Coumarins and furocoumarins from the fruit of Prangos uloptera

Abyshev, A. Z.; Denisenko, P. P.

doi:10.1007/bf00565357

Cited by 4 publications

(3 citation statements)

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“…Osthole has been isolated from Prangos spp. (Abyshev & Denisenko, 1970;Kuznetsova et al, 1979b;Sajjadi et al, 2009) and has exerted many pharmacological effects like blood triglyceride and cholesterol lowering effects via suppression of HMG-CoA reductase gene expression (Ogawa et al, 2007), antispasmodic (Sadraei et al, 2012(Sadraei et al, , 2013, and anti-osteoporosis (Li et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Antiviral and cytotoxic evaluation of coumarins fromPrangos ferulacea

Shokoohinia

Sajjadi

Gholamzadeh

et al. 2014

Pharmaceutical Biology

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Context: Prangos ferulacea (L.) Lindl. (Apiaceae) is a perennial plant found in the Middle-East, where it is commonly used as an antispasmodic and anti-inflammatory agent. It is a rich source of coumarins. Objective: To purify several coumarins from P. ferulacea and to screen their cytotoxicity and antiherpes activity. Materials and methods: Acetone extract of roots of P. ferulacea was subjected to several chromatographic separations to render pure coumarins (1-8). Anti-herpes virus effects of 1-7 were evaluated at concentration 2.5, 5, and 10 mgmL À1 , on a confluent monolayer of Vero cells infected with 25 PFU of HSV1. Cytotoxic effects of 1 and 2 were evaluated on an A2780S cell line using the MTT assay. The cells were exposed to a series of concentrations of coumarins (0.01-2.5 mM, 37 C, 72 h). Results: Compounds 1-8 were identified as osthole, isoimperatorin, oxypeucedanin, psoralen, oxypeucedanin hydrate, gosferol, oxypeucedanin methnolate, and pranferol. This is the first report of occurrence of 4 and 7 in this plant. Compound 1 showed a viability of 9.41% ± 2.4 at 2.5 mM on A2780S cells (IC 50 ¼ 0.38 mM). The cell survival of 2 at 2.5 mM was 46.86% ± 5.5 with IC 50 equal to 1.1 mM. Discussion and conclusion: Compound 1 shows cytotoxic effects on the A2780S cell line. Compound 2 is a cyclooxygenase-2 inhibitor and the A2780S cell line does not express COX-2 which may interpret the non-toxic effect of the compound on this cell line. None of the tested compounds showed an anti-HSV effect at non-toxic concentrations.

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Section: Discussionmentioning

confidence: 99%

Antiviral and cytotoxic evaluation of coumarins fromPrangos ferulacea

Shokoohinia

Sajjadi

Gholamzadeh

et al. 2014

Pharmaceutical Biology

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“…Phytochemical studies on roots and fruits of P. uloptera revealed the presence of coumarin content (12)(13)(14). The oils obtained by steam distillation of the aerial parts and hydrodistillation of seed of P. uloptera were investigated.…”

Section: Previous Workmentioning

confidence: 99%

Essential Oil ofPrangos ulopteraDC. from Iran

Mazloomifar

Bigdeli

Saber-Tehrani

et al. 2004

Journal of Essential Oil Research

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“…However, the number of wild plants has been declining rapidly due to the changing environmental conditions over the past decades and excessive harvesting of the wild plants from native fields by horticultural trades, herbalists and husbandries. Chemical investigation of some Prangos species have shown the presence of coumarins and its derivatives [20][21][22][23][24][25][26][27] .…”

Section: Introductionmentioning

confidence: 99%