Coumestrol inhibits carotid sinus baroreceptor activity by cAMP/PKA dependent nitric oxide release in anesthetized male rats

Liu, Haitao; Wang, Lixuan; Ma, Huijuan; Guo, Rong; Kang, Ran; Han, Jihong; Dong, Zhao

doi:10.1016/j.bcp.2014.11.001

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…Further research is needed to better dissect the molecular mechanisms implicated in MP signaling. For instance, some flavonoids and isoflavonoids have been shown to regulate cAMP signaling in VSMCs [132,133]. Given the important and broad range of cAMP effects in human microvascular smooth muscle cells [32,34,86,134], if MP appears to modulate this pathway in these cells lines, one would expect to find diverse effects of MP on arteriolar physiology and pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

7-O-Methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells

et al. 2019

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Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from a contractile to a synthetic phenotype. The latter is characterized by increased proliferation, migration, and invasion. Compounds with anti-inflammatory actions have been successful in attenuating this phenotypic switch. While the vast majority of studies investigating phenotypic modulation were undertaken in VSMCs isolated from large vessels, little is known about the effect of such compounds on phenotypic switch in VSMCs of microvessels (microVSMCs). We have recently characterized a novel homoisoflavonoid that we called 7-O-methylpunctatin (MP). In this study, we show that MP decreased FBS-induced cell proliferation, migration, invasion, and adhesion. MP also attenuated adhesion of THP-1 monocytes to microVSMCs, abolished FBS-induced expression of MMP-2, MMP-9, and NF-κB, as well as reduced activation of ERK1/2 and FAK. Furthermore, MP-treated VSMCs showed an increase in early (myocardin, SM-22α, SM-α) and mid-term (calponin and caldesmon) differentiation markers and a decrease in osteopontin, a protein highly expressed in synthetic VSMCs. MP also reduced transcription of cyclin D1, CDK4 but increased protein levels of p21 and p27. Taken together, these results corroborate an anti-inflammatory action of MP on human microVSMCs. Therefore, by inhibiting the synthetic phenotype of microVSMCs, MP may be a promising modulator for inflammation-induced arteriolar pathophysiology.

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Section: Discussionmentioning

confidence: 99%

7-O-Methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells

et al. 2019

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Endothelial Protective Effects of Dietary Phytochemicals: Focus on Polyphenols and Carotenoids

Yamagata

2018

Studies in Natural Products Chemistry

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Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases

Yang

et al. 2021

Pharmacological Research

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Coumestrol inhibits carotid sinus baroreceptor activity by cAMP/PKA dependent nitric oxide release in anesthetized male rats

Cited by 4 publications

References 31 publications

7-O-Methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells

7-O-Methylpunctatin, a Novel Homoisoflavonoid, Inhibits Phenotypic Switch of Human Arteriolar Smooth Muscle Cells

Endothelial Protective Effects of Dietary Phytochemicals: Focus on Polyphenols and Carotenoids

Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases

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