Coumarins from Stellera chamaejasmae

Abstract

Stellera chamaejasmae L., family Thymelaeaceae, is a herbaceous p~rennial found in the USSR in Eastern Siberia [1]. Its chemical composition has not been studied previously [2]. W~ hw investigatPd the composition of the coumarins of the roots of S__ chamaejasmae L. growing in the Mongolian People' s Republic. The material was collected by the resources team of a combined Soviet-Mongolian comprehensive biologicial expeditionof the Academy of Sciences of the USSR in the gorge of the river Ts~ts~rl~g in the Khangai range (Arkhangaiskii aimak, Ts~ts6rl~g somon) in June, 1972 in the flowering period of the plants. Five coumarin derivatives were detected by the chromatography (FN-12 paper with petroleum ether as the mobile phase and ethylene glycol as the stationary phase) of an ethanolic extract of the roots of S. chamaejasmae

Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme

“…Its dried roots, named “Rui-Xiang-Lang-Du” in traditional Chinese medicine, have long been used for the treatment of stubborn skin ulcers, tinea, scabies, tuberculosis, and chronic tracheitis . Previous chemical investigations on the roots of this plant have led to the isolation of diverse secondary metabolites, including highly functionalized daphnane diterpenoids, − tigliane diterpenoids, lignans, , biflavonoids, − coumarins, , and sesquiterpenoids. , In particular, certain daphnane and tigliane diterpenoids have shown extremely potent anti-HIV activity at low nanomolar concentrations with relatively low cytotoxicity. , However, these compounds are very difficult to synthesize because of their complex structure. Accordingly, further analysis of the plant material was conducted to acquire a significant quantity of several known, as well as new, anti-HIV diterpenoids from S. chamaejasme .…”

Characterization of constituents in Stellera chamaejasme L. by rapid‐resolution liquid chromatography–diode array detection and electrospray ionization time‐of‐flight mass spectrometry

“…Stellera chamaejasme L. belongs to the family of Thymelaeaceae, while Euphorbia ebracteolata Hayata and Euphorbia fischeriana Steud are from Euphorbiae, and therefore the chemical constituents in Stellera chamaejasme L. are different from those in the other two herbals. It is reported in the literature that Stellera chamaejasme L. contains such compounds as phenylpropanoid glycosides (Jin et al, 1999b), coumarins (Tukomirova et al, 1974;Modonova et al, 1985;Narantuya et al, 1994;Liu et al, 1996), lignanoids (Tatermastsu et al, 1984;Ikegawa and Ikegawa, 1996), biflavones (Liu et al, 1984;Niwa et al, 1984aNiwa et al, -c, 1986Jin et al, 1999a;Jiang et al, 2002), and diterpenes (Niwa, 1982;Feng, 1991 and1992;Ikekawa and Ikegawa, 1997). The structures of these compounds are shown in Table 1.…”