Counterintuitive Antidepressant Properties of Slow rTMS Over the Left Frontal Cortex: A Possible Mechanism

Schutter, D.J.L.G.; d'Alfonso, Alfredo A.L; Honk, E.J. van

doi:10.1176/jnp.15.2.243

Cited by 4 publications

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“…The involvement of reduced information transfer between different brain regions in depression was recently put forward by Schutter et al (16). These authors argued that the antidepressant effects of clinical studies in depressive patients utilizing fast repetitive transcranial magnetic stimulation over the frontal cortex, commonly argued to be due to enhancement of neuronal activity (17,18), do more likely result from enhanced corticocortical cross-talk (16,19). This suggestion finds strong support in the recent observation of increased cross-talk between the frontal and parietal regions after repetitive transcranial magnetic stimulation over the frontal cortex in healthy volunteers (20).…”

Section: Discussionmentioning

confidence: 98%

Cortisol, depression and reduced cortico-cortical cross-talk in Cushing’s syndrome

Schutter

Honk

Haan

et al. 2004

J Endocrinol Invest

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ABSTRACT:In the present report assumed relationships between hypercortisolism, depression and cortico-cortical cross-talk in Cushing's syndrome were investigated. Electroencephalographic (EEG) recordings and depression ratings from three patients diagnosed with mild, moderate and severe hypercortisolism were obtained. Reductions in cortico-cortical cross-talk as quantified by EEG coherence and increased depression were observed in the moderate and severe as compared to the mild hypercorticolism state. These findings provide preliminary evidence for the hypothesis that loss of corticocortical cross-talk might be linked to hypercortisolism and the severity of depressive symptoms. (J. Endocrinol. Invest. 27:683-686, 2004)

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Section: Discussionmentioning

confidence: 98%

Cortisol, depression and reduced cortico-cortical cross-talk in Cushing’s syndrome

Schutter

Honk

Haan

et al. 2004

J Endocrinol Invest

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“…In line with our hypothesis, T as compared to placebo induced a significant increase in the functional connectivity in this left prefrontal-right parietal cortico-cortical depression circuit. 19 Although EEG coherence between different cortical regions is largely established by cortico-cortical and thalamo-cortical interactions, 22 subcortical brain areas contribute to both inter-and intrahemispheric functional communication as well. 23 Especially the lower bandwidths such as the r frequency in the EEG coherence spectrum have been associated with limbic contributions to cortico-cortical coupling.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 However, findings in the Rosenberg et al 18 study can be interpreted in terms of the strengthening of the functional connectivity in the left prefrontal-right parietal corticocortical depression circuit by both slow and fast rTMS. 19 Finally, working from a heuristic model constituting this depression circuit, and assuming that rTMS would also be capable of strengthening functional connectivity when stimulating the right parietal cortex, a recent placebo controlled study by Van Honk and Schutter 20 demonstrated reductions in phenomenological, attentional and physiological indices of depression in healthy volunteers after slow rTMS over the right parietal cortex.…”

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confidence: 99%

Administration of Testosterone Increases Functional Connectivity in a Cortico-Cortical Depression Circuit

Schutter¹,

Peper²,

Koppeschaar³

et al. 2005

JNP

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Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states

et al. 2019

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Background Perceived loneliness, an increasingly prevalent social issue, is closely associated with major depressive disorder (MDD). However, the neural mechanisms previously implicated in key cognitive and affective processes in loneliness and MDD still remain unclear. Such understanding is critical for delineating the psychobiological basis of the relationship between loneliness and MDD. Methods We isolated the unique and interactive cognitive and neural substrates of loneliness and MDD among 27 MDD patients (mean age = 51.85 years, 20 females), and 25 matched healthy controls (HCs; mean age = 48.72 years, 19 females). We assessed participants' behavioral performance and neural regional and network functions on a Stroop color-word task, and their resting-state neural connectivity. Results Behaviorally, we found greater incongruence-related accuracy cost in MDD patients, but reduced incongruence effect on reaction time in lonelier individuals. When performing the Stroop task, loneliness positively predicted prefrontal-anterior cingulate-parietal connectivity across all participants, whereas MDD patients showed a decrease in connectivity compared to controls. Furthermore, loneliness negatively predicted parietal and cerebellar activities in MDD patients, but positively predicted the same activities in HCs. During resting state, MDD patients showed reduced parietal-anterior cingulate connectivity, which again positively correlated with loneliness in this group. Conclusions We speculate the distinct neurocognitive profile of loneliness might indicate increase in both bottom-up attention and top-down executive control functions. However, the upregulated cognitive control processes in lonely individuals may eventually become exhausted, which may in turn predispose to MDD onset.

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Counterintuitive Antidepressant Properties of Slow rTMS Over the Left Frontal Cortex: A Possible Mechanism

Cited by 4 publications

References 0 publications

Cortisol, depression and reduced cortico-cortical cross-talk in Cushing’s syndrome

Cortisol, depression and reduced cortico-cortical cross-talk in Cushing’s syndrome

Administration of Testosterone Increases Functional Connectivity in a Cortico-Cortical Depression Circuit

Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states

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