Coumarinoids from the fruits of Micromelum falcatum

Suthiwong, Jittra; Sriphana, Uraiwan; Thongsri, Yordhathai; Promsuwan, Pawantree; Prariyachatigul, Chularut; Yenjai, Chavi

doi:10.1016/j.fitote.2014.02.004

Cited by 25 publications

(30 citation statements)

References 32 publications

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“…Additional study carried out by these authors also found that the alkaloid clauraila E, obtained from Clauseana harmandiana roots, another traditional medicinal plant in Thailand, was able to inhibit mycelia growth [ 24 ]. More recently, Suthiwong et al [ 25 ] found four new compounds from the fruits of Micromelum falcatum able to inhibit the mycelia growth of P. insidiosum . Fonseca et al [ 26 ] evaluated the effect of essential oils of Lamiaceae Family and observed that Origanum vulgare showed the best performance in inhibiting the germination of zoospores of P. insidiosum .…”

Section: Discussionmentioning

confidence: 99%

Stryphnodendron adstringens and purified tannin on Pythium insidiosum: in vitro and in vivo studies

Trolezi

Azanha

Paschoal

et al. 2017

Ann Clin Microbiol Antimicrob

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Background Pythium insidiosum is the etiological agent of pythiosis, an emerging life-threatening infectious disease in tropical and subtropical regions. The pathogen is a fungus-like organism resistant to antifungal therapy, for this reason, most cases need extensive surgical debridments as treatment, but depending on the size and anatomical region of the lesion, such approach is unfeasible. We investigate the fungicidal effect and toxicity of crude bark extract of Stryphnodendron adstringens and commercially available tannin on Pythium insidiosum both in vitro and in vivo.MethodsStandardized fragments of mycelia of fifteen isolates of P. insidiosum were tested with different concentrations of bark extract (10 to 30% v/v) and tannin (0.5, 1.0 and 1.5 mg/mL). For in vivo study, fifteen rabbits were experimentally infected with zoospores of P. insidiosum and treated by oral and intralesional applications of bark extract and tannin. Acute toxicity tests with both substances were also performed in rats.ResultsIn vitro studies showed fungicidal effect for both substances at different concentrations and the SEM showed alteration on the cell wall surface of the pathogen. All infected rabbits developed a firm nodular mass that reached around 90 mm2 ninety days after inoculation, but neither the intralesional inoculation of tannin, nor the oral administration of crude extract and tannin were able to promote remission of the lesions.ConclusionsLesions developed by rabbits presented an encapsulated abscess being quite different of naturally acquired pythiosis, which is characterized by ulcerated lesions. Since no toxicity was observed in rats or rabbits inoculated with these products, while in vitro experiments showed direct antifungal effect, therapeutic activity of S. adstringens and tannin should be clinically tested as an alternative for healing wounds in naturally acquired pythiosis.

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Section: Discussionmentioning

confidence: 99%

Stryphnodendron adstringens and purified tannin on Pythium insidiosum: in vitro and in vivo studies

Trolezi

Azanha

Paschoal

et al. 2017

Ann Clin Microbiol Antimicrob

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“…Prior studies demonstrated the susceptibility of P. insidiosum to antifungal agents [4,9,10,30], antibiotics [20,21,23] 1 and compounds derived from plants and fungi [16,[34][35][36] in vitro. However, tests of drug combinations were performed mainly with antifungal agents, which showed synergistic interactions of 11.8% to 46.7%, particularly when TRB was combined with other antifungal drugs [3,4,9,10].…”

Section: Discussionmentioning

confidence: 99%

In vitro activity of carvacrol and thymol combined with antifungals or antibacterials against Pythium insidiosum

Jesus

Ferreiro

Bizzi

et al. 2015

Journal de Mycologie Médicale

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“…The individual EtOAc extracts of the roots and fruit of M. integerrimum were separated by various chromatographic techniques to obtain a new compound (1) together with 23 known compounds (2-24), 6-(3-methyl-2-oxobutyroyl)-7-methoxycoumarin (2) (Li et al 2016), phebalosin (3) (Ito et al 1987), murralongin (4) (Talapatra et al 1973), osthenon (5) (Ito et al 1987), microminutin (6) (Suthiwong et al 2014), minutuminolate (7) (Lekphrom et al 2016), murrangatin acetate (8) (Ito et al 1987), (-)-murrangatin (9) (Ito et al 1990), 2′-Oethylmurrangatin (10) (Choudhary et al 2002), minumicrolin (11) (Ito et al 1990), hopeyhopin (12) (Dominguez et al 1977), dehydrogeijerin (13) (Dominguez et al 1977), isoscopoletin (14) (Shafizadeh et al 1970), scopoletin (15) (Cassady et al 1979), citropten (16) (Gray et al 1978), micromelin (17) (Cassady et al 1979), dihydromicromelin B (18) (Das et al 1994), acetyldihydromicromelin A (19) (Das et al 1994), flindulatin (20) (Collins et al 2004), gossypetin 3,7,8,4′-tetramethylether (21) (Wollenber et al 2008), 5,7-dihydroxy-3,4′,6,8-tetramethoxyflavone (22) (Silva et al 2005), 5,7-dihydroxy-3,8,4′-trimethoxyflavone (23) (Tandon et al 1977) and acerosin (24) (Greenham et al 2001).…”

Section: Resultsmentioning

confidence: 99%

Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum

Suthiphasilp

Maneerat

Andersen

et al. 2018

Natural Product Research

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A phytochemical investigation of the fruit and root extracts of Micromelum integerrimum resulted in the isolation and identification of a new compound, integerravone (1), together with 23 known compounds (2-24). Their structures were characterized by spectroscopic methods as well as comparisons made from the literature. Compounds 2, 3-15, 17-18 and 20-23 were evaluated for their cytotoxicities against the colon cancer cell line, HCT116. All of them were inactive at 50 µM. Most of the phenolic compounds were evaluated for their antioxidant activity using the DPPH assay. Compounds 14 and 22-24 showed antioxidant activity with IC50 values ranging from 24.83-135.05 µM.

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Coumarinoids from the fruits of Micromelum falcatum

Cited by 25 publications

References 32 publications

Stryphnodendron adstringens and purified tannin on Pythium insidiosum: in vitro and in vivo studies

Stryphnodendron adstringens and purified tannin on Pythium insidiosum: in vitro and in vivo studies

In vitro activity of carvacrol and thymol combined with antifungals or antibacterials against Pythium insidiosum

Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum

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