraceuticals can lead to three-fold increases in glutathione peroxidase activity, two-fold increases in plasma antioxidant capacity, decreases of 50–100% in lipid peroxidation, protein carbonylation, and urinary 8-isoprotanes, as well as 50–200% attenuation of common inflammation biomarkers, among other effects, as compared to their individual capacities. Therefore, the adequate combination of those bioactive food compounds and their single properties should offer a powerful tool for the design of successfully nutritional interventions for the prevention and palliation of a plethora of human metabolic diseases, frequently diet-induced, whose etiology and progression are characterized by redox homeostasis disturbances and a low-grade of chronic inflammation. However, the certain mechanisms behind their biological activities, in vivo interaction (both between them and other food compounds), and their optimal doses and consumption are not well-known yet. Therefore, we review here the recent evidence accumulated during the last decade about the cooperative action between polyphenols and fish oils against diet-related metabolic alterations, focusing on the mechanisms and pathways described and the effects reported. The final objective is to provide useful information for strategies for personalized nutrition based on these nutraceuticals.

show abstract

Immunomodulatory and antioxidants properties of fixed combination of fish oil with plant extracts

Cited by 11 publications

References 45 publications

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

Fish Waste: From Problem to Valuable Resource

Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects

Contact Info

Product

Resources

About