Coumarin and Its Derivatives—Editorial

Matos, María Joäo

doi:10.3390/molecules26206320

Cited by 12 publications

(7 citation statements)

References 26 publications

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“…Coumarins are phenolic compounds that are commonly found in some groups of plants and have been found to have important medicinal properties, including anti-fungal [ 56 ], antibacterial [ 57 ], and anti-tumour activities [ 58 ]. In a recent publication, two natural products identified as coumarin derivatives obtained from the plant Ruta chalepensis have been described for their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral, and calcium antagonistic properties [ 59 ]. Similarly, coumarins from plants such as Gliricidia sepium (Fabaceae) and Ruta chalepensis (Rutaceae) have also been found to show nematocidal activity against gastrointestinal parasitic nematodes, i.e., Cooperia punctata and H. contortus affecting ruminants [ 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Arthrobotrys musiformis (Orbiliales) Kills Haemonchus contortus Infective Larvae (Trichostronylidae) through Its Predatory Activity and Its Fungal Culture Filtrates

et al. 2022

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Haemonchus contortus (Hc) is a parasite affecting small ruminants worldwide. Arthrobotrys musiformis (Am) is a nematode-trapping fungi that captures, destroys and feeds on nematodes. This study assessed the predatory activity (PA) and nematocidal activity (NA) of liquid culture filtrates (LCF) of Am against Hc infective larvae (L3), and additionally, the mycochemical profile (MP) was performed. Fungal identification was achieved by traditional and molecular procedures. The PA of Am against HcL3 was performed in water agar plates. Means of non-predated larvae were recorded and compared with a control group without fungi. LCF/HcL3 interaction was performed using micro-tittering plates. Two media, Czapek–Dox broth (CDB) and sweet potato dextrose broth (SPDB) and three concentrations, were assessed. Lectures were performed after 48 h interaction. The means of alive and dead larvae were recorded and compared with proper negative controls. The PA assessment revealed 71.54% larval reduction (p < 0.01). The highest NA of LCF was found in CDB: 93.42, 73.02 and 51.61%, at 100, 50 and 25 mg/mL, respectively (p < 0.05). Alkaloids and saponins were identified in both media; meanwhile, coumarins were only identified in CDB. The NA was only found in CDB, but not in SPDB. Coumarins could be responsible for the NA.

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Section: Discussionmentioning

confidence: 99%

Arthrobotrys musiformis (Orbiliales) Kills Haemonchus contortus Infective Larvae (Trichostronylidae) through Its Predatory Activity and Its Fungal Culture Filtrates

et al. 2022

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“…Extracts of plants and their isolated compounds which is used as inhibitors of enzymes involved in neurodegenerative disease. Coumarin glycyrol, isolated from Glycyrrhiza uralensis, used to inhibit the butyrylcholinesterase (BuChE), acetylcholinesterase (AChE) and MAO-B in micro-molar range [22].…”

Section: Review Literature Of Anti-alzheimer Potential Of Coumarin De...mentioning

confidence: 99%

Anti-Alzheimer potential of coumarin derivatives: A review

Vishesh Verma,

Nitin Kumar,

Sumit Kumar

2023

World J. Adv. Res. Rev.

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Alzheimer’s is a type of neurodegenerative diseases (NDs) found in old age people which main causes the dementia and various brain disorders. FDA approved drugs used commonly in treatment of moderate to severe Alzheimer's disease are Donepezil, Rivastigmine, Galantamine and Memantine. However, these approved drugs provide only palliative support not complete cure. So, urgency of new molecules has been becoming so important to cure this complex Disease. Coumarin or 2-H-Chromen-2-one is an oxygenated heterocyclic compound, which is isolated from plants named Dipteryx odorata Willd, (Fabaceae). Synthetic coumarin derivatives has been well presence in literature due to existence of their potential pharmacological activities in literature. This review covers the anti-Alzheimer activities of chemically synthesized coumarin derivatives from 2016-2023. Coumarin derivatives profound found exhibits potential anti-Alzheimer activities in literature. Coumarin derivatives showed their anti-Alzheimer potential through various pharmacological pathways such as monoamine oxidase (MAO) inhibitor, acetylcholinesterase (AChE) & Butyl cholinesterase (BuChE) inhibitory activity, Aβ amyloid inhibition, Beta secretase 1 (BACE1 inhibitors). Multi-target directed ligands (MTDLs) approach also extensively reported to design and synthesis of novel coumarin scaffold as potential multifunctional Anti-Alzheimer activities in last one decade. We also covered literature of some coumarin hybrids derivatives as potential Anti-Alzheimer activities. Some common synthetic methods of coumarin structure also covered in this review article. This review supported that coumarin derivatives found excellent anti-Alzheimer activities and it can be play major role to solve the problem of complex AD disease.

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“…Recently, about 150 species of coumarin have been found in 36 diverse plant families [8]. It has diverse, pharmacological activities [9][10][11][12][13][14][15] like anticancer. To target cancer, coumarin derivatives directly or indirectly inhibit the process of tubulin polymerization, mitosis, and DNA replication by inhibiting various enzymes like protein kinases, sulphatases, aromatase, caspases, and heat shock proteins [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and cytotoxic activity of some novel N-(substituted) benzamide derivatives bearing coumarin and 1-azocoumarin compounds

Al‐Hazmi¹

2023

Bull. Chem. Soc. Eth.

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ABSTRACT. Among oxygen-containing heterocyclic compounds such as coumarin and azacoumarin derivatives, the scaffold has become an important construction motif for developing new drugs. Coumarin and its derivatives possess many types of biological activities and have been reported to show significant cytotoxic activity. N-(6,8-disubstituted coumarin-3-yl)benzamides (8a-c) namely (3-N-(benzoyl) aminocoumarin-6-ylmethyl acetate (8a); N-[6-(1-acetylpyrazol-3-yldiazineyl) coumarin-3-yl] benzamide (8b); N-(8-methoxy-6-bromo-coumarin-3-yl) benzamide (8c), were synthesized via a cyclocondensation reaction of 5-(chloromethyl)-2-hydroxybenzaldehyde (3), 5-(pyrazol-3-yl-diazineyl)-2-hydroxybenzaldehyde (4), and 5-bromo-3-methoxy- 2-hydroxybenzaldehyde (5) with N-benzoylglycine (7), in good yield. Treatment of compound 8c with ammonia in the presence of anhydrous potassium carbonate to yield N-(5-bromo-8-methoxy-1-azocoumarin-3-yl) benzamide (9). Compound (9) was acetylated with acetic anhydride to give N-(2-acetoxy-5-bromo-8-methoxyquinolin-3-yl) benzamide (10). N-(substituted coumarin and azacoumarin-3-yl) benzamides (8-10) were tested for their in vitro cytotoxic activity against (HepG2) cell line. Furthermore, DNA flow cytometry investigation over HepG2 cells indicated that compound 8a demonstrated arrest at G1/S stages of the cell cycle and induction of apoptosis by rising pre-G1 stage. Compound 8a displayed a significant tubulin polymerization inhibition. KEY WORDS: Synthesis, Coumarin, Azacoumarin, Drugs, Cytotoxicity Bull. Chem. Soc. Ethiop. 2023, 37(4), 1003-1019. DOI: https://dx.doi.org/10.4314/bcse.v37i4.16

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Coumarin and Its Derivatives—Editorial

Abstract: Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules [...]

Cited by 12 publications

References 26 publications

Arthrobotrys musiformis (Orbiliales) Kills Haemonchus contortus Infective Larvae (Trichostronylidae) through Its Predatory Activity and Its Fungal Culture Filtrates

Arthrobotrys musiformis (Orbiliales) Kills Haemonchus contortus Infective Larvae (Trichostronylidae) through Its Predatory Activity and Its Fungal Culture Filtrates

Anti-Alzheimer potential of coumarin derivatives: A review

Design, synthesis, and cytotoxic activity of some novel N-(substituted) benzamide derivatives bearing coumarin and 1-azocoumarin compounds

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