Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases

Tu, Yanbei; Yang, Ying; Li, Yanfang; He, Chengwei

doi:10.1016/j.phrs.2021.105615

Cited by 35 publications

(14 citation statements)

References 265 publications

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“…3 , Table 2 ) (Jiang et al 2019 ). Psoralidin is a naturally occurring prenylated coumestrol extensively studied for its anti-cancer, anti-osteoporosis, anti-microbial and neuroprotective activites (reviewed in Tu et al 2021 ). However, very few papers reported the alpha-glucosidase inhibitory activity of this molecule (Oh et al 2010 ; Wang et al 2013 ; Jiang et al 2019 ).…”

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

“…Prenylated coumestans are considered as potent α-glucosidase inhibitors with the prenylated types and prenylated positions having a strong effect on this activity. Prenylation at C-2 in the case of psoralidin offers the highest inhibitory activity (Tu et al 2021 ) making this molecule a promising drug candidate.…”

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

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A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

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Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09773-1.

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Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

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“…CM possesses many biological activities, such as anticancer, antiinflammation, antiosteoporosis, lung protection, cardiovascular protection, neuroprotection, antiobesity, anti-SLE, anti-autoimmune thyroiditis, antioxidation, skin protection, and biological activity of estrogenic. 35 CM's potential health effects are reported to include estrogen and nonestrogen effects. 36 In food replacement therapy, foods containing CM may reverse fatty liver degeneration, but the mechanism is unclear.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy

Shan

Zhang

et al. 2022

Natural Product Communications

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Purpose There is limited treatment for lung squamous cell carcinoma (LUSC), so there is an urgent need to find new antitumor drugs. Materials and Methods We downloaded datasets from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas databases. We used GEO2R and the “limma” package to screen differentially expressed genes. We used the Cytoscape software to screen out hub genes. We screened herbs that act on hub genes on the Chinese medicine website. We then studied the effect of coumestrol (CM) on the hub genes in the H226 cell line. Results Seven hub genes were screened, namely CCNB2, CENPF, KIF11, MELK, nucleolar and spindle-associated protein 1 (NUSAP1), PBK, and RRM2. We observed that CM had a tumor-inhibiting effect on H226 cells by inhibiting the expression of CCNB2, KIF11, and NUSAP1. Conclusion CM, screened by bioinformatics and network pharmacology, can inhibit H226 cells by downregulating CCNB2, KIF11, and NUSAP1.

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“…Phytoestrogens have been reported to have anti‐osteoporosis effects, and the effects were related to estrogen receptor alpha (Luo et al., 2015). Lignans such as enterodiol ( ED ) and enterolactone ( EL ) are one category of phytoestrogens, in addition to isoflavones such as genistein and daidzein, as well as coumarins such as coumestrol and wedelolactone (Luo et al., 2015; Tu et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Anti‐osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model

Yang,

Wu,

Zhuang

et al. 2023

Journal of Food Science

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Secoisolariciresinol diglucoside (SDG) and tracheloside (TCL) are the main lignan components of flaxseed cake and safflower seed cake, which are by‐products of oil extraction. Both SDG and TCL are metabolized into mammalian lignan enterolactone (EL) with the involvement of intestinal bacteria. In this research, we evaluated the anti‐osteoporosis effects of SDG and the in vivo metabolites EL and enterodiol (ED) prepared in our previous work, as well as the newly isolated chemical constituents from safflower seed, including TCL, the lactone ring opening product of TCL (OTCL) and two alkaloids on the alloxan‐induced zebrafish model. All the compounds showed significant anti‐osteoporosis effects at 80 µM, with p < 0.05 for EL and p < 0.001 for other compounds compared with the model. SDG and TCL showed the most significant and concentration‐dependent effects, with p < 0.001 compared with model at 20 µM. The alkaloids, N‐coumaroylserotonin glucoside and N‐feruloylserotonin glucoside, also showed anti‐osteoporosis at 20 µM with p < 0.01, whereas EL, ED, and OTCL showed no significant effects. Quantitative real‐time polymerase chain reaction revealed that SDG and TCL upregulated the expression of osteogenic genes Runx2, SP7, OPG, Col1a1a, Alp, ON, OPN, and OCN in alloxan‐treated zebrafish. The in vivo metabolite of lignans, EL, showed significant anti‐inflammatory effect (p < 0.01) at 20 µM, which might also help to combat osteoporosis and other complications caused by excessive immune response in the body. The results provided scientific data for using the oil extraction by‐products as sources of anti‐osteoporosis compounds.Practical ApplicationThis study found that lignans in flaxseed cake and safflower seed cake exhibited anti‐osteoporosis effects by upregulating the expression of osteogenic genes, making the oil extraction by‐products sources of anti‐osteoporosis compounds.

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Naturally occurring coumestans from plants, their biological activities and therapeutic effects on human diseases

Cited by 35 publications

References 265 publications

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

The Effect of Coumestrol on Hub Genes in Lung Squamous Cell Carcinoma Based on Bioinformatic Strategy

Anti‐osteoporosis effects of mammalian lignans and their precursors from flaxseed and safflower seed using zebrafish model

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