Coumarins Isolated from Angelica gigas Inhibit Acetylcholinesterase:  Structure−Activity Relationships

Kang, So Young; Lee, Ki Yong; Sung, Sang Hyun; Park, Mi Jung; Kim, Young Choong

doi:10.1021/np000441w

Cited by 214 publications

(141 citation statements)

References 20 publications

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“…12) Likewise, Kang et al found that coumarin derivatives (for example methoxsalen, isoimperatorin, and decursinol) from Angelica gigas inhibited AchE activity as well. 13) As far as we know, the present study is the first in vivo trial to study the relationship between methoxsalen and its ability to ameliorate memory impairment by modulating AchE activity.…”

Section: Discussionmentioning

confidence: 88%

Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Kim¹,

Choi²,

Bae³

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 88%

Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Kim¹,

Choi²,

Bae³

et al. 2011

Bioscience, Biotechnology, and Biochemistry

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“…Recently, several coumarin derivatives, including decursins, decursinol, decursinol angelate, nodakenin, nodakenetin, and umbelliferone, were isolated from Angelica gigas [7,19,24]. Additional pharmacological effects of these derivatives include anti-tumor activities [2,17,22], antiplatelet aggregation [25], Helicobacter pylori-suppression [3], neuroprotection [20], and memory enhancement [21,43].…”

mentioning

confidence: 99%

Anti-Inflammatory Effects of an Ethanol Extract of Angelica gigas in a Carrageenan-Air Pouch Inflammation Model

Shin¹,

Jeon²,

Park³

et al. 2009

Exp. Anim.

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Anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG; 50, 160, or 500 mg/kg) were investigated in a carrageenan-induced air pouch inflammation model. Injection of 1 ml of carrageenan (1%) into mouse air pouches markedly increased the exudate volume and exudate albumin concentration, which were significantly attenuated by oral pretreatment with EAG. EAG also markedly reduced carrageenan-induced infiltrations of neutrophils, monocytes, and lymphocytes, but did not influence eosinophils or basophils. Carrageenan dramatically increased levels of tumor necrosis factor-a and interleukin-6, which might be derived from the infiltrated cells. It also elevated nitric oxide, and slightly increased prostaglandin E 2 . EAG pretreatment significantly lowered tumor necrosis factor-a and nitric oxide, but did not alter interleukin-6 or prostaglandin E 2 levels. These results indicate that EAG attenuates some inflammatory responses by blocking the tumor necrosis factor-a-nitric oxide pathway, and that EAG could be a promising anti-inflammatory drug candidate for inflammatory diseases.

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“…The effects of skin moisturizing are easily detectable by water content through animal skin or human pilot study 18,19) . 36) . Rehmanniae Radix contained Catalpol, Verbascose and Mannitol, and Catalpol was reported as having an anti-oxidation effect 37) .…”

Section: Groupsmentioning

confidence: 99%

In Vitro Cytotoxicity, Skin Regeneration, Anti-wrinkle, Whitening and In Vivo Skin Moisturizing Effects of Oncheongeum

An¹,

Kim²

2016

The Journal of Oriental Obstetrics and Gynecology

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Objectives: The objective of this study was to evaluate the effects of cytotoxicity, skin regeneration, anti-wrinkle, whitening and skin moisturizing of Oncheongeum (OCE).Methods: The cytotoxicity of OCE lyophilized aqueous extracts (yield=13.82%) was observed against human normal fibroblast cells and B16/F10 murine melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium Bromide (MTT) assay, and skin regeneration and anti-wrinkle effects were also evaluated through the assay of collagen type I synthesis compared to the transformation of the growth factor (TGF)-β1, hyaluronidase, collagenase and matrix metalloproteinase (MMP)-1 inhibitory assays compared to oleanolic acid (OA), and elastase inhibitory effects compared to phosphoramidon disodium salt (PP). In addition, OCE's whitening effects were measured by a tyrosinase inhibitory assay and melanin formation test in B16/F10 murine melanoma cells compared to arbutin, and skin moisturizing effects were observed through a mouse skin water content test, respectively.Results: No OCE treatment-related cytotoxic effects appeared on human normal fibroblasts and B16/F10 murine melanoma cells. OCE concentration-dependently increased the collagen Type I synthesis on human normal fibroblast cells, and also effectively inhibited hyaluronidase, elastase, collagenase and MMP-1 activities. In addition, OCE inhibited melanin production of B16/F10 murine melanoma cells and activity of tyrosinase. And significant and dose-dependent increases of skin water content were detected in OCE-treated mouse skin compared to vehicle control skins.Conclusions: OCE showed favorable and sufficient effects in skin regeneration, anti-wrinkle, whitening and skin moisturizing in this experiment. But more detail mechanisms and studies on the skin protective efficiency of in vivo are needed with the screening of active biological compounds in individual OCE herbs.

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Coumarins Isolated from Angelica gigas Inhibit Acetylcholinesterase: Structure−Activity Relationships

Cited by 214 publications

References 20 publications

Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Anti-Inflammatory Effects of an Ethanol Extract of Angelica gigas in a Carrageenan-Air Pouch Inflammation Model

In Vitro Cytotoxicity, Skin Regeneration, Anti-wrinkle, Whitening and In Vivo Skin Moisturizing Effects of Oncheongeum

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