Counterpoint: Long-Term Antibiotic Therapy Improves Persistent Symptoms Associated with Lyme Disease

Stricker, Raphael B.

doi:10.1086/518853

Cited by 100 publications

(78 citation statements)

References 137 publications

(162 reference statements)

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“…Three of these randomized trials have been criticized as offering "too little, too late" [68][69][70], based on retrospective, open-label case-series that suggested a possible role of prolonged antibiotic therapy in patients diagnosed with "chronic Lyme disease" [71,72]. In general, caseseries studies are fraught with potential for biases.…”

Section: Studies Of Antibiotic Treatment In Post-lyme Disease Syndromementioning

confidence: 99%

Chronic Lyme Disease: A Review

Marques

2008

Infectious Disease Clinics of North America

178

123

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Section: Studies Of Antibiotic Treatment In Post-lyme Disease Syndromementioning

confidence: 99%

Chronic Lyme Disease: A Review

Marques

2008

Infectious Disease Clinics of North America

178

123

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“…The progression of chronic arthritis appears to be independent of spirochetes at the disease site. However, significant controversy about this topic still exists within the field of Lyme disease (7,142).…”

Section: Arthritis Development In the Absence Of B Burgdorferimentioning

confidence: 99%

Lyme Arthritis: Current Concepts and a Change in Paradigm

Nardelli

Callister

Schell

2008

Clin Vaccine Immunol

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“…Borrelia burgdorferi are characterised by a very complicated genetic structure which enables them to effectively adapt to the human organism and to avoid immune response through the strategy of 'stealth pathology,' which covers, among other things, the immunosuppressive effect of B. burgdorferi, its development in various tissues, secretion of harmful substances, and antigenic variability (11). The taxonomy of B. burgdorferi is based on genetic criteria; hence, in the scientific literature, the term 'Borrelia burgdorferi sensu lato' is used to describe a collective species which comprises a number of genospecies, of which Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii occur most frequently in Europe and cause arthritis, skin infections and neural infections (4,12,13).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of tick-borne pathogens at various workplaces in forest exploitation environment

Cisak¹,

Wójcik-Fatla²,

Zając³

et al. 2014

Med Pr

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Background: The objective of the study was the evaluation of the infection of ticks with pathogenic microorganisms at various workplaces (timber acquisition, forest growing, forest cultivation, forest protection). Material and Methods: Eight hundred sixty one Ixodes ricinus ticks collected from 4 workplaces were examined for the presence of Borrelia burgdorferi, Anaplasma phagocytophilum and Babesia microti by polymerase chain reaction (PCR). Then, a comparative analysis of the relative density and infection of ticks at individual workplaces was done. In the statistical analysis, Chi 2 test, and Pearson's test for correlation were applied. Results: The differences in infection (15.9-50%) of ticks with B. burgdorferi between the examined workplaces were highly significant, with the highest percentage observed at forest growing. The percentages of infection of ticks with A. phagocytophilum at individual workplaces ranged from 1.1-3.7%, and differences were statistically insignificant. The percentages of infections of ticks with Babesia microti at individual workplaces fluctuated from 3.6-4.4% and differences were also insignificant. Co-infections of ticks with 2 or 3 pathogens were rare. Conclusions: Co-infections with B. burgdorferi and B. microti showed a significant relationship with the workplaces, while those with B. burgdorferi and A. phagocytophilum did not show such a dependence. No significant positive correlation was found between the relative density of ticks and the frequencies of infections with B. burgdorferi, A. phagocytophilum and B. microti. Med Pr 2014;65(5):575-581

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Counterpoint: Long-Term Antibiotic Therapy Improves Persistent Symptoms Associated with Lyme Disease

Abstract: Prolonged antibiotic therapy may be useful and justifiable in patients with persistent symptoms of Lyme disease and coinfection with tickborne agents.

Cited by 100 publications

References 137 publications

Chronic Lyme Disease: A Review

Chronic Lyme Disease: A Review

Lyme Arthritis: Current Concepts and a Change in Paradigm

Prevalence of tick-borne pathogens at various workplaces in forest exploitation environment

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