Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal–hippocampal pathways

Liu, Ming-Gang; Lu, Dan; Wang, Yan; Chen, Xuefeng; Li, Zhen; Yan, Xu; Jin, Jian-Hui; Wang, Ruirui; Chen, Jun

doi:10.1016/j.neulet.2011.11.046

Cited by 16 publications

(21 citation statements)

References 24 publications

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“…AM251, CNQX, nimodipine, chelerythrine, KT5720, KN62, Naspm, ZIP and S‐ZIP were from Tocris Cookson (Bristol, UK); AP5, MPEP, CPCCOEt, okadaic acid and DHPG were from Abcam Biochemicals (Cambridge, UK). The doses for each compound were chosen on the basis of our preliminary experiments and related in vitro studies (Wei et al ., ; Huang & Hsu, ; Li et al ., ; Izumi & Zorumski, ; Liu et al ., ; Nicolas et al ., ). For the pharmacological characterisation of LFS‐evoked LTD, AM251, AP5, nimodipine, MPEP and CPCCOEt were applied throughout the whole recording period, whereas chelerythrine, KT5720, KN62, okadaic acid, ZIP and S‐ZIP were given 25 min prior to and during LTD induction.…”

Section: Methodsmentioning

confidence: 99%

Long‐term depression of synaptic transmission in the adult mouse insular cortex in vitro

Liu

Koga

Guo

et al. 2013

Eur J of Neuroscience

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The insular cortex (IC) is known to play important roles in higher brain functions such as memory and pain. Activity-dependent long-term depression (LTD) is a major form of synaptic plasticity related to memory and chronic pain. Previous studies of LTD have mainly focused on the hippocampus, and no study in the IC has been reported. In this study, using a 64-channel recording system, we show for the first time that repetitive low-frequency stimulation (LFS) can elicit frequency-dependent LTD of glutamate receptor-mediated excitatory synaptic transmission in both superficial and deep layers of the IC of adult mice. The induction of LTD in the IC required activation of the N-methyl-d-aspartate (NMDA) receptor, metabotropic glutamate receptor (mGluR)5, and L-type voltage-gated calcium channel. Protein phosphatase 1/2A and endocannabinoid signaling are also critical for the induction of LTD. In contrast, inhibiting protein kinase C, protein kinase A, protein kinase Mζ or calcium/calmodulin-dependent protein kinase II did not affect LFS-evoked LTD in the IC. Bath application of the group I mGluR agonist (RS)-3,5-dihydroxyphenylglycine produced another form of LTD in the IC, which was NMDA receptor-independent and could not be occluded by LFS-induced LTD. Our studies have characterised the basic mechanisms of LTD in the IC at the network level, and suggest that two different forms of LTD may co-exist in the same population of IC synapses.

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Section: Methodsmentioning

confidence: 99%

Long‐term depression of synaptic transmission in the adult mouse insular cortex in vitro

Liu

Koga

Guo

et al. 2013

Eur J of Neuroscience

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“…6). This augmented LTP is dependent on the peripherally painful state and activation of mGluR5, ERK and JNK, but with negative modulation by mGluR1 and p38 MAPK in the EC-DG and EC-CA1 pathways [32,33] . Overall, using MEAs to record LTP has the following advantages: (1) it can reveal the spatial proper-ties of LTP distribution in different microcircuits or layers within a single slice; (2) it provides a much longer period of LTP recording than conventional electrophysiological techniques; and (3) it maps LTP induction within a wider scope and reveals its alteration under pathological conditions.…”

Section: Examples Of Ltp Recording Using Mea Techniquesmentioning

confidence: 98%

“…5) [31] . In addition, mGluR1 and p38 MAPK appear to be involved in the tonic inhibition of EC-DG and EC-CA1 synaptic enhancement, while ERK may mediate persistent painassociated spatial extension [32,33] . Moreover, the enhancing effects on the spatial organization of network synaptic con- physiology and in vitro patch clamp recording), and further highlight the superiority of multisite recording using MEA techniques.…”

Section: Experimental Setupsmentioning

confidence: 99%

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Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

Liu

Chen

et al. 2012

Neurosci. Bull.

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Simultaneous multisite recording using multi-electrode arrays (MEAs) in cultured and acutely-dissociated brain slices and other tissues is an emerging technique in the field of network electrophysiology. Over the past 40 years, great efforts have been made by both scientists and commercial concerns, to advance this technique. The MEA technique has been widely applied to many regions of the brain, retina, heart and smooth muscle in various studies at the network level.The present review starts from the development of MEA techniques and their uses in brain preparations, and then specifically concentrates on the use of MEA recordings in studies of synaptic plasticity at the network level in both the temporal and spatial domains. Because the MEA technique helps bridge the gap between single-cell recordings and behavioral assays, its wide application will undoubtedly shed light on the mechanisms underlying brain functions and dysfunctions at the network level that remained largely unknown due to the technical difficulties before it matured.

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“…18 The system comprised an MED64 amplifier (composed of a head amplifier and a main amplifier. Head amplifier: Gain was x10; Bandwidth was 0.1-10 Hz; Input impedance was 100 M; Output impedance was 10 k; Power supply was DCþ/À12V.…”

Section: Measuring Instrumentsmentioning

confidence: 99%

Effects of Acute Hyperglycemia and Insulin Intervention on the Spontaneous Field Potential of Sinoatrial Node Tissue by Using Microelectrode Arrays

Feng

Cao

Zhang

2015

J. Mech. Med. Biol.

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Traditional studies on the relationship between hyperglycemia and heart diseases generally focused on the impact of chronic and long-term effect of diabetes on cardiac functions. Most of the methods were culturing myocardial cells and giving outside stimulations. However, recent studies show that acute hyperglycemia might play a significant role in spontaneous cardiac electrophysiology. In this research we applied microelectrode arrays (MEA) to record the spontaneous sinoatrial node field potentials of C57/BL6J mice and analyzed the effects of different glucose concentrations in time domain and frequency domain by using statistical method, vector maps and fast Fourier transform (FFT). Meanwhile, we studied the effects of insulin interference in the experimental process. When the concentration of the glucose solution was greater than 40 mmol/L, the spontaneous sinoatrial node field potential changed markedly. In the time domain, the amplitude decreased rapidly and the conductive characteristics were disordered. In the frequency domain, the two spectrum peaks decreased rapidly. These changes were irreversible. However, insulin preconditioning could inhibit the impact of high glucose.

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Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal–hippocampal pathways

Cited by 16 publications

References 24 publications

Long‐term depression of synaptic transmission in the adult mouse insular cortex in vitro

Long‐term depression of synaptic transmission in the adult mouse insular cortex in vitro

Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

Effects of Acute Hyperglycemia and Insulin Intervention on the Spontaneous Field Potential of Sinoatrial Node Tissue by Using Microelectrode Arrays

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