Effects of Methoxsalen from<i>Poncirus trifoliata</i>on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Kim, Jae Kyeom; Choi, Soo Jung; Bae, Hyeri; Kim, Cho Rong; Cho, Hong Yon; Kim, Young Jun; Lim, Seung Taik; Kim, Sang Hoon; Kim, Hye Kyung; Peterson, Steven W.; Shin, Dong Hoon

doi:10.1271/bbb.110386

Cited by 25 publications

(18 citation statements)

References 30 publications

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“…MDA levels were significantly (p<0.05) higher in TMT-treated animals in this study, in agreement with a previous study (25). There was an increase (9.73 nmol/mg protein, 123%) in the MDA level after TMT injection in mice, compared with control group mice (7.90 nmole/mg protein, 100%) (Fig.…”

Section: Resultssupporting

confidence: 92%

Effect of anthocyanins from rabbit-eye blueberry (Vaccinium virgatum) on cognitive function in mice under trimethyltin-induced neurotoxicity

Jin

Jeong

et al. 2015

Food Sci Biotechnol

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Extracts of rabbit-eye blueberries (Vaccinium virgatum) were investigated for in vitro neuroprotective and in vivo learning and memory effects in mice under trimethyltin (TMT)-induced neurotoxicity. Blueberry anthocyanins showed high in vitro antioxidant activities in ABTS and 2',7'-dichlorofluorescein diacetate (DCF-DA) assays. In a cell viability assay using MTT, anthocyanins showed protective effects, and lactate dehydrogenase release into the medium was effectively inhibited. Druginduced cognitive deficits, examined in vivo using Y-maze and passive avoidance testing, were ameliorated by the anthocyanin fraction. HPLC analysis showed that delphinidin was the predominant anthocyanin. After behavioral testing, acetylcholinesterase (AChE) activities and lipid peroxidation in the mouse brain were investigated for biochemical changes. Administration of blueberry anthocyanins reduced the level of TMT-induced memory injury via inhibition of the AChE activity and lipid peroxidation.

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Section: Resultssupporting

confidence: 92%

Effect of anthocyanins from rabbit-eye blueberry (Vaccinium virgatum) on cognitive function in mice under trimethyltin-induced neurotoxicity

Jin

Jeong

et al. 2015

Food Sci Biotechnol

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“…Studies have demonstrated that TMT exposure enhanced AChE staining in the hippocampal dentate gyrus, 23) and administration of TMT in mice resulted in a significant increase in AChE activity 24,25) ; such effects were observed in our study as well. We demonstrated that BP regulated the TMT-induced AChE overactivity in brain tissues.…”

Section: Discussionsupporting

confidence: 87%

2,4-Bis(1,1-dimethylethyl)phenol from <i>Cinnamomum loureirii</i> Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

Kim

Choi

Kim

et al. 2017

Biological & Pharmaceutical Bulletin

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We previously reported that the extract of Cinnamomum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present study, therefore was undertaken to demonstrate the effects of BP from C. loureirii on learning and memory impairment in trimethyltin (TMT)-treated ICR mice. Y-maze and passive avoidance tests were used to test cognitive ability. Further, changes in biochemical parameters in the brain tissue were also assessed in response to TMT injection and BP intervention. BP pre-administration (20, 40 mg/kg/d) in mice significantly protected cognitive dysfunction induced by TMT (p<0.05). Moreover, BP reduced AChE activity and lipid peroxidation but increased acetylcholine levels in the brain. In conclusion, we suggested that BP protected against TMT-induced cognitive dysfunction, and might be a potential agent for alleviating symptoms of neurodegenerative disorders, such as Alzheimer's disease, via modulating cholinergic functions.

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“…In addition, several minor phenolic acids were detected in dehulled beans such as p-hydroxybenzoic acid, vanillin, and sinapic acid, and in seed coats such as 2,3,4-trihydroxybenzoic acid. 30 The results of HPLC analysis were partially consistent with the previous report that nonanthocyanins from black soybean seed coat included protocatechuic acid, catechins, and syringic acid as main phenolics.…”

Section: Figsupporting

confidence: 90%

“…Several studies have found lipid peroxidation changes in brain tissue, including elevated MDA. 29,30 These oxidative modifications of lipids are not only detrimental themselves, but their end products (e.g., acroline, 4-hydroxynoneanal and MDA) are also reactive. 20 Hence, one should not dismiss the possibility that the nonanthocyanins attenuated the toxicity of TMT through its action as an antioxidant in the brain tissue.…”

Section: Figmentioning

confidence: 99%

Black Soybean Extract Protects Against TMT-Induced Cognitive Defects in Mice

Jeong

Kim

et al. 2014

Journal of Medicinal Food

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To find a neuroactive compound with a potent inhibitory effect on acetylcholinesterase (AChE) and in vivo anti-amnesic activity from natural resources, we evaluated anthocyanins and nonanthocyanins from black soybean extract. Nonanthocyanins from black soybean extract were the most potent and dose-dependent AChE inhibitors. Intracellular reactive oxygen species accumulation resulting from H2O2 treatment was significantly decreased compared with cells treated with H2O2 only. Nonanthocyanins were also neuroprotective against H2O2 treated neurotoxicity by 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assay. Finally, nonanthocyanins from black soybean in the preadministration group attenuated trimethyltin (TMT)-induced memory injury in both in vivo tests. AChE, prepared from mice brain tissues, was inhibited by nonanthocyanins from black soybean in a dose-dependent manner. Malondialdehyde generation in the brain homogenates of mice treated with nonanthocyanins from black soybean was decreased. We concluded that nonanthocyanins from black soybean had an efficacious in vitro AChE inhibitory activity, and protected against H2O2-induced neurotoxicity. In addition, our findings suggest that nonanthocyanins from black soybean may improve the TMT-induced learning and memory deficit because of AChE inhibition of mice brain tissue. Consequently, these results demonstrate that the nonanthocyanins from black soybean could possess a wide range of beneficial activities for neurodegenerative disorders.KEY WORDS: acetylcholinesterase black soybean cognitive function Glycine max (L.) Merr. syringic acid trimethyltin INTRODUCION Soybean (Glycine max) has been one of the long important nutritional sources since ancient times. Soybeans are extremely versatile and can be made into a variety of foods. Asians including Koreans consume an average of 20 to 80 g of traditional soy foods daily, the most common of which include tofu, miso, and tempeh. Americans consume much less soy, only about 1 to 3 g daily, and this is mostly in processed forms such as soy drinks, breakfast cereals, energy bars, and soy burgers.

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Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

Cited by 25 publications

References 30 publications

Effect of anthocyanins from rabbit-eye blueberry (Vaccinium virgatum) on cognitive function in mice under trimethyltin-induced neurotoxicity

Effect of anthocyanins from rabbit-eye blueberry (Vaccinium virgatum) on cognitive function in mice under trimethyltin-induced neurotoxicity

2,4-Bis(1,1-dimethylethyl)phenol from <i>Cinnamomum loureirii</i> Improves Cognitive Deficit, Cholinergic Dysfunction, and Oxidative Damage in TMT-Treated Mice

Black Soybean Extract Protects Against TMT-Induced Cognitive Defects in Mice

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