Counting particles by means of optoacoustics: Potential limits in real solutions

Autrey, Tom; Egerev, S. V.; Foster, Nancy S.; Fokin, A. V.; Ovchinnikov, Oleg B.

doi:10.1063/1.1519687

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…One method is to plot probability histograms, i.e. probability of vapor bubble generation as a function of laser fluence [1]. The second method is to plot rank distributions, i.e.…”

Section: Simulation With Monte Carlo Methodsmentioning

confidence: 99%

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Pulsed optoacoustic interaction in suspension of gold nanoparticles: detection sensitivity based on laser-induced nanobubbles

et al. 2005

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The sensitivity of optoacoustic (OA) detection in diluted suspensions of gold nanoparticles under irradiation with nanosecond laser pulses was studied as a function of incident laser fluence. The range of moderate values of the laser fluence from 20 mJ/cm 2 to 2 J/cm 2 was studied theoretically and experimentally. Under these laser fluences, the usual thermoelastic mechanism of OA generation faces competition from laser-induced cavitation, a statistical process, which leads to considerable fluctuations of the acoustic response from one laser pulse to another. Analytical expressions for the statistical characteristics of the acoustic signal were obtained. A simulation of the statistical characteristics of the cavitation contribution to the signal was performed using the method of Monte Carlo. The experiment utilized the second harmonic pulses (532 nm) of an Nd:YAG laser to irradiate samples of water suspensions of spherical gold nanoparticles (NPs). A series of laser pulses each having from 100 to 2000 pulses were used to iradiate the samples. The statistical rank distributions of the magnitudes of optoacoustic signals recorded by a wide band ultrasonic transducer attached to the measurement cell were used as a tool for sensitive detection of a low concentration of the gold nanoparticles in water.

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“…One method is to plot probability histograms, i.e. probability of vapor bubble generation as a function of laser fluence [1]. The second method is to plot rank distributions, i.e.…”

Section: Simulation With Monte Carlo Methodsmentioning

confidence: 99%

“…A striking example of the statistical nature of optoacoustic conversion is the effect of laser generation of ultrasound in aqueous suspensions of particles and other heterogeneous media [1]. This effect is the subject of the present study.…”

Section: Introductionmentioning

confidence: 97%

Pulsed optoacoustic interaction in suspension of gold nanoparticles: detection sensitivity based on laser-induced nanobubbles

et al. 2005

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“…Thus, not only can the presence and number of CTCs be determined, but isolation of the CTC will allow verification of the test, along with the opportunity to conduct studies on CTCs to investigate questions about tumor biology and to provide clinically relevant information for management of advanced cancer. Photoacoustics has been used to detect particles in suspension in a flowmetry scheme by Autrey et al [27]. They performed measurements on latex microspheres and conducted analysis and modeling of the photoacoustic response with respect to shape and number.…”

Section: Photoacoustic Interactions With Nanoparticlesmentioning

confidence: 99%

Gold Nanoparticle–Mediated Detection of Circulating Cancer Cells

Bhattacharyya

Goldschmidt

Hannink

et al. 2012

Clinics in Laboratory Medicine

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“…10 Photoacoustics has been used for particle detection and counting to exploit optical absorption of materials of interest. 11 Photoacoustic°ow cytometry, in which the medium containing cells of interest is under°ow, has been used for detection of pigmented cells in body°uids. 12,14 In particular, Zharov et al, performed in vivo detection of CTCs.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic detection of circulating melanoma cells in late stage patients

Viator

Hazur

Sajewski

et al. 2020

J. Innov. Opt. Health Sci.

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Melanoma is the deadliest skin cancer and is responsible for over 7000 deaths in the US annually. The spread of cancer, or metastasis, is responsible for these deaths, as secondary tumors interrupt normal organ function. Circulating tumor cells, or those cells that spread throughout the body from the primary tumor, are thought to be responsible for metastasis. We developed an optical method, photoacoustic flow cytometry, in order to detect and enumerate circulating melanoma cells (CMCs) from blood samples of patients. We tested the blood of Stage IV melanoma patients to show the ability of the photoacoustic flow cytometer to detect these rare cells in blood. We then tested the system on archived blood samples from Stage III melanoma patients with known outcomes to determine if detection of CMCs can predict future metastasis. We detected between 0 and 66 CMCs in Stage IV patients. For the Stage III study, we found that of those samples with CMCs, two remained disease free and five developed metastasis. Of those without CMCs, six remained disease free and one developed metastasis. We believe that photoacoustic detection of CMCs provides valuable information for the prediction of metastasis and we postulate a system for more accurate prognosis.

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Counting particles by means of optoacoustics: Potential limits in real solutions

Cited by 10 publications

References 6 publications

Pulsed optoacoustic interaction in suspension of gold nanoparticles: detection sensitivity based on laser-induced nanobubbles

Pulsed optoacoustic interaction in suspension of gold nanoparticles: detection sensitivity based on laser-induced nanobubbles

Gold Nanoparticle–Mediated Detection of Circulating Cancer Cells

Photoacoustic detection of circulating melanoma cells in late stage patients

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